A Clinical Approach Towards Smell Loss in Parkinson's Disease

2014 ◽  
Vol 4 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Antje Haehner ◽  
Thomas Hummel ◽  
Heinz Reichmann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Approach ◽  
Smell Loss

scholarly journals A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease

2020 ◽  
Author(s):  
Emahnuel Troisi Lopez ◽  
Roberta Minino ◽  
Pierpaolo Sorrentino ◽  
Rosaria Rucco ◽  
Anna Carotenuto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Relevance ◽  
Balance Control ◽  
Center Of Mass ◽  
Motor Impairment ◽  
Clinical Approach ◽  
Gait Parameters ◽  
Motor Condition ◽  
Relationship Of

AbstractBACKGROUNDParkinson’s disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-dependent observational criteria. A synthetic, replicable index to quantify motor impairment is still lacking. In this paper, we build upon the idea that the trunk is crucial in balance control. Hence, we have designed a new measure of postural stability which assesses the trunk displacement in relation to the center of mass, that we named trunk displacement index (TDI).METHODSTwenty-three PD patients and twenty-three healthy controls underwent clinical (UPDRS-III) and motor examination (3D gait analysis). The TDI was extracted from kinematic measurements using a stereophotogrammetric system. A correlation analysis was performed to assess the relationship of TDI with typical gait parameters, to verify its biomechanical value, and UPDRS-III, to observe its clinical relevance. Finally, its sensitivity was measured, comparing pre- and post-L-DOPA subclinical intake.RESULTSThe TDI showed significant correlations with many gait parameters, including both velocity and stability characteristics of gait, and with the UPDRS-III. Finally, the TDI resulted capable in discriminating between off and on state in PD, whereas typical gait parameters failed two show any difference between those two conditions.CONCLUSIONSOur results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation.

scholarly journals A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Emahnuel Troisi Lopez ◽  
Roberta Minino ◽  
Pierpaolo Sorrentino ◽  
Rosaria Rucco ◽  
Anna Carotenuto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Center Of Mass ◽  
Motor Impairment ◽  
Clinical Approach ◽  
System A ◽  
Gait Parameters ◽  
Highly Sensitive ◽  
Motor Condition ◽  
Relationship Of

AbstractParkinson's disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-dependent observational criteria. A synthetic, replicable index to quantify motor impairment is still lacking. Hence, we have designed a new measure of postural stability which assesses the trunk displacement in relation to the center of mass, that we named trunk displacement index (TDI). Twenty-three PD patients and twenty-three healthy controls underwent motor examination through a stereophotogrammetric system. A correlation analysis was performed to assess the relationship of TDI with gait parameters and clinical motor scale (UPDRS-III). The TDI sensitivity was estimated, comparing pre- and post- L-DOPA subclinical dose intake. The TDI showed significant correlations with many gait parameters and with the UPDRS-III. Furthermore, the TDI resulted capable in discriminating between off and on state in PD, whereas gait parameters failed two show any difference between those two conditions. Our results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation.

Paired neurophysiological and clinical approach to brainstem assessment in Parkinson’s Disease

2016 ◽  
Vol 127 (3) ◽  
pp. e1
Author(s):  
E.R. de Natale ◽  
F. Ginatempo ◽  
A. Manca ◽  
K.S. Paulus ◽  
V. Agnetti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Approach

scholarly journals Olfaction in Parkinson’s Disease – A Clinical Approach

2020 ◽  
Vol 15 (1) ◽  
pp. 37
Author(s):  
Antje Haehner ◽  
Thomas Hummel ◽  
Heinz Reichmann ◽  
◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Approach

Prevalence of smell loss in Parkinson's disease – A multicenter study

2009 ◽  
Vol 15 (7) ◽  
pp. 490-494 ◽  
Author(s):  
A. Haehner ◽  
S. Boesveldt ◽  
H.W. Berendse ◽  
A. Mackay-Sim ◽  
J. Fleischmann ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multicenter Study ◽  
Smell Loss
Sign in / Sign up

Export Citation Format

Share Document