scholarly journals The origin of human complex diversity: Stochastic epistatic modules and the intrinsic compatibility between distributional robustness and phenotypic changeability

2018 ◽  
Vol 17 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Shinji Ijichi ◽  
Naomi Ijichi ◽  
Yukina Ijichi ◽  
Chikako Imamura ◽  
Hisami Sameshima ◽  
...  
Keyword(s):  
Distributional Robustness ◽  
Human Complex

scholarly journals CirBiTree: Citrullination Site Inference Based on a Fuzzy Neural Network and Flexible Neural Tree

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Chuandong Song ◽  
Haifeng Wang
Keyword(s):  
Neural Network ◽  
Fuzzy Neural Network ◽  
Classification Model ◽  
Peptide Sequence ◽  
Sequence Information ◽  
Post Translational Modification ◽  
Fuzzy Neural ◽  
Human Complex ◽  
Better Than

Emerging evidence demonstrates that post-translational modification plays an important role in several human complex diseases. Nevertheless, considering the inherent high cost and time consumption of classical and typical in vitro experiments, an increasing attention has been paid to the development of efficient and available computational tools to identify the potential modification sites in the level of protein. In this work, we propose a machine learning-based model called CirBiTree for identification the potential citrullination sites. More specifically, we initially utilize the biprofile Bayesian to extract peptide sequence information. Then, a flexible neural tree and fuzzy neural network are employed as the classification model. Finally, the most available length of identified peptides has been selected in this model. To evaluate the performance of the proposed methods, some state-of-the-art methods have been employed for comparison. The experimental results demonstrate that the proposed method is better than other methods. CirBiTree can achieve 83.07% in sn%, 80.50% in sp, 0.8201 in F1, and 0.6359 in MCC, respectively.

scholarly journals Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

2021 ◽  
Author(s):  
Valentin Hivert ◽  
Julia Sidorenko ◽  
Florian Rohart ◽  
Michael E. Goddard ◽  
Jian Yang ◽  
...  
Keyword(s):  
Complex Traits ◽  
Genetic Variance ◽  
Additive Genetic Variance ◽  
Large Sample ◽  
Human Complex

scholarly journals Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

Retrovirology ◽  
2009 ◽  
Vol 6 (1) ◽  
pp. 10 ◽  
Author(s):  
Jennifer A Mertz ◽  
Mary M Lozano ◽  
Jaquelin P Dudley
Keyword(s):  
Responsive Element ◽  
Human Complex
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