Increased Serotonin Transporter Expression in Huntington’s Disease Patients Is Not Consistently Replicated in Murine Models

2019 ◽  
Vol 8 (4) ◽  
pp. 449-457
Author(s):  
Yanqing He ◽  
Yalikun Suofu ◽  
Svitlana Yablonska ◽  
Xiaoming Wang ◽  
Timothy M. Larkin ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Serotonin Transporter ◽  
Murine Models ◽  
Transporter Expression

scholarly journals Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Valentina Fodale ◽  
Roberta Pintauro ◽  
Manuel Daldin ◽  
Roberta Altobelli ◽  
Maria Carolina Spiezia ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Molecular Mechanisms ◽  
Neurodegenerative Disorder ◽  
Tissue Expression ◽  
Peripheral Tissue ◽  
Mutant Form ◽  
Murine Models ◽  
Therapeutic Approaches ◽  
And Control

AbstractHuntington’s disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form of HTT is a key aspect of diseased tissues, and the most promising therapeutic approaches aim to lower expanded HTT levels. Consequently, the investigation of HTT expression in time and in multiple tissues, with assays that accurately quantify expanded and non-expanded HTT, are required to delineate HTT homeostasis and to best design and interpret pharmacodynamic readouts for HTT lowering therapeutics. Here we evaluate mutant polyglutamine-expanded (mHTT) and polyglutamine-independent HTT specific immunoassays for validation in human HD and control fibroblasts and use to elucidate the CSF/brain and peripheral tissue expression of HTT in preclinical HD models.

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington’s disease

2007 ◽  
Vol 0 (0) ◽  
pp. 071106212705008-??? ◽  
Author(s):  
Andreas Weiss ◽  
Corinna Klein ◽  
Ben Woodman ◽  
Kirupa Sathasivam ◽  
Miriam Bibel ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Murine Models ◽  
Symptom Development

scholarly journals Glutamate transporter expression and function in a striatal neuronal model of Huntington’s disease

2013 ◽  
Vol 62 (7) ◽  
pp. 973-981 ◽  
Author(s):  
Geraldine T. Petr ◽  
Ekaterina Bakradze ◽  
Natalie M. Frederick ◽  
Jianlin Wang ◽  
Wencke Armsen ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Glutamate Transporter ◽  
Neuronal Model ◽  
And Function ◽  
Transporter Expression

scholarly journals Cell-intrinsic glial pathology is conserved across human and murine models of Huntington’s disease

Cell Reports ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 109308
Author(s):  
Abdellatif Benraiss ◽  
John N. Mariani ◽  
Mikhail Osipovitch ◽  
Adam Cornwell ◽  
Martha S. Windrem ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Murine Models
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