scholarly journals Cognitive Performance After a One-Year Multidisciplinary Intensive Rehabilitation Program for Huntington’s Disease: An Observational Study

2018 ◽  
Vol 7 (4) ◽  
pp. 379-389 ◽  
Author(s):  
Marleen R. van Walsem ◽  
Anu Piira ◽  
Geir Mikalsen ◽  
Hanne Ludt Fossmo ◽  
Emilie I. Howe ◽  
...  
Keyword(s):  
Observational Study ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Performance ◽  
Rehabilitation Program ◽  
One Year ◽  
Intensive Rehabilitation

Effect of an interval rehabilitation program with home-based, vibration-assisted training on the development of muscle and bone in children with cerebral palsy – an observational study

2020 ◽  
Vol 33 (8) ◽  
pp. 1083-1092 ◽  
Author(s):  
Ibrahim Duran ◽  
Kyriakos Martakis ◽  
Christina Stark ◽  
Leonie Schafmeyer ◽  
Mirko Rehberg ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Bone Growth ◽  
Muscle Growth ◽  
Rehabilitation Program ◽  
Whole Body ◽  
Cross Sectional ◽  
Home Based ◽  
Children With Cerebral Palsy ◽  
One Year ◽  
Intensive Rehabilitation

AbstractObjectivesIn children with cerebral palsy (CP), the most common cause of physical impairment in childhood, less muscle and bone growth has been reported, when compared with typically developing children. The aim of this study was to evaluate the effect of an intensive rehabilitation program including physiotherapy in combination with 6 months of home-based, vibration-assisted training on muscle and bone growth in children with CP.MethodsWe included children with CP, who participated in a rehabilitation program utilizing whole-body vibration (WBV). Muscle mass was quantified by appendicular lean mass index (App-LMI) and bone mass by total-body-less-head bone mineral content (TBLH-BMC) assessed by Dual-energy X-ray absorptiometry (DXA) at the beginning of rehabilitation and one year later. To assess the functional muscle-bone unit, the relation of TBLH-BMC to TBLH lean body mass (TBLH-LBM) was used.ResultsThe study population included 128 children (52 females, mean age 11.9 ± 2.7). App-LMI assessed in kg/m2 increased significantly after rehabilitation. The age-adjusted Z-score for App-LMI showed no significant change. TBLH-BMC assessed in gram increased significantly. The Z-scores for TBLH-BMC decreased lesser than expected by the evaluation of the cross-sectional data at the beginning of rehabilitation. The parameter $\frac{TBLH-BMC}{TBLH-LBM}$ did not change relevantly after 12 months.ConclusionsMuscle growth and to a lesser extent bone growth could be increased in children with CP. The intensive rehabilitation program including WBV seemed to have no direct effect on the bone, but the observed anabolic effect on the bone, may only been mediated through the muscle.

scholarly journals Reduced penetrance alleles for Huntington's disease: a multi-centre direct observational study

2006 ◽  
Vol 44 (3) ◽  
pp. e68-e68 ◽  
Author(s):  
O. W J Quarrell ◽  
A. S Rigby ◽  
L Barron ◽  
Y Crow ◽  
A Dalton ◽  
...  
Keyword(s):  
Observational Study ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Reduced Penetrance

scholarly journals Thalamic Atrophy in Huntington's Disease Co-varies with Cognitive Performance: A Morphometric MRI Analysis

2004 ◽  
Vol 15 (6) ◽  
pp. 846-853 ◽  
Author(s):  
Jan Kassubek ◽  
Freimut D. Juengling ◽  
Daniel Ecker ◽  
G. Bernhard Landwehrmeyer
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Performance
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