Improved Executive Function and Callosal White Matter Microstructure after Rhythm Exercise in Huntington's Disease

2014 ◽  
Vol 3 (3) ◽  
pp. 273-283 ◽  
Author(s):  
Claudia Metzler-Baddeley ◽  
Jaime Cantera ◽  
Elizabeth Coulthard ◽  
Anne Rosser ◽  
Derek K. Jones ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
White Matter Microstructure

E14 White Matter Microstructure In Huntington's Disease: 18 Month Data From The Image-hd Study

2014 ◽  
Vol 85 (Suppl 1) ◽  
pp. A40-A41
Author(s):  
G. Poudel ◽  
J. Stout ◽  
J. Dominguez ◽  
A. Churchyard ◽  
P. Chua ◽  
...  
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
White Matter Microstructure

Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study

2015 ◽  
Vol 74 ◽  
pp. 406-412 ◽  
Author(s):  
Govinda R. Poudel ◽  
Julie C. Stout ◽  
Juan F. Domínguez D. ◽  
Andrew Churchyard ◽  
Phyllis Chua ◽  
...  
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Longitudinal Change ◽  
White Matter Microstructure

scholarly journals Neuropsychiatry and White Matter Microstructure in Huntington’s Disease

2015 ◽  
Vol 4 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Sarah Gregory ◽  
Rachael I. Scahill ◽  
Kiran K. Seunarine ◽  
Cheryl Stopford ◽  
Hui Zhang ◽  
...  
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
White Matter Microstructure

scholarly journals Natural biological variation of white matter microstructure is accentuated in Huntington's disease

2018 ◽  
Vol 39 (9) ◽  
pp. 3516-3527 ◽  
Author(s):  
Sarah Gregory ◽  
Helen Crawford ◽  
Kiran Seunarine ◽  
Blair Leavitt ◽  
Alexandra Durr ◽  
...  
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Biological Variation ◽  
White Matter Microstructure

scholarly journals Altered white matter microstructure in the corpus callosum in Huntington's disease: Implications for cortical “disconnection”

NeuroImage ◽  
2010 ◽  
Vol 49 (4) ◽  
pp. 2995-3004 ◽  
Author(s):  
H. Diana Rosas ◽  
Stephanie Y. Lee ◽  
Alexander C. Bender ◽  
Alexandra K. Zaleta ◽  
Mark Vangel ◽  
...  
Keyword(s):  
White Matter ◽  
Corpus Callosum ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
White Matter Microstructure

D16 White matter microstructure and natural biological variation in huntington’s disease

2016 ◽  
Vol 87 (Suppl 1) ◽  
pp. A39.2-A39
Author(s):  
Helen Crawford ◽  
Douglas R Langbehn ◽  
Rachael I Scahill ◽  
Geraint Rees ◽  
Sarah J Tabrizi ◽  
...  
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Biological Variation ◽  
White Matter Microstructure

scholarly journals White matter changes in Huntington’s disease and the demyelination hypothesis: a critical review

2019 ◽  
Author(s):  
chiara casella ◽  
Claudia Metzler-Baddeley ◽  
Derek Jones ◽  
Ilona Lipp
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Biological Properties ◽  
Disease Pathogenesis ◽  
Tissue Modeling ◽  
Cortical Grey Matter ◽  
Neuroimaging Techniques

Huntington’s disease (HD) is a genetic neurodegenerative disorder, characterised by atrophy of the neostriatum, and cortical grey matter abnormalities. White matter (WM) alterations have recently been identified as a relevant pathophysiological feature of HD, but the etiology of WM degeneration, and its role in disease pathogenesis and progression remain unclear. An increasing body of research suggests that WM changes in HD are due to alterations in myelin-associated biological processes at the cellular and molecular level. This review first discusses evidence from neurochemical studies lending support to the ‘De-myelination hypothesis’ of HD, and pointing towards a role for aberrant myelination and changes in oligodendrocytes in HD WM. Next, evidence from neuroimaging studies is reviewed, the limitations of the described methodologies are discussed and suggested interpretations of findings from published studies are challenged. Although our understanding of HD-associated pathological changes in the brain will increasingly rely on neuroimaging techniques, the shortcomings of these methodologies must not be forgotten. Advances in MRI techniques and tissue modeling will enable a better characterization of the biological properties of WM microstructure, and will allow more specific monitoring of longitudinal changes noninvasively. This, in turn, will provide insight into disease pathogenesis and progression and facilitate the identification of disease-related biomarkers and the specification of outcome measures in clinical trials.

scholarly journals Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease

2016 ◽  
Vol 37 (12) ◽  
pp. 4615-4628 ◽  
Author(s):  
Michael Orth ◽  
Sarah Gregory ◽  
Rachael I Scahill ◽  
Isabella SM Mayer ◽  
Lora Minkova ◽  
...  
Keyword(s):  
White Matter ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Natural Variation ◽  
Sensory Motor
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