Statistical approach to compute a surrogate input for building physics CFD simulations through experimental measurements

2020 ◽  
Vol 20 (3) ◽  
pp. 909-936
Author(s):  
Fabio Rizzo ◽  
Paolo Zazzini ◽  
Antonio Pasculli ◽  
Alessandro Di Crescenzo

Computational Fluid Dynamics (CFD) simulations are sensitive to input uncertainties and human errors. Using real-world data as an input for CFD simulations is not rare for building physics simulations and it is still an open topic. In most cases, computer simulations using CFD are for design purposes and they aim to represent the situations occur in the real-world. The real-world parameters are commonly set based on experimental measurements. However, it is known that experimental measurements are affected by uncertainties; hence the experimental values have to be processed to calibrate numerical simulations. This paper investigates the CFD simulation calibration through experimental measurements. In particular, a statistical approach is employed to study the experimental data of inlet-outlet velocities for ten non successive days in a test-room with the purpose of assuming a surrogate day input that is the most significant of the dataset. Moreover, five different input methods on the boundary conditions of inlet velocity obtained from the experimental measurements are implemented and the accuracy of the predicted results through CFD simulations is presented. For the first input, the actual measurements of one particular day were chosen among the ten available days. For the other four, the numerical input relating to each second of the synthetic day was constructed by means of a statistical assessment of the actual measures obtained at each corresponding second of the ten actual days. The Hermite polynomial chaos expansion was selected for the last approach. Results have shown a significant variability of airflow for both experimentally measured input and output signals. By using the experimental signal expansion through Hermite polynomials the experimental and numerical values give satisfactory results.

2019 ◽  
Vol 147 (5) ◽  
pp. 1429-1445 ◽  
Author(s):  
Yuchu Zhao ◽  
Zhengyu Liu ◽  
Fei Zheng ◽  
Yishuai Jin

Abstract We performed parameter estimation in the Zebiak–Cane model for the real-world scenario using the approach of ensemble Kalman filter (EnKF) data assimilation and the observational data of sea surface temperature and wind stress analyses. With real-world data assimilation in the coupled model, our study shows that model parameters converge toward stable values. Furthermore, the new parameters improve the real-world ENSO prediction skill, with the skill improved most by the parameter of the highest climate sensitivity (gam2), which controls the strength of anomalous upwelling advection term in the SST equation. The improved prediction skill is found to be contributed mainly by the improvement in the model dynamics, and second by the improvement in the initial field. Finally, geographic-dependent parameter optimization further improves the prediction skill across all the regions. Our study suggests that parameter optimization using ensemble data assimilation may provide an effective strategy to improve climate models and their real-world climate predictions in the future.


BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tae-Hwan Kim ◽  
Hun Do Cho ◽  
Yong Won Choi ◽  
Hyun Woo Lee ◽  
Seok Yun Kang ◽  
...  

Abstract Background Since the results of the ToGA trial were published, trastuzumab-based chemotherapy has been used as the standard first-line treatment for HER2-positive recurrent or primary metastatic gastric cancer (RPMGC). However, the real-world data has been rarely reported. Therefore, we investigated the outcomes of trastuzumab-based chemotherapy in a single center. Methods This study analyzed the real-world data of 47 patients with HER2-positive RPMGC treated with trastuzumab-based chemotherapy in a single institution. Results With the median follow-up duration of 18.8 months in survivors, the median overall survival (OS) and progression-free survival were 12.8 and 6.9 months, respectively, and the overall response rate was 64%. Eastern Cooperative Oncology Group performance status 2 and massive amount of ascites were independent poor prognostic factors for OS, while surgical resection before or after chemotherapy was associated with favorable OS, in multivariate analysis. In addition, 5 patients who underwent conversion surgery after chemotherapy demonstrated an encouraging median OS of 30.8 months, all with R0 resection. Conclusions Trastuzumab-based chemotherapy in patients with HER2-positive RPMGC in the real world demonstrated outcomes almost comparable to those of the ToGA trial. Moreover, conversion surgery can be actively considered in fit patients with a favorable response after trastuzumab-based chemotherapy.


2018 ◽  
Vol 44 (8) ◽  
pp. 1191-1198 ◽  
Author(s):  
Alberto Carmona-Bayonas ◽  
Paula Jiménez-Fonseca ◽  
Isabel Echavarria ◽  
Manuel Sánchez Cánovas ◽  
Gema Aguado ◽  
...  

JAMIA Open ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 416-422
Author(s):  
Laura McDonald ◽  
Varun Behl ◽  
Vijayarakhavan Sundar ◽  
Faisal Mehmud ◽  
Bill Malcolm ◽  
...  

Abstract There is a need to understand how patients are managed in the real world to better understand disease burden and unmet need. Traditional approaches to gather these data include the use of electronic medical record (EMR) or claims databases; however, in many cases data access policies prevent rapid insight gathering. Social media may provide a potential source of real-world data to assess treatment patterns, but the limitations and biases of doing so have not yet been evaluated. Here, we assessed whether patient treatment patterns extracted from publicly available patient forums compare to results from more traditional EMR and claims databases. We observed that the 95% confidence intervals of proportions of treatments received at first, second, and third line for advanced/metastatic melanoma generated from unstructured social media data overlapped with 95% confidence intervals from proportions obtained from 1 or more traditional EMR/Claims databases. Social media may offer a valid data option to understand treatment patterns in the real world.


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