scholarly journals White Matter Connectivity in Incident Mild Cognitive Impairment: A Diffusion Spectrum Imaging Study of World Trade Center Responders at Midlife

2021 ◽  
pp. 1-11
Author(s):  
Chuan Huang ◽  
Minos Kritikos ◽  
Sean A.P. Clouston ◽  
Yael Deri ◽  
Mario Serrano-Sosa ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
World Trade ◽  
World Trade Center ◽  
Anterior Cingulate ◽  
Diffusion Spectrum Imaging ◽  
Trade Center ◽  
Spectrum Imaging ◽  
White Matter Connectivity

Background: Individuals who participated in response efforts at the World Trade Center (WTC) following 9/11/2001 are experiencing elevated incidence of mild cognitive impairment (MCI) at midlife. Objective: We hypothesized that white matter connectivity measured using diffusion spectrum imaging (DSI) would be restructured in WTC responders with MCI versus cognitively unimpaired responders. Methods: Twenty responders (mean age 56; 10 MCI/10 unimpaired) recruited from an epidemiological study were characterized using NIA-AA criteria alongside controls matched on demographics (age/sex/occupation/race/education). Axial DSI was acquired on a 3T Siemen’s Biograph mMR scanner (12-channel head coil) using a multi-band diffusion sequence. Connectometry examined whole-brain tract-level differences in white matter integrity. Fractional anisotropy (FA), mean diffusivity (MD), and quantified anisotropy were extracted for region of interest (ROI) analyses using the Desikan-Killiany atlas. Results: Connectometry identified both increased and decreased connectivity within regions of the brains of responders with MCI identified in the corticothalamic pathway and cortico-striatal pathway that survived adjustment for multiple comparisons. MCI was also associated with higher FA values in five ROIs including in the rostral anterior cingulate; lower MD values in four ROIs including the left rostral anterior cingulate; and higher MD values in the right inferior circular insula. Analyses by cognitive domain revealed nominal associations in domains of response speed, verbal learning, verbal retention, and visuospatial learning. Conclusions: WTC responders with MCI at midlife showed early signs of neurodegeneration characterized by both increased and decreased white matter diffusivity in regions commonly affected by early-onset Alzheimer’s disease.

scholarly journals Longitudinal characterization of mild cognitive impairment and dementia in World Trade Center responders at midlife

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Sean A.P. Clouston ◽  
Frank P Mann ◽  
Erica D Diminich ◽  
Minos Kritikos ◽  
Alison Pellecchia ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center

P4-161: INCIDENCE OF MILD COGNITIVE IMPAIRMENT IN A SAMPLE OF WORLD TRADE CENTER RESPONDERS: THE LONG-TERM IMPLICATIONS OF RE-EXPERIENCING THE EVENT

2006 ◽  
Vol 14 (7S_Part_28) ◽  
pp. P1501-P1501
Author(s):  
Sean Clouston ◽  
Roman Kotov ◽  
Yael Deri ◽  
Robert H. Pietrzak ◽  
Marcus Richards ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center

scholarly journals White Matter Connectivity and Gray Matter Volume Changes Following Donepezil Treatment in Patients With Mild Cognitive Impairment: A Preliminary Study Using Probabilistic Tractography

2021 ◽  
Vol 12 ◽  
Author(s):  
Gwang-Won Kim ◽  
Shin-Eui Park ◽  
Kwangsung Park ◽  
Gwang-Woo Jeong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
Probabilistic Tractography ◽  
Volume Changes ◽  
White Matter Connectivity ◽  
The Impact

The donepezil treatment is associated with improved cognitive performance in patients with mild cognitive impairment (MCI), and its clinical effectiveness is well-known. However, the impact of the donepezil treatment on the enhanced white matter connectivity in MCI is still unclear. The purpose of this study was to evaluate the thalamo-cortical white matter (WM) connectivity and cortical thickness and gray matter (GM) volume changes in the cortical regions following donepezil treatment in patients with MCI using probabilistic tractography and voxel-based morphometry. Patients with MCI underwent magnetic resonance examinations before and after 6-month donepezil treatment. Compared with healthy controls, patients with MCI showed decreased WM connectivity of the thalamo-lateral prefrontal cortex, as well as reduced thickness in the medial/lateral orbitofrontal cortices (p < 0.05). The thalamo-lateral temporal cortex connectivity in patients with MCI was negatively correlated with Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) (r = −0.76, p = 0.01). The average score of the Korean version of the mini-mental state examination (K-MMSE) in patients with MCI was improved by 7.9% after 6-months of donepezil treatment. However, the patterns of WM connectivity and brain volume change in untreated and treated patients were not significantly different from each other, resulting from multiple comparison corrections. These findings will be valuable in understanding the neurophysiopathological mechanism on MCI as a prodromal phase of Alzheimer's disease in connection with brain functional connectivity and morphometric change.

scholarly journals Differential White Matter Connectivity in Early Mild Cognitive Impairment According to CSF Biomarkers

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91400 ◽  
Author(s):  
Jae-Sung Lim ◽  
Young Ho Park ◽  
Jae-Won Jang ◽  
So Yong Park ◽  
SangYun Kim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Csf Biomarkers ◽  
White Matter Connectivity ◽  
Early Mild Cognitive Impairment

scholarly journals BIOLOGICAL MARKERS OF AGING: CHRONIC STRESS AND COGNITIVE IMPAIRMENT IN RESPONDERS FROM THE WORLD TRADE CENTER

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S93-S94
Author(s):  
Erica D Diminich ◽  
Sean Clouston ◽  
Stacey B Scott ◽  
Nikhil Palekar ◽  
Erica D santiago ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
World Trade ◽  
Ptsd Symptom ◽  
World Trade Center ◽  
Post Traumatic Stress ◽  
The World ◽  
Trade Center ◽  
Post Traumatic

Abstract Post-traumatic Stress Disorder (PTSD) is a stress related syndrome. Chronic PTSD has increasingly been associated with poor health outcomes, neurodegeneration and risk for cognitive impairment (CI). However, the biological mechanisms underlying the development and maintenance of symptoms and potential associations in accelerating aging are not well understood. The aim of this study was to evaluate whether specific biomarkers influence functional limitations and cognitive impairment in rescue and recovery workers (i.e. responders) from the attacks on the World Trade Center (WTC) in New York. Plasma biomarkers were collected during annual health and wellness visits at the WTC responder clinic between 2012 and 2014. Short Physical Performance Battery (SPPB) and clinical data were examined with prospective PTSD symptom scores collected during participant’s initial enrollment into the parent study as early as 2002. We examined the relationship between cardiovascular (Diastolic Blood Pressure, Systolic Blood Pressure, pulse rate), metabolic (Total Cholesterol, HDL cholesterol, Triglycerides, Glucose, Body Mass Index) and inflammation markers (Albumin, White Blood Count) with Post-traumatic Stress Disorder (PTSD), cognitive functioning (Montreal Cognitive Assessment) and frailty (Short Physical Performance Battery) in responders from the World Trade Center (WTC). We first examined correlations between biomarkers, PTSD symptom severity, PTSD dimensions, cognitive functioning and frailty. We then conducted multivariate regression analyses. In models adjusted for potential confounders, among N=1,045 responders, elevated PTSD was strongly associated with increased frailty, cardiovascular dysregulation and mild cognitive impairment. Current work is ongoing to identify trajectories of change in cognition with frailty and biological factors.

scholarly journals Cognitive impairment among World Trade Center responders: Long‐term implications of re‐experiencing the 9/11 terrorist attacks

2016 ◽  
Vol 4 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Sean A.P. Clouston ◽  
Roman Kotov ◽  
Robert H. Pietrzak ◽  
Benjamin J. Luft ◽  
Adam Gonzalez ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
World Trade ◽  
World Trade Center ◽  
Terrorist Attacks ◽  
Trade Center
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