Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

2012 ◽  
Vol 33 (s1) ◽  
pp. S123-S139 ◽  
Author(s):  
Jian-Zhi Wang ◽  
Yi-Yuan Xia ◽  
Inge Grundke-Iqbal ◽  
Khalid Iqbal
Keyword(s):  
Molecular Mechanism ◽  
Neurofibrillary Degeneration ◽  
Abnormal Hyperphosphorylation

scholarly journals Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target

2006 ◽  
Vol 2006 ◽  
pp. 1-11 ◽  
Author(s):  
Cheng-Xin Gong ◽  
Fei Liu ◽  
Inge Grundke-Iqbal ◽  
Khalid Iqbal
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Phosphorylation ◽  
Molecular Mechanism ◽  
Therapeutic Target ◽  
Neurofibrillary Degeneration ◽  
Tau Pathology ◽  
Abnormal Hyperphosphorylation ◽  
Promising Therapeutic Target

Studies during the last two decades have provided new insights into the molecular mechanism of Alzheimer's disease (AD). One of the milestone findings in AD research was the demonstration that neurofibrillary degeneration characterized by tau pathology is central to the pathogenesis of AD and other tauopathies and that abnormal hyperphosphorylation of tau is pivotal to neurofibrillary degeneration. This article reviews the recent research advances in tau pathology and the underlying dysregulation of the protein phosphorylation/dephosphorylation system. An updated model of the mechanism of neurofibrillary degeneration is also presented, and a promising therapeutic target to treat AD by correcting dysregulation of protein phosphorylation/dephosphorylation is discussed.

299 Abnormal hyperphosphorylation of tau: An early and most significant deleterious event in neurofibrillary degeneration

1996 ◽  
Vol 17 (4) ◽  
pp. S75
Author(s):  
I. Grundke-Iqbal ◽  
T. Tanaka ◽  
Y.-C. Tung ◽  
N. Haque ◽  
Khalid Iqbal
Keyword(s):  
Neurofibrillary Degeneration ◽  
Abnormal Hyperphosphorylation

Additional evidence for AQP1 vesicle trafficking as a molecular mechanism for ductal bile secretion

2001 ◽  
Vol 120 (5) ◽  
pp. A91-A91
Author(s):  
P TIETZ ◽  
P SPLINTER ◽  
M MCNIVEN ◽  
R HUEBERT ◽  
N LARUSSO
Keyword(s):  
Molecular Mechanism ◽  
Vesicle Trafficking ◽  
Bile Secretion

Hypoxia/Reoxygenation on human myometrial and decidual cells: A molecular mechanism involved in preterra labor

1998 ◽  
Vol 5 (1) ◽  
pp. 187A-187A
Author(s):  
J CARVAJAL ◽  
S KATO ◽  
J SAEZ ◽  
F LEIGHTON ◽  
G VALENZUELA ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Decidual Cells ◽  
Hypoxia Reoxygenation

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

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