Association of K832R and R952K SNPs of Wilson's Disease Gene with Alzheimer's Disease

2012 ◽  
Vol 29 (4) ◽  
pp. 913-919 ◽  
Author(s):  
Serena Bucossi ◽  
Renato Polimanti ◽  
Stefania Mariani ◽  
Mariacarla Ventriglia ◽  
Cristian Bonvicini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Wilson’S Disease ◽  
Disease Gene ◽  
Wilson's Disease

scholarly journals Paradigm Shift in Treatment of Alzheimer's Disease: Zinc Therapy Now a Conscientious Choice for Care of Individual Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Tjaard U. Hoogenraad
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cortical Neurons ◽  
Wilson’S Disease ◽  
Chelation Therapy ◽  
Wilson's Disease ◽  
Evidence Based ◽  
Juvenile Form ◽  
Copper Toxicosis ◽  
Age Related

Breakthrough in treatment of Alzheimer's disease with a shift from irrational dangerous chelation therapy to rational safe evidence based oral zinc therapy. Evidence based medicine: After synthesizing the best available clinical evidence I conclude that oral zinc therapy is a conscientious choice for treatment of free copper toxicosis in individual patients with Alzheimer's disease. Hypothesis 1: Age related free copper toxicosis is a causal factor in pathogenesis of Alzheimer's disease. There are 2 neurodegenerative diseases with abnormalities in copper metabolism: (a) the juvenile form with degeneration in the basal ganglia (Wilson's disease) and (b) the age related form with cortical neurodegeneration (Alzheimer's disease). Initially the hypothesis has been that neurodegeneration was caused by accumulation of copper in the brain but later experiences with treatment of Wilson's disease led to the conviction that free plasma copper is the toxic form of copper: it catalyzes amyloid formation thereby generating oxidative stress, free radicals and degeneration of cortical neurons. Hypothesis 2: Oral zinc therapy is an effective and safe treatment of free copper toxicosis in Alzheimer's disease. Proposed dosage: 50 mg elementary zinc/day. Warning: Chelation therapy is irrational and dangerous in treatment of copper toxicosis in Alzheimer's disease.

Wilson’s Disease Presenting With Haematuria and Swelling

2012 ◽  
Vol 23 (1) ◽  
pp. 51-52
Author(s):  
Pradip Kumar Dutta ◽  
Syed Md Jabed ◽  
Md Abul Kashem ◽  
Saibal Das ◽  
Md Nurul Huda
Keyword(s):  
Fanconi Syndrome ◽  
Wilson’S Disease ◽  
Disease Gene ◽  
Wilson's Disease ◽  
Late Diagnosis ◽  
Nephritic Syndrome ◽  
Rare Manifestation ◽  
Acute Nephritic Syndrome

Wilson’s disease gene located in Chromosime 3 is also expressed in Kidneys. So Wilson’s disease may have renal manifestations either as primary even or secondarily as Hepato renal syndrome. Patients commonly manifest as Fanconi syndrome or Urolithiasis. Haematuria and proteinuria is a rare manifestation. Here we are presenting a case who initially presented with haematuria and proteinuria (Acute nephritic syndrome) which masked features of Wilson’s disease and late diagnosis. JCMCTA 2012; 23(1): 51-52

Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats

1995 ◽  
Vol 70 (1) ◽  
pp. 25-33
Author(s):  
Takao ONO ◽  
Risaku FUKUMOTO ◽  
Yasumitsu KONDOH ◽  
Michihiro C. YOSHIDA
Keyword(s):  
Wilson’S Disease ◽  
Disease Gene ◽  
Wilson's Disease ◽  
Lec Rats

Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein

1997 ◽  
Vol 3 (3) ◽  
pp. 328-332 ◽  
Author(s):  
A. Weidemann ◽  
K. Paliga ◽  
U. Dürrwang ◽  
C. Czech ◽  
G. Evin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Disease Gene ◽  
Precursor Protein ◽  
Gene Products ◽  
Presenilin 2 ◽  
Β Amyloid

scholarly journals IC-O1-02: Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent?

2013 ◽  
Vol 9 ◽  
pp. P3-P4
Author(s):  
Kirsi Kinnunen ◽  
Natalie Ryan ◽  
David Cash ◽  
António Bastos Leite ◽  
Sarah Finnegan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autosomal Dominant ◽  
Disease Gene ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease
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