PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

2021 ◽  
pp. 1-7
Author(s):  
Fan Chen ◽  
Yan Zhang ◽  
Longcai Wang ◽  
Tao Wang ◽  
Zhifa Han ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Large Scale

We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer’s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59–0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

scholarly journals Genetic Association Study on Colony-Stimulating Factor 1 in Alzheimer’s Disease

2006 ◽  
Vol 3 (6) ◽  
pp. 334-337 ◽  
Author(s):  
M. Axel Wollmer ◽  
Roger M. Nitsch ◽  
Christoph Hock ◽  
Andreas Papassotiropoulos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over

2000 ◽  
Vol 292 (3) ◽  
pp. 195-198 ◽  
Author(s):  
Liisa Myllykangas ◽  
Tuomo Polvikoski ◽  
Raimo Sulkava ◽  
Auli Verkkoniemi ◽  
Pentti Tienari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cardiovascular Risk ◽  
Association Study ◽  
Cardiovascular Risk Factors ◽  
Genetic Association ◽  
Genetic Association Study

Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: A genetic association study

2009 ◽  
Vol 465 (3) ◽  
pp. 272-275 ◽  
Author(s):  
Kyungsook Ahn ◽  
Ju Hee Song ◽  
Doh Kwan Kim ◽  
Moon Ho Park ◽  
Sangmee A. Jo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genetic Association ◽  
Gene Polymorphisms ◽  
Genetic Association Study ◽  
Late Onset ◽  
Korean Population

P3-204: Genetic association study to the amyloid plaque-associated protein gene COL25A1 in Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T580-T580
Author(s):  
Behnosh F. Bjork ◽  
Charlotte Forsell ◽  
Lena Lilius ◽  
Karin Axelman ◽  
Susanne Froelich Fabre ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Protein Gene ◽  
Amyloid Plaque

Finding susceptible and protective interaction patterns in large-scale genetic association study

2017 ◽  
Vol 11 (3) ◽  
pp. 541-554 ◽  
Author(s):  
Yuan Li ◽  
Yuhai Zhao ◽  
Guoren Wang ◽  
Xiaofeng Zhu ◽  
Xiang Zhang ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Large Scale ◽  
Interaction Patterns

scholarly journals Genetically increased serum calcium levels reduce Alzheimer’s disease risk

2018 ◽  
Author(s):  
Qinghua Jiang ◽  
Yang Hu ◽  
Shuilin Jin ◽  
Guiyou Liu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Serum Calcium ◽  
Genetic Variants ◽  
Large Scale ◽  
Mendelian Randomization ◽  
European Descent ◽  
Gwas Dataset ◽  
Weighted Median

AbstractIMPORTANCE Alzheimer’s disease (AD) is the leading cause of disability in the elderly. It has been a long time about the calcium hypothesis of AD on the basis of emerging evidence since 1994. However, most studies focused on the association between calcium homeostasis and AD, and concerned the intracellular calcium concentration. Only few studies reported reduced serum calcium levels in AD. Until now, it remains unclear whether serum calcium levels are genetically associated with AD risk.OBJECTIVE To evaluate the genetic association between increased serum calcium levels and AD riskDESIGN, SETTING, AND PARTICIPANTS We performed a Mendelian randomization study to investigate the association of increased serum calcium with AD risk using the genetic variants from the large-scale serum calcium genome-wide association study (GWAS) dataset (N=61,079 individuals of European descent) and the large-scale AD GWAS dataset (N=54,162 individuals including 17,008 AD cases and 37,154 controls of European descent). Inverse-variance weighted meta-analysis (IVW) was used to provide a combined estimate of the genetic association. Meanwhile, we selected the weighted median regression and MR-Egger regression as the complementary analysis methods to examine the robustness of the IVW estimate.EXPOSURES Genetic predisposition to increased serum calcium levelsMAIN OUTCOMES AND MEASURES The risk of AD.RESULTS We selected 6 independent genetic variants influencing serum calcium levels as the instrumental variables. IVW analysis showed that a genetically increased serum calcium level (per 1 standard deviation (SD) increase 0.5-mg/dL) was significantly associated with a reduced AD risk (OR=0.56, 95% CI: 0.34-0.94, P=5.00E-03). Meanwhile, both the weighted median estimate (OR=0.60, 95% CI: 0.34-1.06, P=0.08) and MR-Egger estimate (OR=0.66, 95% CI: 0.26-1.67, P=0.381) were consistent with the IVW estimate in terms of direction and magnitude.CONCLUSIONS AND RELEVANCE We provided evidence that genetically increased serum calcium levels could reduce the risk of AD. Meanwhile, randomized controlled study should be further conducted to assess the effect of serum calcium levels on AD risk, and further clarify whether diet calcium intake or calcium supplement, or both could reduce the risk of AD.Key PointsQuestion Is there a genetic relationship between elevated serum calcium levels and the risk of Alzheimer’s disease?Findings This Mendelian randomization study showed that the genetically increased serum calcium levels were associated with the reduced risk of Alzheimer’s disease.Meaning These findings provide evidence that genetically increased serum calcium levels could reduce the risk of Alzheimer’s disease.

A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine

2006 ◽  
Vol 119 (6) ◽  
pp. 611-616 ◽  
Author(s):  
Taizo Horikoshi ◽  
Koichi Maeda ◽  
Yoshiharu Kawaguchi ◽  
Kazuhiro Chiba ◽  
Kanji Mori ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Large Scale ◽  
Posterior Longitudinal Ligament

scholarly journals A Large-scale genetic association study of esophageal adenocarcinoma risk

2010 ◽  
Vol 31 (7) ◽  
pp. 1259-1263 ◽  
Author(s):  
Chen-yu Liu ◽  
Michael C. Wu ◽  
Feng Chen ◽  
Monica Ter-Minassian ◽  
Kofi Asomaning ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Association ◽  
Esophageal Adenocarcinoma ◽  
Genetic Association Study ◽  
Large Scale
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