scholarly journals Characterization of Insulin Degrading Enzyme and Other Amyloid-β Degrading Proteases in Human Serum: A Role in Alzheimer's Disease?

2012 ◽  
Vol 29 (2) ◽  
pp. 329-340 ◽  
Author(s):  
Zhiheng Liu ◽  
Haihao Zhu ◽  
Guang Guang Fang ◽  
Kathryn Walsh ◽  
Mkaya Mwamburi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Serum ◽  
Amyloid Β ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme

scholarly journals The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease

Oncotarget ◽  
2018 ◽  
Vol 9 (74) ◽  
pp. 33884-33895 ◽  
Author(s):  
Soren Hayrabedyan ◽  
Krassimira Todorova ◽  
Marialuigia Spinelli ◽  
Eytan R. Barnea ◽  
Martin Mueller
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Potential Treatment ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
The Core ◽  
Core Sequence

Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-Analysis

2018 ◽  
Vol 15 (7) ◽  
pp. 610-617 ◽  
Author(s):  
Huifeng Zhang ◽  
Dan Liu ◽  
Huanhuan Huang ◽  
Yujia Zhao ◽  
Hui Zhou
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Enzyme Activity ◽  
Protein Level ◽  
Senile Plaque ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
Significant Difference

Background: β-amyloid (Aβ) accumulates abnormally to senile plaque which is the initiator of Alzheimer's disease (AD). As one of the Aβ-degrading enzymes, Insulin-degrading enzyme (IDE) remains controversial for its protein level and activity in Alzheimer's brain. Methods: The electronic databases PubMed, EMBASE, The Cochrane Library, OVID and Sinomed were systemically searched up to Sep. 20th, 2017. And the published case-control or cohort studies were retrieved to perform the meta-analysis. Results: Seven studies for IDE protein level (AD cases = 293; controls = 126), three for mRNA level (AD cases = 138; controls = 81), and three for enzyme activity (AD cases = 123; controls = 75) were pooling together. The IDE protein level was significantly lower in AD cases than in controls (SMD = - 0.47, 95% CI [-0.69, -0.24], p < 0.001), but IDE mRNA and enzyme activity had no significant difference (SMD = 0.02, 95% CI [-0.40, 0.43] and SMD = 0.06, 95% CI [-0.41, 0.53] respectively). Subgroup analyses found that IDE protein level was decreased in both cortex and hippocampus of AD cases (SMD = -0.43, 95% CI [-0.71, -0.16], p = 0.002 and SMD = -0.53, 95% CI [-0.91, -0.15], p = 0.006 respectively). However, IDE mRNA was higher in cortex of AD cases (SMD = 0.71, 95% CI [0.14, 1.29], p = 0.01), not in hippocampus (SMD = -0.26, 95% CI [-0.58, 0.06]). Conclusions: Our results indicate that AD patients may have lower IDE protease level. Further relevant studies are still needed to verify whether IDE is one of the factors affecting Aβ abnormal accumulation and throw new insights for AD detection or therapy.

Alzheimer's disease amyloid β-clipping enzyme (APP secretase): Identification, purification, and characterization of the enzyme

1991 ◽  
Vol 177 (1) ◽  
pp. 377-387 ◽  
Author(s):  
Kazuhiko Tagawa ◽  
Tatsuhide Kunishita ◽  
Kei Maruyama ◽  
Kazuaki Yoshikawa ◽  
Eiki Kominami ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Purification And Characterization

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease

2001 ◽  
Vol 109 (6) ◽  
pp. 646-652 ◽  
Author(s):  
Richard Abraham ◽  
Amanda Myers ◽  
Fabienne Wavrant-DeVrieze ◽  
Marian L. Hamshere ◽  
Hollie V. Thomas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Disequilibrium ◽  
Late Onset ◽  
Enzyme Locus ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme

P1-068: Cognitive phenotypes in Alzheimer's disease and insulin degrading enzyme gene variants

2010 ◽  
Vol 6 ◽  
pp. S193-S193
Author(s):  
Emma R.L.C. Vardy ◽  
Kristelle Brown ◽  
Cheryl L. Stopford ◽  
Noor Kalsheker ◽  
David Neary ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Variants ◽  
Insulin Degrading Enzyme ◽  
Enzyme Gene ◽  
Degrading Enzyme

Mass Spectrometric Characterization of Amyloid-β Species in the 7PA2 Cell Model of Alzheimer's Disease

2012 ◽  
Vol 33 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Erik Portelius ◽  
Maria Olsson ◽  
Gunnar Brinkmalm ◽  
Ulla Rüetschi ◽  
Niklas Mattsson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Amyloid Β ◽  
Mass Spectrometric ◽  
Model Of Alzheimer’S Disease ◽  
7Pa2 Cell
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