APOE ε4 Allele Status in Korean Dementia Patients with Severe White Matter Hyperintensities

2011 ◽  
Vol 24 (3) ◽  
pp. 519-524 ◽  
Author(s):  
Yun Jeong Hong ◽  
Bora Yoon ◽  
Yong S. Shim ◽  
A-Hyun Cho ◽  
Hae-Eun Shin ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Apoe Ε4 ◽  
Dementia Patients ◽  
Allele Status ◽  
Ε4 Allele

[P1-410]: HIGHER PREVALENCE OF CEREBRAL WHITE MATTER HYPERINTENSITIES IN HOMOZYGOUS APOE-ε4 ALLELE CARRIERS AGED 45 TO 75: RESULTS FROM THE ALFA STUDY

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P432-P433
Author(s):  
Santiago Rojas ◽  
Anna Brugulat ◽  
Nuria Bargalló ◽  
Carolina Minguillon ◽  
Alan Tucholka ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Cerebral White Matter ◽  
Apoe Ε4 ◽  
Ε4 Allele

scholarly journals Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects

2019 ◽  
Vol 24 ◽  
pp. 101983 ◽  
Author(s):  
Grégory Operto ◽  
José Luis Molinuevo ◽  
Raffaele Cacciaglia ◽  
Carles Falcon ◽  
Anna Brugulat-Serrat ◽  
...  
Keyword(s):  
White Matter ◽  
Interactive Effect ◽  
Middle Aged ◽  
Cognitively Normal ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Aged Subjects ◽  
Effect Of Age

P1-275: Does APOE-ε4 confer risk for Alzheimer's disease through regionally distributed white matter hyperintensities?

2013 ◽  
Vol 9 ◽  
pp. P254-P254 ◽  
Author(s):  
Adam Brickman ◽  
Atul Narkhede ◽  
Nicole Schupf ◽  
Jose Luchsinger ◽  
Jennifer Manly ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Apoe Ε4

Inheritance of the ApoE ε4 Allele Increases the Rate of Brain Atrophy in Dementia Patients

1999 ◽  
Vol 10 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Lars-Olof Wahlund ◽  
Per Julin ◽  
Lars Lannfelt ◽  
Johan Lindqvist ◽  
Leif Svensson
Keyword(s):  
Brain Atrophy ◽  
Apoe Ε4 ◽  
Dementia Patients ◽  
Ε4 Allele

Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India

2016 ◽  
Vol 42 (5-6) ◽  
pp. 255-264 ◽  
Author(s):  
P.S. Jairani ◽  
P.M. Aswathy ◽  
Srinivas Gopala ◽  
Joe Verghese ◽  
P.S. Mathuranath
Keyword(s):  
Disease Risk ◽  
Strong Association ◽  
Multivariate Logistic Regression Analysis ◽  
Lewy Bodies ◽  
Southern India ◽  
Control Group ◽  
Apoe Ε4 ◽  
Dementia Patients ◽  
Dementia Risk ◽  
Ε4 Allele

Background: This study delineates the role of the interaction of apolipoprotein E (APOE) and MAPT alleles in contributing to disease risks of dementia in a southern Indian population. Methods: A sample of 419 patients comprising Alzheimer's disease (AD; n = 156), mild cognitive impairment (MCI; n = 87), frontotemporal dementia (FTD; n = 127), vascular dementia (VD; n = 37), and dementia with Lewy bodies (DLB; n = 12) was analysed in comparison with a control group (n = 138). APOE genotyping and MAPT haplotyping were performed on all study subjects. Results: Multivariate logistic regression analysis showed that variability on the APOE locus influenced the relative risk of dementia in the study population. The APOE ε4 allele increased the disease risk most significantly for AD (OR = 3.468, p < 0.0001) and MCI (OR = 2.901, p < 0.0001). The APOE ε2 allele remained protective for AD (OR = 0.205, p < 0.05). For FTD, VD, and DLB, the APOE ε4 allele was ineffectual in modulating disease risk. The MAPT H1 haplotype was not an overrepresented marker of neurodegenerative diseases. The H1H1 genotype had an additive effect in contributing to either disease risk in combination with the APOE ε4 allele or protection in combination with the APOE ε2 or ε3 allele. Conclusions: This study is a reappraisal of the strong association of APOE variability with AD in southern India when compared to other dementia groups, while the transcriptional differences between MAPT haplotypes have a limited role in Indian dementia patients.

scholarly journals APOE ε4 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role?

2014 ◽  
Vol 10 (6) ◽  
pp. 619-629 ◽  
Author(s):  
Adam M. Brickman ◽  
Nicole Schupf ◽  
Jennifer J. Manly ◽  
Yaakov Stern ◽  
José A. Luchsinger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Apoe Ε4

scholarly journals The Association between Polygenic Hazard and Markers of Alzheimer’s Disease Following Stratification for APOE Genotype

2020 ◽  
Vol 17 (7) ◽  
pp. 667-679
Author(s):  
Matteo De Marco ◽  
Riccardo Manca ◽  
Janine Kirby ◽  
Guillaume M. Hautbergue ◽  
Daniel J. Blackburn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Executive Functioning ◽  
Grey Matter ◽  
Linear Models ◽  
Apoe Genotype ◽  
Apoe Ε4 ◽  
Allele Status ◽  
Ε4 Allele ◽  
Clinical Profiles

Background: Research indicates that polygenic indices of risk of Alzheimer’s disease are linked to clinical profiles. Objective: Given the “genetic centrality” of the APOE gene, we tested whether this held true for both APOE-ε4 carriers and non-carriers. Methods: A polygenic hazard score (PHS) was extracted from 784 non-demented participants recruited in the Alzheimer’s Disease Neuroimaging Initiative and stratified by APOE ε4 status. Datasets were split into sub-cohorts defined by clinical (unimpaired/MCI) and amyloid status (Aβ+/Aβ-). Linear models were devised in each sub-cohort and for each APOE-ε4 status to test the association between PHS and memory, executive functioning and grey-matter volumetric maps. Results: PHS predicted memory and executive functioning in ε4ε3 MCI patients, memory in ε3ε3 MCI patients, and memory in ε4ε3 Aβ+ participants. PHS also predicted volume in sensorimotor regions in ε3ε3 Aβ+ participants. Conclusion: The link between polygenic hazard and neurocognitive variables varies depending on APOE-ε4 allele status. This suggests that clinical phenotypes might be influenced by complex genetic interactions.

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