scholarly journals Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review

2020 ◽  
Vol 78 (4) ◽  
pp. 1519-1546
Author(s):  
J.Q. Alida Chen ◽  
Philip Scheltens ◽  
Colin Groot ◽  
Rik Ossenkoppele
Keyword(s):  
Systematic Review ◽  
Cognitive Decline ◽  
Green Tea ◽  
Epidemiologic Studies ◽  
Cognitively Impaired ◽  
Caffeine Consumption ◽  
Positive Study ◽  
Study Characteristics ◽  
The Relationship ◽  
Positive Results

Background: Epidemiologic studies have provided inconclusive evidence for a protective effect of caffeine consumption on risk of dementia and cognitive decline. Objective: To summarize literature on the association between caffeine and 1) the risk of dementia and/or cognitive decline, and 2) cognitive performance in individuals with mild cognitive impairment (MCI) or dementia, and 3) to examine the effect of study characteristics by categorizing studies based on caffeine source, quantity and other possible confounders. Methods: We performed a systematic review of caffeine effects by assessing overall study outcomes; positive, negative or no effect. Our literature search identified 61 eligible studies performed between 1990 and 2020. Results: For studies analyzing the association between caffeine and the risk of dementia and/or cognitive decline, 16/57 (28%) studies including a total of 40,707/153,070 (27%) subjects reported positive study outcomes, and 30/57 (53%) studies including 71,219/153,070 (47%) subjects showed positive results that were dependent on study characteristics. Caffeine effects were more often positive when consumed in moderate quantities (100–400 mg/d), consumed in coffee or green tea, and in women. Furthermore, four studies evaluated the relationship between caffeine consumption and cognitive function in cognitively impaired individuals and the majority (3/4 [75% ]) of studies including 272/289 subjects (94%) reported positive outcomes. Conclusion: This review suggests that caffeine consumption, especially moderate quantities consumed through coffee or green tea and in women, may reduce the risk of dementia and cognitive decline, and may ameliorate cognitive decline in cognitively impaired individuals.

scholarly journals MIGRAINE: A POSSIBLE CAUSE FOR COGNITIVE DECLINE

2017 ◽  
Vol 10 (5) ◽  
pp. 228
Author(s):  
Poornima Kn
Keyword(s):  
Cognitive Decline ◽  
Epidemiologic Studies ◽  
Research Centre ◽  
College Hospital ◽  
Medical College ◽  
Conflicting Result ◽  
International Headache Classification ◽  
The Relationship ◽  
Card Test ◽  
Possible Cause

Objectives:Migraine is the second most common type of headache and seventh most disabling disease worldwide. In general, obesity is often related to headache disorders in several clinical and epidemiologic studies. Obese migraine patients may have an increased attack frequency due to increase in inflammatory response. Cognitive decline is the major pitfall of migraine disorder and there exists a conflicting result between cognition and migraine and the effect of Body Mass Index (BMI) on migraine. So this study is done to find out the relationship between cognition and migraine and its association with BMI.Methods:The study protocol was approved by the ethical committee of SRM Medical College Hospital & Research Centre. The study group consisted of 30 migraine patients and 30 healthy controls aged between 18-40 years of age. Informed consent was obtained from all the participants. Diagnosis of migraine was made using the criteria of 2nd edition of International Headache Classification (IHC). Patients affected by Diabetes mellitus, Hypertension, allergy, inflammation, infection or immune disorders were excluded. Height and weight of the subjects were taken to calculate the BMI. Cognitive tests such as stroop interference trial & trial making tests (A&B) were done to evaluate working memory, mental flexibility and attention.Results:Compared to controls, cases took more time for performing stroop colour card test (106.40 ± 15.87 seconds vs. 132.17±7.027seconds, p<0.001) and trial making pattern B (54.77± 8.169 seconds vs. 56.23 ± 23.457seconds, p=0.004). Among the migraine subjects, obese individuals had an increased frequency of migraine attack per month (Correlation coefficient r=0.797)Conclusion:Cognitive decline in migraine is one of the underestimated problems in migraine. Identifying such problems early can prevent major consequences in day to day activities of migraine patients. Since there is an increased frequency of migraine with increase in BMI, obese migraine subjects can be recommended to do regular exercises.Key words: Migraine, Cognition, Stroop test, Obesity.

scholarly journals Does Caffeine Intake Increase the Incidence of Tinnitus? A Systematic Review

2020 ◽  
Author(s):  
Sattam M. Aljuaid ◽  
Ahmad A. Mirza ◽  
Lura A. Habib ◽  
Lujain A. AlHarthi ◽  
Bashayer M. Alansari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Population Based ◽  
Caffeine Intake ◽  
Contributory Factor ◽  
High Dose ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Current Review ◽  
Prospective Cohorts ◽  
The Relationship

Abstract Introduction Excessive caffeine intake has been thought to be a contributory factor for tinnitus. However, there has been no systematic review to elucidate the causal relationship between caffeine intake and the incidence of tinnitus. Objectives We performed the current review aiming at evaluating the evidence from the current literature for the relationship between caffeine intake and the incidence of tinnitus. Data Synthesis Databases including PubMed, Scopus, and Google scholar were searched for relevant articles. A total of 142 studies were screened for eligibility, of which four articles met our inclusion criteria: two were prospective cohorts and two were cross-sectional studies. Although one study found no association between caffeine consumption and the incidence of tinnitus, an inverse relationship was reported by two population-based studies. Concerning patients with preexisting tinnitus, reduction of caffeine intake in a subset who consumed 150 ml to 300 ml/day of coffee yielded a favorable outcome in tinnitus severity. However, those with higher dose intake were less prone to have improvement in the severity of tinnitus. Conclusion Although the current review was inconclusive, it appears that the incidence of tinnitus in previously unaffected individuals might be prevented by a high dose of caffeine intake. However, in preexisting tinnitus, a high dose of caffeine may adversely interfere with the efficacy of caffeine reduction.

scholarly journals Epidemiology of Adolescent Rugby Injuries: A Systematic Review

2011 ◽  
Vol 46 (5) ◽  
pp. 555-565 ◽  
Author(s):  
Christopher Bleakley ◽  
Mark Tully ◽  
Sean O'Connor
Keyword(s):  
Systematic Review ◽  
Upper Limb ◽  
Epidemiologic Studies ◽  
Rugby Union ◽  
Medical Attention ◽  
Patient Specific ◽  
Time Loss ◽  
Knee Ligament ◽  
Study Characteristics ◽  
Knee Ligament Injuries

Objective: Despite recent increases in the volume of research in professional rugby union, there is little consensus on the epidemiology of injury in adolescent players. We undertook a systematic review to determine the incidence, severity, and nature of injury in adolescent rugby union players. Data Sources: In April 2009, we performed a computerized literature search on PubMed, Embase, and Cochrane Controlled Trials Register (via Ovid). Population-specific and patient-specific search terms were combined in the form of MEDLINE subject headings and key words (wound$ and injur$, rugby, adolescent$). These were supplemented with related-citation searches on PubMed and bibliographic tracking of primary and review articles. Study Selection: Prospective epidemiologic studies in adolescent rugby union players. Data Synthesis: A total of 15 studies were included, and the data were analyzed descriptively. Two independent reviewers extracted key study characteristics regarding the incidence, severity, and nature of injuries and the methodologic design. Conclusions: Wide variations existed in the injury definitions and data collection procedures. The incidence of injury necessitating medical attention varied with the definition, from 27.5 to 129.8 injuries per 1000 match hours. The incidence of time-loss injury (&gt;7 days) ranged from 0.96 to 1.6 per 1000 playing hours and from 11.4/1000 match hours (&gt;1 day) to 12–22/1000 match hours (missed games). The highest incidence of concussion was 3.3/1000 playing hours. No catastrophic injuries were reported. The head and neck, upper limb, and lower limb were all common sites of injury, and trends were noted toward greater time loss due to upper limb fractures or dislocations and knee ligament injuries. Increasing age, the early part of the playing season, and the tackle situation were most closely associated with injury. Future injury-surveillance studies in rugby union must follow consensus guidelines to facilitate interstudy comparisons and provide further clarification as to where injury- prevention strategies should be focused.

scholarly journals Can Physical Activity Reduce the Risk of Cognitive Decline in Apolipoprotein e4 Carriers? A Systematic Review

2021 ◽  
Vol 18 (14) ◽  
pp. 7238
Author(s):  
Jose Luis Perez-Lasierra ◽  
Jose Antonio Casajús ◽  
José Antonio Casasnovas ◽  
Jose Miguel Arbones-Mainar ◽  
Antonio Lobo ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Longitudinal Study ◽  
General Population ◽  
Cognitive Decline ◽  
Protective Factor ◽  
Scientific Evidence ◽  
Partial Support ◽  
Longitudinal Study Design ◽  
The Relationship

Physical activity (PA) reduces the risk of cognitive decline (CD) in the general population. However, little is known about whether the presence of the apolipoprotein E epsilon 4 allele (APOE e4) could modify this beneficial effect. The aim of this systematic review was to analyze and synthetize the scientific evidence related to PA levels and CD risk in cognitively healthy APOE e4 carriers. Four electronic databases were analyzed. Only original articles with longitudinal study design were selected to analyze the relationship between PA and CD in APOE e4 carriers. Five studies were included in the systematic review. All studies except one stated that PA is a protective factor against CD in APOE e4 carriers. Moreover, partial support was found for the hypothesis that a greater amount and intensity of PA are more beneficial in CD prevention. The results support the idea that PA is a protective factor against CD in APOE e4 carriers. Nevertheless, it would be necessary to carry out further studies that would allow these findings to be contrasted.

scholarly journals Coffee and Green Tea Decoction Intake in the Tunisian Population According to Genetic Polymorphisms of Genes Involved in Habitual Caffeine Intake

2020 ◽  
Vol 20 (04) ◽  
Author(s):  
Sabri Denden
Keyword(s):  
Green Tea ◽  
Dietary Habits ◽  
Tunisian Population ◽  
Caffeine Intake ◽  
Human Populations ◽  
Caffeine Consumption ◽  
Coffee Intake ◽  
Caffeine Metabolism ◽  
The Relationship ◽  
Metabolism Gene

ABSTRACT The relationship between genetic variation and caffeinated beverages intake has been investigated in various human populations, but not among North Africans who have distinct caffeinated beverage dietary habits. Therefore, this study analysed the association between rs6968865 (AHR), rs382140 (NRCAM), rs9526558 (CAB39L), rs7754744 (PDSS2) and rs68157013 (TAS2R43) SNPs from previous GWASs on habitual caffeine consumption and caffeinated beverage intake in 568 healthy blood donors from the Tunisian population. The AHR caffeine metabolism gene SNP was associated with coffee intake but not with green tea decoction. However, the association of SNPs with caffeine metabolism (CAB39L and PDSS2), addiction to caffeine (NRCAM) and perceived caffeine bitterness (TAS2R43) genes was only observed or was stronger with the highest caffeine-containing beverage green tea decoction. The researchers further detected an opposite association of PDSS2 gene SNP with coffee and tea intake. The study provides additional data on caffeinated beverage intake genetics in a population with specific dietary habits

scholarly journals Relationship Between Pregnancy-Associated Malaria and Adverse Pregnancy Outcomes: a Systematic Review and Meta-Analysis

2019 ◽  
Vol 66 (3) ◽  
pp. 327-338 ◽  
Author(s):  
Julie M Thompson ◽  
Stephanie M Eick ◽  
Cody Dailey ◽  
Ariella P Dale ◽  
Mansi Mehta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcomes ◽  
Low Birthweight ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Inclusion Criteria ◽  
Search Terms ◽  
Study Characteristics ◽  
Adverse Pregnancy ◽  
The Relationship

Abstract Background Pregnancy-associated malaria (PAM) has been associated with adverse pregnancy outcomes like preterm birth (PTB) and low birthweight (LBW), which are among the leading causes of infant mortality globally. Rates of PTB and LBW are high in countries with a high burden of malaria. PAM may be a contributing factor to PTB and LBW, but is not well understood. Methods We conducted a systematic review and meta-analysis of studies examining the relationship between PAM and PTB or LBW using PubMed. The title and abstract of all studies were screened by two reviewers, and the full text of selected studies was reviewed to ensure they met inclusion criteria. Information regarding study characteristics and of PTB and LBW births among women with and without PAM was abstracted for included studies. Results Our search terms yielded 2237 articles, of which 18 met our final inclusion criteria. Eight studies examined associations between PAM and PTB, and 10 examined associations between PAM and LBW (population size ranging from 35 to 9956 women). The overall risk of LBW was 63% higher among women with PAM compared with women without PAM (95% CI = 1.48–1.80) and the risk of PTB was 23% higher among women with PAM compared with women without PAM (95% CI = 1.07–1.41). Conclusions These results indicate that infection with PAM is associated with PTB and LBW. Further understanding of the pathogenesis of disease and the immunologic changes that occur during pregnancy is essential for reducing the disproportional effects this disease has on this vulnerable population.

scholarly journals More evidence is needed. Iron, incident cognitive decline and dementia: a systematic review

2018 ◽  
Vol 9 (12) ◽  
pp. 241-256 ◽  
Author(s):  
Diane E. Hosking ◽  
Scott Ayton ◽  
Nigel Beckett ◽  
Andrew Booth ◽  
Ruth Peters
Keyword(s):  
Systematic Review ◽  
Cognitive Decline ◽  
Evidence Base ◽  
Eligibility Criteria ◽  
Longitudinal Outcomes ◽  
Dementia Incidence ◽  
Dietary Records ◽  
Study Characteristics ◽  
Quality And Outcomes

Background: Our aim was to systematically review the relationship between iron and incident cognitive decline or dementia from midlife onwards. Methods: Systematic review of eligible studies using Medline, Embase and PsycINFO® for the period from 1 January 1986 to 2 December 2016 (CRD42016023800), where study populations had a mean age of over 50 years and were free of cognitive impairment or dementia at baseline. Two authors independently extracted data according to eligibility criteria and assessed study characteristics, quality and outcomes. Disagreement was resolved by discussion. Results: A total of 1185 relevant records were identified with 12 full-text articles eligible for review. Six studies were excluded, leaving six texts to be included. Sample size ranged from 90 to 7173, with an average follow up of approximately 11.5 years. Baseline iron measures included brain iron ( n = 2), iron-related biomarkers in blood and plasma ( n = 2), and iron intake estimates from dietary records ( n = 2). Outcomes were dementia incidence ( n = 2) and longitudinal outcomes on neuropsychological tests ( n = 4). Bias was evident across studies in one or more of the following: recruitment, iron exposure, outcome assessments, potential confounders, missing data or attrition. Conclusions: Diversity across the small number of identified studies precludes conclusions regarding the role of iron in cognitive decline or dementia. Our review highlights substantial gaps in the evidence base and the need for more comprehensive, higher quality studies in this area.

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