Age-Related Hearing Loss, Neuropsychological Performance, and Incident Dementia in Older Adults

Journal of Alzheimer s Disease ◽

10.3233/jad-200908 ◽

2021 ◽

pp. 1-10

Author(s):

Katharine K. Brewster ◽

Mei-Chen Hu ◽

Melanie M. Wall ◽

Patrick J. Brown ◽

Sigal Zilcha-Mano ◽

...

Keyword(s):

Mean Difference ◽

Language Fluency ◽

Neurocognitive Performance ◽

Boston Naming Test ◽

Age Related ◽

Incident Dementia ◽

Neurocognitive Profile ◽

Age Related Hearing Loss ◽

Naming Test

Background: Age-related hearing loss (HL) has been associated with dementia, though the neurocognitive profile of individuals with HL is poorly understood. Objective: To characterize the neurocognitive profile of HL. Methods: N = 8,529 participants from the National Alzheimer’s Coordinating Center ≥60 years and free of cognitive impairment who were characterized as Untreated-, Treated-, or No HL. Outcomes included executive function (Trail Making Test [TMT] Part B), episodic memory (Immediate/Delayed Recall), language fluency (Vegetables, Boston Naming Test), and conversion to dementia. Regression models were fit to examine associations between HL and neurocognitive performance at baseline. Cox proportional hazards models examined the links between HL, neurocognitive scores, and development of dementia over follow-up. Results: At baseline, those with Untreated HL (versus No HL) had worse neurocognitive performance per standardized difference on executive function (TMT Part B [mean difference = 0.05 (95% CI 0.00, 0.10)]) and language fluency (Vegetables [mean difference = –0.07 (95% CI –0.14, –0.01)], Boston Naming Test [mean difference = –0.07 (95% CI –0.13, –0.01)]). No differences in these neurocognitive performance scores were demonstrated between Treated HL and No HL groups other than MMSE [mean difference = –0.06 (95% CI –0.12, 0.00)]. Through follow-up, executive dysfunction differed by hearing group (χ 2(2) = 46.08, p < 0.0001) and was present among 39.12% in No HL, 44.85% in Untreated HL, and 49.40% in Treated HL. Worse performance across all cognitive domains predicted incident dementia. Conclusion: The observed association between Untreated HL and lower cognitive ability that improved when hearing aids were worn may reflect an inability to hear the test instructions. Future studies using cognitive assessments validated for use in HL are needed to evaluate the neuropsychological profile of HL and identify individuals at risk for dementia.

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Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2021-319508 ◽

2021 ◽

pp. bjophthalmol-2021-319508

Author(s):

Xianwen Shang ◽

Zhuoting Zhu ◽

Yu Huang ◽

Xueli Zhang ◽

Wei Wang ◽

...

Keyword(s):

Heart Disease ◽

Age Related Macular Degeneration ◽

Hospital Inpatient ◽

Uk Biobank ◽

Age Related ◽

Incident Dementia ◽

Increased Risk ◽

The Uk ◽

Systemic Condition

AimsTo examine independent and interactive associations of ophthalmic and systemic conditions with incident dementia.MethodsOur analysis included 12 364 adults aged 55–73 years from the UK Biobank cohort. Participants were assessed between 2006 and 2010 at baseline and were followed up until the early of 2021. Incident dementia was ascertained using hospital inpatient, death records and self-reported data.ResultsOver 1 263 513 person-years of follow-up, 2304 cases of incident dementia were documented. The multivariable-adjusted HRs (95% CI) for dementia associated with age-related macular degeneration (AMD), cataract, diabetes-related eye disease (DRED) and glaucoma at baseline were 1.26 (1.05 to 1.52), 1.11 (1.00 to 1.24), 1.61 (1.30 to 2.00) and (1.07 (0.92 to 1.25), respectively. Diabetes, heart disease, stroke and depression at baseline were all associated with an increased risk of dementia. Of the combination of AMD and a systemic condition, AMD-diabetes was associated with the highest risk for incident dementia (HR (95% CI): 2.73 (1.79 to 4.17)). Individuals with cataract and a systemic condition were 1.19–2.29 times more likely to develop dementia compared with those without cataract and systemic conditions. The corresponding number for DRED and a systemic condition was 1.50–3.24. Diabetes, hypertension, heart disease, depression and stroke newly identified during follow-up mediated the association between cataract and incident dementia as well as the association between DRED and incident dementia.ConclusionsAMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.

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Noun and verb retrieval in healthy aging

Journal of the International Neuropsychological Society ◽

10.1017/s1355617702860040 ◽

2002 ◽

Vol 8 (6) ◽

pp. 764-770 ◽

Cited By ~ 41

Author(s):

ANNA J. MACKAY ◽

LISA TABOR CONNOR ◽

MARTIN L. ALBERT ◽

LORAINE K. OBLER

Keyword(s):

Healthy Aging ◽

Item Difficulty ◽

Age Groups ◽

Object Naming ◽

Boston Naming Test ◽

Age Related ◽

Action Naming ◽

New Findings ◽

Naming Test ◽

Name Retrieval

This study tests the hypothesis that retrieval of object and action names declines at different rates with age. Uncued and cued performance on the Boston Naming Test (BNT) and the Action Naming Test (ANT) were examined for 171 individuals from 50 to 88 years old. To control for differences in item difficulty, a subset of items from each of the two tests was selected for which uncued performance was equivalent in individuals in their 50s. With this matched set of items, differences in action and object naming were tested in the 60s and 70+ age groups. Although age-related decline in name retrieval was observed for both the BNT and the ANT subsets, no differences between object and action retrieval were found. Our results, thus, do not confirm previous studies reporting that object names and action names are differentially retrieved with aging. We discuss these new findings in relation to evidence of dissociations in object and action naming in brain-damaged individuals. (JINS, 2002, 8, 764–770.)

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Change in lexical retrieval skills in adulthood

The Mental Lexicon ◽

10.1075/ml.2.2.05gor ◽

2007 ◽

Vol 2 (2) ◽

pp. 215-238 ◽

Cited By ~ 38

Author(s):

Mira Goral ◽

Avron Spiro III ◽

Martin L. Albert ◽

Loraine K. Obler ◽

Lisa Tabor Connor

Keyword(s):

Cognitive Skills ◽

Lexical Processing ◽

Random Effect ◽

Lexical Retrieval ◽

Boston Naming Test ◽

Older Adulthood ◽

Age Related ◽

Action Naming ◽

Lexical Items ◽

Naming Test

We conducted multivariate random-effect analyses on longitudinal data from 238 adults, ranging in age from 30 to 94, who were tested on five lexical tests over a period of 20 years to examine (a) the relations between lemma and lexeme retrieval as manifested in different tests of lexical retrieval and (b) changes in lexical processing during older adulthood. This study documents differing profiles of age-related decline in lexical retrieval determined by task demand, gender, education, and underlying cognitive skills. The tasks that required retrieval of unique lexical items (Boston Naming Test and Action Naming Test) yielded significant age-related decline that became more rapid in older age, distinguishing them from tasks that allowed for the retrieval of various lexical items. Findings support a cascaded progression of lemma and lexeme retrieval during word production.

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The Relationship Between Cisplatin‐related and Age‐related Hearing Loss During an Extended Follow‐up

The Laryngoscope ◽

10.1002/lary.28543 ◽

2020 ◽

Vol 130 (9) ◽

Cited By ~ 1

Author(s):

Jakob Skalleberg ◽

Milada Cvancarova Småstuen ◽

Jan Oldenburg ◽

Terje Osnes ◽

Sophie D. Fosså ◽

...

Keyword(s):

Hearing Loss ◽

Age Related ◽

Age Related Hearing Loss ◽

The Relationship

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AGE-RELATED HEARING LOSS, LATE-LIFE DEPRESSION, AND RISK FOR INCIDENT DEMENTIA IN OLDER ADULTS

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2020.01.118 ◽

2020 ◽

Vol 28 (4) ◽

pp. S90-S93

Author(s):

Katharine Brewster ◽

Melanie Wall ◽

Alexandra Stein ◽

Sigal Zilcha-Mano ◽

Bret R. Rutherford

Keyword(s):

Older Adults ◽

Hearing Loss ◽

Late Life ◽

Late Life Depression ◽

Age Related ◽

Incident Dementia ◽

Age Related Hearing Loss

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Audiometric Age-Related Hearing Loss and Cognition in the Hispanic Community Health Study

Innovation in Aging ◽

10.1093/geroni/igab046.1327 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 344-344

Author(s):

Adam Brickman ◽

Adam Ciarleglio ◽

Nicole Schupf ◽

José Luchsinger ◽

Justin Golub

Keyword(s):

Hearing Loss ◽

Community Health ◽

Verbal Learning ◽

Small Samples ◽

Health Study ◽

Digit Symbol Substitution Test ◽

Neurocognitive Performance ◽

Age Related ◽

Hispanic Community ◽

Age Related Hearing Loss

Abstract Studies associating age-related hearing loss (HL) with cognition have been limited by non-Hispanic cohorts, small samples, or limited confounding control. We overcome these limitations in the largest study of formal, audiometric HL and cognition to date using the multicentered Hispanic Community Health Study (n=5,277, mean age=58.4 [SD=6.2]). The main exposure was audiometric HL. The main outcome was neurocognitive performance. Adjusting for demographics, hearing aid use, and cardiovascular disease, a 20-dB increase (one-category worsening) in HL was cross-sectionally associated with worse performance in multiple neurocognitive measures: -1.53 (95% CI = -2.11, -0.94) raw score point difference on Digit Symbol Substitution Test, -0.86 (-1.23, -0.49) on Word Frequency Test, -0.76 (-1.04, -0.47) on Spanish-English Verbal Learning Test (SEVLT) 3 trials, -0.45 (-0.60, -0.29) on SELVT recall, -0.07 (-0.12, -0.02) on Six-Item Screener. Because HL is common and potentially treatable, it should be investigated as a modifiable risk factor for neurocognitive decline/dementia.

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