Temporal Relationship between Depressive Symptoms and Cognitive Impairment: The Italian Longitudinal Study on Aging

2009 ◽  
Vol 17 (4) ◽  
pp. 899-911 ◽  
Author(s):  
Francesco Panza ◽  
Alessia D'Introno ◽  
Anna M. Colacicco ◽  
Cristiano Capurso ◽  
Angelo Del Parigi ◽  
...  
2007 ◽  
Vol 24 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Vincenzo Solfrizzi ◽  
Alessia D’Introno ◽  
Anna M. Colacicco ◽  
Cristiano Capurso ◽  
Angelo Del Parigi ◽  
...  

2020 ◽  
pp. 1-11
Author(s):  
Minyoung Shin

ABSTRACT Objectives: Geriatric depression complicates cognitive health in older adults. This study aims to investigate the impact of depressive symptoms on cognitive impairment in community-dwelling older adults, depending on whether cognitive dysfunction accompanied. Design: A community-based longitudinal cohort study. Setting: This study analyzed data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2018. Participants: Among 10,254 individuals who were registered in the KLoSA study, a total of 9119 subjects met the criteria, and 4547 subjects were included in the final analysis. The subjects were grouped into 4 categories based on depressive symptoms and cognitive dysfunction at baseline assessment: “normal control” (NC, n = 3341), “depression only” (Dep-only, n = 652), “cognitive dysfunction only” (CD-only, n = 393), and “depression with cognitive dysfunction” (Dep-CD, n = 161). Measurements: Cognitive impairment 10 years later was defined as K-MMSE scores below two percentile on demographically adjusted norms. Results: Ten-year survival, that is, not experiencing cognitive impairment, was 80 $$ \pm \,$$ 1% in NC group, 72 $$ \pm $$ 2% in Dep-only group, 52 $$ \pm $$ 3% in CD-only group, and 44 $$ \pm $$ 5% in Dep-CD group. The hazard ratio (HR) of the Dep-only group (HR = 1.18, 95% CI, 0.97–1.43, n.s.) did not differ from that of the NC group, but the HR of the Dep-CD group was significantly higher (HR = 2.85, 95% CI, 2.23–3.66, p < 0.001) than the NC group. When the Dep-CD group was compared to the CD-only group, the HR was 1.13 (95% CI, 0.85–1.49, n.s.), which indicates that it did not significantly differ from the CD-only group. Conclusions: Our findings suggest that depressive symptoms with cognitive dysfunction are associated with a higher risk of cognitive impairment. Furthermore, cognitive dysfunction occurring with depressive symptoms is as much a risk for cognitive impairment as is pure cognitive dysfunction. Thus, healthcare providers should pay close attention to the community-dwelling elderly when depressive symptoms occur with cognitive dysfunction.


2016 ◽  
Vol 54 (4) ◽  
pp. 1473-1482 ◽  
Author(s):  
Hyuma Makizako ◽  
Hiroyuki Shimada ◽  
Takehiko Doi ◽  
Kota Tsutsumimoto ◽  
Ryo Hotta ◽  
...  

2008 ◽  
Vol 27 (3, Suppl) ◽  
pp. S207-S215 ◽  
Author(s):  
Jeanne M. McCaffery ◽  
George D. Papandonatos ◽  
Cassandra Stanton ◽  
Elizabeth E. Lloyd-Richardson ◽  
Raymond Niaura

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