scholarly journals Use of Copper and Insulin-Resistance to Accelerate Cognitive Deficits and Synaptic Protein Loss in a Rat Aβ-Infusion Alzheimer's Disease Model

2008 ◽  
Vol 15 (4) ◽  
pp. 625-640 ◽  
Author(s):  
Aynun N. Begum ◽  
Fusheng Yang ◽  
Edmond Teng ◽  
Shuxin Hu ◽  
Mychica R. Jones ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Disease Model ◽  
Synaptic Protein ◽  
Protein Loss

scholarly journals A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer’s disease model

2014 ◽  
Vol 6 (3) ◽  
pp. 26 ◽  
Author(s):  
Shuang Wang ◽  
Yang Yu ◽  
Shuang Geng ◽  
Dongmei Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Disease Model ◽  
Brain Inflammation

Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer’s Disease Development in Mexico City Young Females

2021 ◽  
Author(s):  
Lilian Calderón-Garcidueñas ◽  
Suzanne M. de la Monte
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
High Risk ◽  
Mexico City ◽  
Cognitive Deficits ◽  
Central Nervous System Involvement ◽  
High Risk Group ◽  
Polycyclic Aromatic

Given the epidemiological trends of increasing Alzheimer’s disease (AD) and growing evidence that exposure and lifestyle factors contribute to AD risk and pathogenesis, attention should be paid to variables such as air pollution, in order to reduce rates of cognitive decline and dementia. Exposure to fine particulate matter (PM2.5) and ozone (O3) above the US EPA standards is associated with AD risk. Mexico City children experienced pre- and postnatal high exposures to PM2.5, O3, combustion-derived iron-rich nanoparticles, metals, polycyclic aromatic hydrocarbons, and endotoxins. Exposures are associated with early brain gene imbalance in oxidative stress, inflammation, innate and adaptive immune responses, along with epigenetic changes, accumulation of misfolded proteins, cognitive deficits, and brain structural and metabolic changes. The Apolipoprotein E (APOE) 4 allele, the most prevalent genetic risk for AD, plays a key role in the response to air pollution in young girls. APOE 4 heterozygous females with >75% to <94% BMI percentiles are at the highest risk of severe cognitive deficits (1.5–2 SD from average IQ). This review focused on the relationships between gender, BMI, systemic and neural inflammation, insulin resistance, hyperleptinemia, dyslipidemia, vascular risk factors, and central nervous system involvement in APOE4 urbanites exposed to PM2.5 and magnetite combustion-derived iron-rich nanoparticles that can reach the brain. APOE4 young female heterozygous carriers constitute a high-risk group for a fatal disease: AD. Multidisciplinary intervention strategies could be critical for prevention or amelioration of cognitive deficits and long-term AD progression in young individuals at high risk.

scholarly journals Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration

2013 ◽  
Vol 16 (6) ◽  
pp. 1351-1360 ◽  
Author(s):  
Marta Dobarro ◽  
Lourdes Orejana ◽  
Norberto Aguirre ◽  
Maria J. Ramírez
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Glycogen Synthase ◽  
Amyloid Β ◽  
Tau Phosphorylation ◽  
Object Recognition Test ◽  
Adrenergic Antagonist ◽  
Propranolol Treatment

Abstract Chronic exposure to glucocorticoids might result not only in insulin resistance or cognitive deficits, but it is also considered as a risk factor for pathologies such as Alzheimer's disease. Propranolol is a β-adrenergic antagonist commonly used in the treatment of hypertension or acute anxiety. The effects of propranolol (5 mg/kg) have been tested in a model of chronic corticosterone administration (100 µg/ml, 4 wk) in drinking water. Corticosterone administration led to cognitive impairment in the novel object recognition test that was reversed by propranolol. Increased levels of Aβ in the hippocampus of corticosterone-treated mice were counteracted by propranolol treatment, purportedly through an increased IDE expression. Chronic corticosterone treatment induced responses characteristic of insulin resistance, as increased peripheral insulin levels, decreased activation of the insulin receptor (pIR) and decreased associated intracellular pathways (pAkt). These effects might be related to a decreased c-Jun N terminal kinase 1 expression. Again, propranolol was able to counteract all corticosterone-induced effects. One of the main kinases involved in tau phosphorylation, glycogen synthase kinase 3β (GSK3β), which is inactivated by phosphorylation by pAkt, was found to be decreased after corticosterone and increased after propranolol treatment. Concomitant changes in pTau expression were found. Overall, these data further strengthen the potential of propranolol as a therapeutic agent for pathologies associated with the interaction glucocorticoids-insulin resistance and the development of relevant cellular processes for Alzheimer's disease.

Transplantation of GABAergic Interneuron Progenitor Attenuates Cognitive Deficits of Alzheimer’s Disease Model Mice

2020 ◽  
Vol 75 (1) ◽  
pp. 245-260
Author(s):  
Mei-Hong Lu ◽  
Xiu-Yun Zhao ◽  
De-En Xu ◽  
Ji-Bo Chen ◽  
Wen-Li Ji ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Disease Model ◽  
Gabaergic Interneuron

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

2014 ◽  
Vol 68 ◽  
pp. 126-136 ◽  
Author(s):  
Brice Ongali ◽  
Nektaria Nicolakakis ◽  
Xin-Kang Tong ◽  
Tahar Aboulkassim ◽  
Panayiota Papadopoulos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Angiotensin Ii ◽  
Cognitive Deficits ◽  
Disease Model ◽  
Receptor Blocker

Reduced expression of Na + /Ca 2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice

2018 ◽  
Vol 131 ◽  
pp. 291-303 ◽  
Author(s):  
Shigeki Moriguchi ◽  
Satomi Kita ◽  
Masahiro Fukaya ◽  
Makoto Osanai ◽  
Ryo Inagaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Disease Model
Sign in / Sign up

Export Citation Format

Share Document