scholarly journals Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus

2020 ◽  
Vol 78 (1) ◽  
pp. 195-205
Author(s):  
Yejin Yun ◽  
Sang-Yeon Lee ◽  
Won Hoon Choi ◽  
Jong-Chan Park ◽  
Dong Han Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
High Frequency ◽  
Disease Model ◽  
Proteasome Activity ◽  
Chronic Tinnitus ◽  
Aged Patients ◽  
Non Invasive ◽  
Plasma Enzymes ◽  
New Perspective

Background: Although the existence of proteasomes in human blood, termed circulating proteasomes (c-proteasomes), has been reported previously, their origin and pathophysiological functions remain largely unknown. Objective: Given that c-proteasome activity was significantly reduced in Alzheimer’s disease model mice and relatively high frequency of mild cognitive impairment (MCI) is accompanied by chronic tinnitus in aged patients, we examined whether c-proteasome activity in human plasma was associated with cognitive function in patients with chronic tinnitus. Methods: c-Proteasome activity in the plasma of tinnitus patients (N = 55) was measured with fluorogenic reporter substrate, suc-LLVY-AMC. To assess MCI, the Montreal Cognitive Assessment was conducted with a cut-off score of 22/23. All patients underwent audiological and psychoacoustic analyses. Levels of c-proteasomes, Aβ42, and Aβ40 were measured using ELISA, and their association with c-proteasome activity was evaluated. Results: The activity of circulating proteasomes was significantly lower in patients with chronic tinnitus and MCI (p = 0.042), whereas activities of other plasma enzymes showed little correlation. In addition, c-proteasome activity was negatively associated with the level of plasma Aβ and was directly dependent on its own concentration in the plasma of patients with chronic tinnitus. Conclusion: Our current work provides a new perspective for understanding the potential relationship between circulating proteasomes in the plasma and cognitive dysfunction, suggesting a novel, non-invasive biomarker in the context of MCI diagnosis.

scholarly journals Neurocognition of Aged Patients With Chronic Tinnitus: Focus on Mild Cognitive Impairment

2020 ◽  
Vol 13 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Sang-Yeon Lee ◽  
Jun Young Lee ◽  
·Sang-Yoon Han ◽  
Yuju Seo ◽  
Ye Ji Shim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Underlying Mechanism ◽  
Multivariate Regression Analysis ◽  
Chronic Tinnitus ◽  
Initial Assessment ◽  
Aged Patients ◽  
Tinnitus Severity ◽  
Patient Health ◽  
The Impact

Objectives. To investigate the neurocognition of aged patients with chronic tinnitus and reveal the possible association between tinnitus severity and cognitive function, with attention to mild cognitive impairment (MCI).Methods. Fifty-eight elderly patients (≥65 years old) with chronic tinnitus (≥6 months) were prospectively enrolled in this study. All patients assessed the neurocognitive batteries including the Korean version of the patient health questionnaire-9 (K-PHQ-9), the Lawton instrumental activities of daily living scale (K-IADL), and the Montreal cognitive assessment (MoCA-K). After initial evaluation to exclude moderate or severe cognitive impairment by a psychiatrist, the patients were classified into two groups: MCI and non-MCI, according to the MoCA-K scores (cutoff value, 22/23). All patients underwent audiological examinations including psychoacoustic tests of tinnitus.Results. Of 58 patients, 10 (17.2%) met the MCI criteria. The tinnitus handicap inventory (THI) score in the MCI group was significantly higher than that in the non-MCI group. Based on multivariate regression analysis, a significant association between tinnitus severity and MoCA-K score was also detected. Specifically, bothersome tinnitus (THI score ≥30) was closely linked to the presence of MCI. Meanwhile, the impact of MCI on both K-PHQ-9 and K-IADL scores was not evident in patients with chronic tinnitus.Conclusion. Tinnitus severity appears to be a potential independent determinant for predicting the MCI, suggesting the underlying mechanism between chronic tinnitus and cognitive deficit. Given that MCI highly links to dementia, the evaluation of cognitive functions in aged patients with chronic tinnitus need to be considered at the initial assessment of tinnitus.

scholarly journals Virtual Reality Meets Non-invasive Brain Stimulation: Integrating Two Methods for Cognitive Rehabilitation of Mild Cognitive Impairment

2020 ◽  
Vol 11 ◽  
Author(s):  
Valentina Mancuso ◽  
Chiara Stramba-Badiale ◽  
Silvia Cavedoni ◽  
Elisa Pedroli ◽  
Pietro Cipresso ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Stimulation ◽  
Cognitive Rehabilitation ◽  
Non Invasive

scholarly journals Corneal nerve and brain imaging in mild cognitive impairment and dementia: A cross-sectional study

2020 ◽  
Author(s):  
Eiman Al-Janahi ◽  
Georgios Ponirakis ◽  
Hanadi Al Hamad ◽  
Surjith Vattoth ◽  
Ahmed Elsotouhy ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Roc Curve ◽  
Statistical Tests ◽  
Imaging Biomarker ◽  
Kappa Statistics ◽  
Non Invasive ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve

Abstract Background: Visual rating of medial temporal lobe atrophy (MTA) is an accepted biomarker of Alzheimer’s disease. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging biomarker of neurodegeneration. We sought to determine the diagnostic accuracy of CCM to distinguish mild cognitive impairment (MCI) and dementia from no cognitive impairment (NCI) in relation to MTA rating.Methods: Subjects aged 60-85 with NCI, MCI and dementia were recruited from the geriatric and memory clinic in Rumailah Hospital, Doha, Qatar between 18/09/16 and 31/07/19. The diagnosis of MCI and dementia were based on the International Classification of Diseases (ICD-10) criteria. Subjects underwent cognitive screening using the Montreal Cognitive Assessment (MoCA), CCM and MTA rating on MRI. Statistical tests used were ANOVA with Bonferroni’s post hoc test, kappa statistics and receiver operating characteristic (ROC) curve analysis. A two-tailed P value of ≤0.05 was considered significant.Results: 182 subjects with NCI (n=36), MCI (n=80) and dementia (n=66), including AD (n=19, 28.8%), VaD (n=13, 19.7%) and combined AD (n=34, 51.5%) were studied. CCM showed a progressive reduction in corneal nerve fiber density (CNFD, fibers/mm2) (32.0±7.5 vs 24.5±9.6 vs 20.8±9.3, p<0.0001), branch density (CNBD, branches/mm2) (90.9±46.5 vs 59.3±35.7 vs 53.9±38.7, p<0.0001), and fiber length (CNFL, mm/mm2) (22.9±6.1 vs 17.2±6.5 vs 15.8±7.4, p<0.0001), in subjects with MCI and dementia compared to NCI. The MTA rating in the dementia group was significantly higher compared with the NCI and MCI group in the right (1.9±1.0 vs 0.5±0.6 and 0.6±0.8, p<0.0001) and left (2.1±1.1 vs 0.6±0.7 and 0.8±0.8, p<0.0001) hemispheres. The area under the ROC curve (95% CI) for the diagnostic accuracy of CNFD, CNBD, CNFL vs MTA-right and -left for MCI was 78% (67-90%), 82% (72-92%), 86% (77-95%) vs 53% (36-69%) and 40% (25-55%), respectively, and for dementia it was 85% (76-94%), 84% (75-93%), 85% (76-94%) vs 86% (76-96%) and 82% (72-92%), respectively.Conclusions: The diagnostic accuracy of CCM, a non-invasive ophthalmic biomarker of neurodegeneration was high and comparable with MTA rating for dementia and superior to MTA rating for MCI.

scholarly journals Cognitive impairment is a common comorbidity in COVID-19 deceased patients. A hospital-based retrospective cohort study

2020 ◽  
Author(s):  
Paloma Martín-Jiménez ◽  
Mariana I. Muñoz-García ◽  
David Seoane ◽  
Lucas Roca-Rodríguez ◽  
Ana García-Reyne ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Palliative Care ◽  
Cohort Study ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Symptom Onset ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Invasive Mechanical Ventilation ◽  
Non Invasive

ABSTRACTIntroductionLittle is known about the relation of cognitive impairment (CI) to COVID-19 mortality. Here, we analyse the frequency of CI in deceased COVID-19 patients.MethodsWe included 477 adult cases that died after admission from March 1 to March 31, 2020: 281 with confirmed COVID-19, 58 probable COVID-19, and 138 who died of other causes.ResultsThe number of comorbidities was high in the confirmed COVID-19, and CI was common (30%: 21.1% dementia; 8.9% mild cognitive impairment). Subjects with CI were older, more lived in nursing homes and had shorter times from symptom onset to death than those without CI. COVID-19 patients with CI were rarely admitted to the ICU and fewer received non-invasive mechanical ventilation, but palliative care was provided more often.ConclusionsDementia is a frequent comorbidity in COVID-19 deceased patients. The burden of COVID-19 in the dementia community will be high.

scholarly journals Corneal Nerve and Brain Imaging in Mild Cognitive Impairment and Dementia

2020 ◽  
Vol 77 (4) ◽  
pp. 1533-1543
Author(s):  
Eiman Al-Janahi ◽  
Georgios Ponirakis ◽  
Hanadi Al Hamad ◽  
Surjith Vattoth ◽  
Ahmed Elsotouhy ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Medial Temporal Lobe Atrophy ◽  
Non Invasive ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve ◽  
Lobe Atrophy

Background: Visual rating of medial temporal lobe atrophy (MTA) is an accepted structural neuroimaging marker of Alzheimer’s disease. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic technique that detects neuronal loss in peripheral and central neurodegenerative disorders. Objective: To determine the diagnostic accuracy of CCM for mild cognitive impairment (MCI) and dementia compared to medial temporal lobe atrophy (MTA) rating on MRI. Methods: Subjects aged 60–85 with no cognitive impairment (NCI), MCI, and dementia based on the ICD-10 criteria were recruited. Subjects underwent cognitive screening, CCM, and MTA rating on MRI. Results: 182 subjects with NCI (n = 36), MCI (n = 80), and dementia (n = 66), including AD (n = 19, 28.8%), VaD (n = 13, 19.7%), and mixed AD (n = 34, 51.5%) were studied. CCM showed a progressive reduction in corneal nerve fiber density (CNFD, fibers/mm2) (32.0±7.5 versus 24.5±9.6 and 20.8±9.3, p < 0.0001), branch density (CNBD, branches/mm2) (90.9±46.5 versus 59.3±35.7 and 53.9±38.7, p < 0.0001), and fiber length (CNFL, mm/mm2) (22.9±6.1 versus 17.2±6.5 and 15.8±7.4, p < 0.0001) in subjects with MCI and dementia compared to NCI. The area under the ROC curve (95% CI) for the diagnostic accuracy of CNFD, CNBD, CNFL compared to MTA-right and MTA-left for MCI was 78% (67–90%), 82% (72–92%), 86% (77–95%) versus 53% (36–69%) and 40% (25–55%), respectively, and for dementia it was 85% (76–94%), 84% (75–93%), 85% (76–94%) versus 86% (76–96%) and 82% (72–92%), respectively. Conclusion: The diagnostic accuracy of CCM, a non-invasive ophthalmic biomarker of neurodegeneration, was high and comparable with MTA rating for dementia but was superior to MTA rating for MCI.

scholarly journals A non-invasive hidden-goal test for spatial orientation deficit detection in subjects with suspected mild cognitive impairment

2020 ◽  
Vol 332 ◽  
pp. 108547 ◽  
Author(s):  
Danira Bažadona ◽  
Ivan Fabek ◽  
Mirjana Babić Leko ◽  
Mihaela Bobić Rasonja ◽  
Dubravka Kalinić ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Spatial Orientation ◽  
Non Invasive

scholarly journals Effects of Chronic Tinnitus on Metabolic and Structural Changes in Subjects With Mild Cognitive Impairment

2020 ◽  
Vol 12 ◽  
Author(s):  
Sang-Yeon Lee ◽  
Heejung Kim ◽  
Jun Young Lee ◽  
Ju Hye Kim ◽  
Dong Young Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Structural Changes ◽  
Chronic Tinnitus
Sign in / Sign up

Export Citation Format

Share Document