Cholesterol Secoaldehyde, An Ozonation Product of Cholesterol, Induces Amyloid Aggregation and Apoptosis in Murine GT1-7 Hypothalamic Neurons

2007 ◽  
Vol 11 (3) ◽  
pp. 261-274 ◽  
Author(s):  
K. Sathishkumar ◽  
Xiaochun Xi ◽  
Roy Martin ◽  
Rao M. Uppu
Keyword(s):  
Amyloid Aggregation ◽  
Hypothalamic Neurons ◽  
Ozonation Product

Role of the Structural Characteristics of Dendrimers in the Manifestation of the Antiamyloid Properties

INEOS OPEN ◽  
2020 ◽  
Vol 3 ◽  
Author(s):  
S. A. Sorokina ◽  
◽  
Yu. Yu. Stroilova ◽  
V. I. Muronets ◽  
Z. B. Shifrina ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Structural Characteristics ◽  
Short Review ◽  
External Factors ◽  
Amyloid Aggregation ◽  
Amyloid Proteins ◽  
Molecular Parameters ◽  
Amyloid Aggregates ◽  
Aggregation Processes

Among the compounds able to efficiently inhibit the amyloid aggregation of proteins and decompose the amyloid aggregates that cause neurodegenerative diseases, of particular interest are dendrimers, which represent individual macromolecules with the hypercrosslinked architectures and given molecular parameters. This short review outlines the peculiarities of the antiamyloid activity of dendrimers and discusses the effect of dendrimer structures and external factors on their antiamyloid properties. The potential of application of dendrimers in further investigations on the aggregation processes of amyloid proteins as the compounds that exhibit the remarkable antiamyloid activity is evaluated.

Synthetic and secretory activity of oxytocin-producing hypothalamic neurons

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S111
Author(s):  
G. F. JIRIKOWSKI ◽  
F. ORTIGAO ◽  
CH. PILGRIM ◽  
H. SELIGER
Keyword(s):  
Secretory Activity ◽  
Hypothalamic Neurons

Origin of secretory activity of magnocellular hypothalamic neurons in vivo

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S231-S232
Author(s):  
M. KLEMPT ◽  
F. ELLENDORFF ◽  
R. GROSSMANN
Keyword(s):  
Secretory Activity ◽  
Hypothalamic Neurons

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

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