scholarly journals Patterns of Regional Cerebral Blood Flow as a Function of Obesity in Adults

2020 ◽  
Vol 77 (3) ◽  
pp. 1331-1337
Author(s):  
Daniel G. Amen ◽  
Joseph Wu ◽  
Noble George ◽  
Andrew Newberg
Keyword(s):  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Performance Test ◽  
Continuous Performance Test ◽  
Brain Regions ◽  
Normal Weight ◽  
Continuous Performance ◽  
Regional Cerebral Blood ◽  
Perfusion Abnormality ◽  
Brain Scans

Background: While obesity has been shown to be a risk factor for Alzheimer’s disease, the potential mechanisms underlying this risk may be clarified with better understanding of underlying physiology in obese persons. Objective: To identify patterns of cerebral perfusion abnormality in adults as a function of body mass index (BMI) defined weight categories, including overweight or obese status. Methods: A large psychiatric cohort of 35,442 brain scans across 17,721 adults (mean age 40.8±16.2 years, range 18–94 years) were imaged with SPECT during baseline and concentration scans, the latter done after each participant completed the Connors Continuous Performance Test II. ANOVA was done to identify patterns of perfusion abnormality in this cohort across BMI designations of underweight (BMI < 18.5), normal weight (BMI = 18.5 to 24.9), overweight (BMI 24.9 to 29.9), obesity (BMI≥30), and morbid obesity (BMI≥40). This analysis was done for 128 brain regions quantifying SPECT perfusion using the automated anatomical labeling (AAL) atlas. Results: Across adulthood, higher BMI correlated with decreased perfusion on both resting and concentration brain SPECT scans. These are seen in virtually all brain regions, including those influenced by AD pathology such as the hippocampus. Conclusion: Greater BMI is associated with cerebral perfusion decreases in both resting and concentration SPECT scans across adulthood.

scholarly journals Do Overweight People Have Worse Cognitive Flexibility? Cues-Triggered Food Craving May Have a Greater Impact

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 240
Author(s):  
Shiqing Song ◽  
Qingqing Li ◽  
Yan Jiang ◽  
Yong Liu ◽  
Aidi Xu ◽  
...  
Keyword(s):  
Cognitive Flexibility ◽  
Performance Test ◽  
Continuous Performance Test ◽  
Brain Regions ◽  
Normal Weight ◽  
Food Craving ◽  
Control Mechanisms ◽  
Reactive Control ◽  
Food Cravings ◽  
Overweight People

Background: Overweight people have been revealed to have poor cognitive flexibility. Cognitive flexibility reflects proactive and reactive control abilities. However, the impairment had not been explicitly positioned at the cognitive stage. Therefore, this study provides increased support for impairment of cognitive flexibility due to overweight. Method: The study included 34 overweight and 35 normal-weight participants. They were required to complete the food and flower target AX-continuous performance test (AX–CPT), including the resting-state fMRI and cue-triggered food craving subscales. We compared the performance difference between the two tasks. Furthermore, we investigated whether the cue-triggered food cravings and the corresponding brain regions mediated the effect of overweight on the two control mechanisms. Result: Significant differences were found only in the food target AX-CPT task, where overweight participants performed worse. Cue-triggered food cravings mediated this relationship. Additionally, we found that the brain regions associated with cue-triggered food cravings (bilateral SFG) can completely mediate the relationship between BMI and the z-value of the fat mass index and sensitivity to proactive control. Conclusion: In the food target task, overweight participants performed worse in both control mechanisms. Moreover, we also revealed the potential mechanism by which being overweight might affect the two control mechanisms through cue-triggered food cravings.

Contingent Negative Variation (CNV) bei Kindern mit hyperkinetischem Syndrom - eine experimentelle Untersuchung mittels des Continuous Performance Test (CPT)

2000 ◽  
Vol 28 (4) ◽  
pp. 239-246 ◽  
Author(s):  
K. Hennighausen ◽  
G. Schulte-Körne ◽  
A. Warnke ◽  
H. Remschmidt
Keyword(s):  
Contingent Negative Variation ◽  
Performance Test ◽  
Continuous Performance Test ◽  
Continuous Performance ◽  
Experimentelle Untersuchung

Zusammenfassung Fragestellung: Gibt es neurophysiologische Korrelate der Aufmerksamkeitsstörung beim hyperkinetischen Syndrom (HKS) und welche Bedeutung haben diese für die Ätiologie der Störung. Methodik: Selektive Aufmerksamkeitsprozesse wurden anhand des zweistufigen Continuous Performance Test (CPT) bei 18 Jungen mit hyperkinetischem Syndrom (HKS) untersucht und mit einer nach dem Alter parallelisierten Kontrollgruppe von 21 Jungen verglichen. Die Altersspanne der Stichprobe betrug 6 bis 12 Jahre. Parallel dazu wurden ereigniskorrelierte Potentiale (EKP) während des Tests an den Elektrodenpositionen Fz, Cz, Pz und Oz mit Referenz zu verbundenen Ohren abgeleitet. Ergebnisse: Im EKP nach dem präparatorischen Stimulus konnten zwei Komponenten der Contingent Negative Variation (CNV) mit unterschiedlicher topographischer Verteilung identifiziert werden (CNV-1: 600 bis 1100 ms und CNV-2: 1000 bis 1500 ms nach Stimulus). Die Stichproben unterschieden sich nicht auf der Verhaltensebene (Fehlerrate und Reaktionszeit). Signifikante Gruppenunterschiede ergaben sich hinsichtlich der Topographie der beiden CNV-Komponenten. Kinder mit HKS zeigten im Vergleich zu Kontrollkindern eine signifikant niedrigere CNV-1 über der frontalen und eine Tendenz zu stärkerer Negativierung (CNV-1 und CNV-2) über der occipitalen Elektrode. Schlussfolgerungen: Die Ergebnisse unterstützen die Hypothese einer Unterfunktion frontaler inhibitorischer Prozesse bei Kindern mit HKS.

Comparing the Mathematics Continuous Performance Test With Other Measures of Tests of Attention

2016 ◽  
Vol 32 (4) ◽  
pp. 291-297 ◽  
Author(s):  
Dubi Lufi ◽  
Shachar Pan
Keyword(s):  
Performance Test ◽  
Continuous Performance Test ◽  
Clinical Population ◽  
Control Group ◽  
Continuous Performance ◽  
Adhd Assessment ◽  
Research Reporting ◽  
Hyperactivity Disorder ◽  
Continuous Performance Tests ◽  
Better Than

Abstract. Several studies have shown that Continuous Performance Tests (CPT) can diagnose Attention Deficit Hyperactivity Disorder (ADHD) better than other tests. Research reporting comparisons of two or more CPT-type tests is scarce. The purpose of the study was to compare the Mathematics Continuous Performance Test (MATH-CPT) with another CPT-type test (CPT II) and a questionnaire (the Brown Scale). The comparison was carried out by looking at correlations among subscales and checking the precision of detecting ADHD. Ninety-five high school and college students participated in the study, 41 with ADHD were the research group and 54 were the control group. The participants performed the two tests and answered the questionnaire. The results showed that the MATH-CPT correctly identified 74.50% of the participants of both groups as compared to the 71.60% of the CPT II. Correlations between the two CPT-type tests were moderate; however, they were similar to correlations found in other studies comparing similar tools. The MATH-CPT, final attention formula, showed significant correlations with the Brown scales, while the CPT II, confidence index associated with ADHD assessment, showed nonsignificant correlations with the questionnaire. The study indicated that MATH-CPT can be used with a clinical population of ADHD and for research purposes.

prisoners use an inflexible strategy in a continuous performance test: A replication

1997 ◽  
Vol 23 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Arne Dalteg ◽  
Kirsten Rasmussen ◽  
Jimmy Jensen ◽  
Bengt Persson ◽  
May Lindgren ◽  
...  
Keyword(s):  
Performance Test ◽  
Continuous Performance Test ◽  
Continuous Performance

Deficits on the continuous performance test within the schizophrenia spectrum and the mediating effects of family history of schizophrenia.

2006 ◽  
Vol 115 (4) ◽  
pp. 771-778 ◽  
Author(s):  
Matthew T. Avila ◽  
Olalla Robles ◽  
L. Elliot Hong ◽  
Theresa A. Blaxton ◽  
Carol S. Myers ◽  
...  
Keyword(s):  
Family History ◽  
Performance Test ◽  
Continuous Performance Test ◽  
Continuous Performance ◽  
Mediating Effects ◽  
Schizophrenia Spectrum ◽  
History Of
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