Dendrobium nobile Lindl Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity

2020 ◽  
pp. 1-13 ◽  
Author(s):  
Ling-Li Lv ◽  
Bo Liu ◽  
Jing Liu ◽  
Li-Sheng Li ◽  
Feng Jin ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Amyloid Β ◽  
Dendrobium Nobile ◽  
Dendrobium Nobile Lindl ◽  
Samp8 Mice ◽  
Autophagy Activity

scholarly journals Cardioprotective effects of Ginsenoside compound-Mc1 and Dendrobium Nobile Lindl against myocardial infarction in an aged rat model: Involvement of TLR4/NF-κB signaling pathway

2021 ◽  
Vol 19 ◽  
pp. 205873922110005
Author(s):  
Yongle Sun ◽  
Jing Geng ◽  
Deyu Wang
Keyword(s):  
Myocardial Infarction ◽  
Combination Therapy ◽  
Infarct Size ◽  
Signaling Pathway ◽  
Left Ventricular ◽  
Male Rats ◽  
Dendrobium Nobile ◽  
Tnf Α ◽  
Cardioprotective Effects ◽  
Dendrobium Nobile Lindl

Aging is the crucial co-morbidity that prevents the full cardioprotection against myocardial ischemia/reperfusion (I/R) injury. Combination therapy as a promising strategy may overcome this clinical problem. This study aimed to investigate the cardioprotective effects of Ginsenoside compound-Mc1 (GMc1) and Dendrobium Nobile Lindl (DNL) in myocardial I/R injury and explore the involvement of the TLR4/NF-κB signaling pathway in aged rats. In vivo I/R injury and myocardial infarction was established by temporary coronary ligation in 22–24 months’ old Sprague Dawley male rats. GMc1 (10 mg/kg) and DNL (80 mg/kg) were administered intraperitoneally for 4 weeks and orally for 14 days, respectively, before I/R injury. Infarct size was measured through triphenyl-tetrazolium-chloride staining. ELISA assay was conducted to quantify the levels of cardiotroponin, and myocardial content of TNF-α and glutathione. Western blotting was employed to detect the expression of TLR4/MyD88/NF-κB proteins. GMc1 and DNL significantly reduced the infarct size to a similar extent ( p < 0.05) but their combined effect was greater than individual ones ( p < 0.01). Combination therapy significantly restored the left ventricular end-diastolic and developed pressures at the end of reperfusion as compared with the untreated group ( p < 0.01). Although the GMc1 and DNL reduced the levels of inflammatory cytokine TNF-α and increased the contents of antioxidant glutathione significantly, their individual effects on the reduction of protein expression of TLR4/MyD88/NF-κB pathway were not consistent. However, their combination could significantly reduce all parameters of this inflammatory pathway as compared to untreated I/R rats ( p < 0.001). Therefore, the combined treatment with GMc1 and DNL increased the potency of each intervention in protecting the aged hearts against I/R injury. Reduction in the activity of the TLR4/MyD88/NF-κB signaling pathway and subsequent modulation of the activity of inflammatory cytokines and endogenous antioxidants play an important role in this cardioprotection.

scholarly journals Dendrobium nobile Lindl. alkaloids alleviate Mn-induced neurotoxicity via PINK1/Parkin-mediated mitophagy in PC12 cells

2021 ◽  
Vol 26 ◽  
pp. 100877
Author(s):  
Xiaolong Fu ◽  
Shu Chen ◽  
Xueting Wang ◽  
Yanhua Shen ◽  
Ru Zeng ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Dendrobium Nobile ◽  
Dendrobium Nobile Lindl

scholarly journals Effects of the Endophytic Fungus MF23 on Dendrobium nobile Lindl. in an Artificial Primary Environment

ACS Omega ◽  
2021 ◽  
Author(s):  
Xingyue Chen ◽  
Qing Li ◽  
Xiaolin Xu ◽  
Gang Ding ◽  
Shunxing Guo ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Dendrobium Nobile ◽  
Dendrobium Nobile Lindl

scholarly journals Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse

2020 ◽  
Vol 154 ◽  
pp. 35-44 ◽  
Author(s):  
Keiko Ishida ◽  
Masaki Yamamoto ◽  
Kensuke Misawa ◽  
Hitomi Nishimura ◽  
Koichi Misawa ◽  
...  
Keyword(s):  
Transgenic Mouse ◽  
Cognitive Dysfunction ◽  
Amyloid Β

scholarly journals Alongamento de plantas de Dendrobium nobile Lindl. com pulverização de ácido giberélico

2007 ◽  
Vol 31 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Mívia Rosa de Medeiros Vichiato ◽  
Marcelo Vichiato ◽  
Daniel Melo de Castro ◽  
Leonardo Ferreira Dutra ◽  
Moacir Pasqual
Keyword(s):  
Dendrobium Nobile ◽  
Dendrobium Nobile Lindl

Dendrobium nobile Lindl. (olho-de-boneca) é uma das orquídeas mais populares do Brasil, ocupando posição de destaque no mercado de plantas de corte e de vaso. Entretanto, o desenvolvimento muito lento da família Orchidaceae tem contribuído para o elevado valor unitário de suas plantas, sendo necessárias técnicas que promovam a obtenção mais rápida de plantas comercializáveis. Objetivando avaliar o efeito do ácido giberélico no alongamento de plantas de D. nobile, foi realizado experimento em delineamento inteiramente casualizado com cinco concentrações de GA3 (0, 50, 100, 200 e 400 mg.L-1) e treze repetições. Efetuaram-se quatro pulverizações com soluções de ácido giberélico a intervalos quinzenais e noventa dias após início dos tratamentos, avaliaram-se as seguintes características: altura e diâmetro do pseudobulbo, número de folhas, largura e comprimento das folhas. A aplicação do GA3 promoveu, em comparação às plantas testemunhas, incrementos de 64,08% em altura e 44,27% no comprimento das folhas e decréscimos de 50% no diâmetro do pseudobulbo e 56,09% na largura das folhas. Não houve diferença entre as concentrações de GA3 testadas. Portanto, o ácido giberélico nas concentrações de 50 a 400 mg.L-1 é igualmente eficiente no alongamento de plantas D. nobile.

scholarly journals Clinical study of Dendrobium Nobile Lindl intervention on patients with metabolic syndrome

Medicine ◽  
2021 ◽  
Vol 100 (12) ◽  
pp. e24574
Author(s):  
Xiaoyan Zhang ◽  
Miao Wang ◽  
Chengbo Zhang ◽  
Zhidong Liu ◽  
Shigao Zhou
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Study ◽  
Dendrobium Nobile ◽  
Dendrobium Nobile Lindl

Structural analysis of a rhamnoarabinogalactan from the stems of Dendrobium nobile Lindl

2010 ◽  
Vol 122 (3) ◽  
pp. 572-576 ◽  
Author(s):  
Jun-Hui Wang ◽  
Jian-Ping Luo ◽  
Xue-Fei Yang ◽  
Xue-Qiang Zha
Keyword(s):  
Structural Analysis ◽  
Dendrobium Nobile ◽  
Dendrobium Nobile Lindl
Sign in / Sign up

Export Citation Format

Share Document