scholarly journals Supplementation with Matured Hop Bitter Acids Improves Cognitive Performance and Mood State in Healthy Older Adults with Subjective Cognitive Decline

2020 ◽  
Vol 76 (1) ◽  
pp. 387-398 ◽  
Author(s):  
Takafumi Fukuda ◽  
Tohru Ohnuma ◽  
Kuniaki Obara ◽  
Sumio Kondo ◽  
Heii Arai ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Mood State ◽  
Subjective Cognitive Decline ◽  
Healthy Older Adults ◽  
Bitter Acids

Characteristics of Healthy Older Adults that Influence Self-rated Cognitive Function

2017 ◽  
Vol 24 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Bryce P. Mulligan ◽  
Colette M. Smart ◽  
Sidney J. Segalowitz ◽  
Stuart W.S. MacDonald
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Healthy Aging ◽  
Memory Performance ◽  
Short Term ◽  
Healthy Older Adults ◽  
Subjective Cognitive Function

AbstractObjectives: We sought to clarify the nature of self-reported cognitive function among healthy older adults by considering the short-term, within-person association (coupling) of subjective cognitive function with objective cognitive performance. We expected this within-person coupling to differ between persons as a function of self-perceived global cognitive decline and depression, anxiety, or neuroticism. Methods: This was an intensive measurement (short-term longitudinal) study of 29 older adult volunteers between the ages of 65 and 80 years without an existing diagnosis of dementia or mild cognitive impairment. Baseline assessment included neuropsychological testing and self-reported depression, anxiety, and neuroticism, as well as self- and informant-reported cognitive decline (relative to 10 years previously). Intensive within-person measurement occasions included subjective ratings of cognitive function paired with performance on a computerized working memory (n-back) task; each participant attended four or five assessments separated by intervals of at least one day. Statistical analysis was comprised of multilevel linear regression. Results: Comparison of models suggested that both neuroticism and self-rated cognitive decline explained unique variance in the within-person, across-occasion coupling of subjective cognitive function with objective working memory performance. Conclusions: Self-ratings of cognition may accurately reflect day-to-day variations in objective cognitive performance among older adults, especially for individuals lower in neuroticism and higher in self-reported cognitive decline. Clinicians should consider these individual differences when determining the validity of complaints about perceived cognitive declines in the context of otherwise healthy aging. (JINS, 2018, 24, 57–66)

Effects of Morning Blue-Green 500 nm Light Therapy on Cognition and Biomarkers in Middle-Aged and Older Adults with Subjective Cognitive Decline and Mild Cognitive Impairment: Study Protocol for a Randomized Controlled Trial

2021 ◽  
pp. 1-16
Author(s):  
Ziqi Wang ◽  
Yige Zhang ◽  
Li Dong ◽  
Zihao Zheng ◽  
Dayong Zhong ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Controlled Trial ◽  
Light Therapy ◽  
Physiological Parameters ◽  
Subjective Cognitive Decline ◽  
Middle Aged

Background: Given that there is no specific drug to treat Alzheimer’s disease, non-pharmacologic interventions in people with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are one of the most important treatment strategies. Objective: To clarify the efficacy of blue-green (500 nm) light therapy on sleep, mood, and physiological parameters in patients with SCD and aMCI is an interesting avenue to explore. Methods: This is a monocentric, randomized, and controlled trial that will last for 4 weeks. We will recruit 150 individuals aged 45 years or older from memory clinics and divide them into 5 groups: SCD treatment (n = 30), SCD control (n = 30), aMCI treatment (n = 30), aMCI control (n = 30), and a group of healthy adult subjects (n = 30) as a normal control (NC). Results: The primary outcome is the change in subjective and objective cognitive performance between baseline and postintervention visits (4 weeks after baseline). Secondary outcomes include changes in performance assessing from baseline, postintervention to follow-up (3 months after the intervention), as well as sleep, mood, and physiological parameters (including blood, urine, electrophysiology, and neuroimaging biomarkers). Conclusion: This study aims to provide evidence of the impact of light therapy on subjective and objective cognitive performance in middle-aged and older adults with SCD or aMCI. In addition, we will identify possible neurophysiological mechanisms of action underlying light therapy. Overall, this trial will contribute to the establishment of light therapy in the prevention of Alzheimer’s disease.

scholarly journals White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline

2021 ◽  
Vol 13 ◽  
Author(s):  
Yi-Chia Wei ◽  
Chih-Chin Heather Hsu ◽  
Wen-Yi Huang ◽  
Yao-Liang Chen ◽  
Chemin Lin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
White Matter ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Physical Inactivity ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Corona Radiata ◽  
Moca Score

Objective: Although previous studies postulated that physical and cognitive decline codeveloped in preclinical dementia, the interconnected relationship among subjective cognitive complaints (SCCs), objective cognitive performance, and physical activity remained hazy. We investigated the mediating roles of physical activity between subjective and objective cognition. Diffusion tensor imaging (DTI) was utilized to test our hypothesis that brain white matter microstructural changes underlie the physical-cognitive decline in subjective cognitive decline (SCD).Methods: We enrolled cognitively normal older adults aged > 50 years in the Community Medicine Research Center of Keelung Chang Gung Memorial Hospital during 2017–2020. Regression models analyzed mediation effects of physical activity between subjective and objective cognition. The self-reported AD8 questionnaire assessed SCCs. The SCD group, defined by AD8 score ≥ 2, further underwent diffusion MRI scans. Those who agreed to record actigraphy also wore the SOMNOwatch™ for 72 h. Spearman's correlation coefficients evaluated the associations of diffusion indices with physical activity and cognitive performance.Results: In 95 cognitively normal older adults, the AD8 score and the Montreal Cognitive Assessment (MoCA) score were mediated partially by the metabolic equivalent of the International Physical Activity Questionnaire-Short Form (IPAQ-SF MET) and fully by the sarcopenia score SARC-F. That is, the relation between SCCs and poorer cognitive performance was mediated by physical inactivity. The DTI analysis of 31 SCD participants found that the MoCA score correlated with mean diffusivity at bilateral inferior cerebellar peduncles and the pyramids segment of right corticospinal tract [p < 0.05, false discovery rate (FDR) corrected]. The IPAQ-SF MET was associated with fractional anisotropy (FA) at the right posterior corona radiata (PCR) (p < 0.05, FDR corrected). In 15 SCD participants who completed actigraphy recording, the patterns of physical activity in terms of intradaily variability and interdaily stability highly correlated with FA of bilateral PCR and left superior corona radiata (p < 0.05, FDR corrected).Conclusions: This study addressed the role of physical activity in preclinical dementia. Physical inactivity mediated the relation between higher SCCs and poorer cognitive performance. The degeneration of specific white matter tracts underlay the co-development process of physical-cognitive decline in SCD.

P4-353: SPECIFIC FEATURES OF SUBJECTIVE COGNITIVE DECLINE ARE RELATED TO AMYLOID AND TAU PATHOLOGY IN COGNITIVELY HEALTHY OLDER ADULTS

2019 ◽  
Vol 15 ◽  
pp. P1433-P1434
Author(s):  
Sietske A.M. Sikkes ◽  
Jennifer R. Gatchel ◽  
Rachel F. Buckley ◽  
Mark A. van de Wiel ◽  
Dorene M. Rentz ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Tau Pathology ◽  
Healthy Older Adults

F4-08-04: SUBJECTIVE COGNITIVE DECLINE, AS MEASURED WITH A STRUCTURED INTERVIEW, IS RELATED TO AMYLOID PATHOLOGY IN COGNITIVELY HEALTHY OLDER ADULTS

2006 ◽  
Vol 14 (7S_Part_26) ◽  
pp. P1396-P1396
Author(s):  
Lisa Miebach ◽  
Steffen Wolfsgruber ◽  
Ingo Frommann ◽  
Sandra Roeske ◽  
Peters Oliver ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Structured Interview ◽  
Subjective Cognitive Decline ◽  
Healthy Older Adults ◽  
Amyloid Pathology

scholarly journals Cognitive Performance in Older Adults With Subjective Cognitive Decline

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 291-291
Author(s):  
Vanessa Taler ◽  
Cassandra Morrison ◽  
Christine Sheppard
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Subsequent Development ◽  
Word Recall ◽  
Subjective Cognitive Decline ◽  
Semantic Features ◽  
Lower Performance ◽  
Word Finding

Abstract Subjective cognitive decline (SCD) refers to a perceived decline in cognitive function in the absence of neuropsychological deficits. Older adults with SCD are at increased of subsequent development of mild cognitive impairment or dementia. We had 224 adults aged 65+ complete questionnaires assessing their subjective appraisal of their cognitive function, including questions about word-finding difficulty, memory, and attention/concentration. Participants also completed the Montreal Cognitive Assessment (MoCA). All participants exhibited cognitive performance that was within normal limits for age and education. In total, 29.5% of participants reported word-finding difficulties, 16.5% reported difficulties with remembering things, and 8.5% reported difficulties with attention/concentration. We found that (1) self-reported word-finding difficulties were associated with lower performance on delayed word recall, and (2) self-reported difficulties in concentration/attention or memory were associated with lower performance on the abstraction subtask in the MoCA. No other MoCA subtasks were associated with self-reported cognitive function. A subset of the participants (n=69) also completed a battery of tasks assessing semantic function, including picture naming, associative matching tasks, identification of semantic features, and semantic questions. Again, self-reported word-finding difficulty predicted lower performance on semantic tasks. These results suggest that older adults may be aware of changes in their cognitive performance prior to objective neuropsychological impairment. Moreover, their awareness appears to be domain-specific: self-reported language difficulty is associated with lower performance on language-based tasks, while self-reported difficulty in memory, attention, or concentration is associated with lower performance on an abstraction task.

Sign in / Sign up

Export Citation Format

Share Document