scholarly journals Sex-Specific Association of Lifetime Body Mass Index with Alzheimer’s Disease Neuroimaging Biomarkers

2020 ◽  
Vol 75 (3) ◽  
pp. 767-777
Author(s):  
Seung Hoon Lee ◽  
Min Soo Byun ◽  
Jun Ho Lee ◽  
Dahyun Yi ◽  
Bo Kyung Sohn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Neuroimaging Biomarkers ◽  
Specific Association

Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer’s Disease: The Shanghai Aging Study

2020 ◽  
Vol 17 (2) ◽  
pp. 185-195
Author(s):  
Jianxiong Xi ◽  
Ding Ding ◽  
Qianhua Zhao ◽  
Xiaoniu Liang ◽  
Li Zheng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Body Mass ◽  
Joint Effect ◽  
Genome Wide Association Studies ◽  
Risk Genotype ◽  
Aging Study

Background: Approximately 40 independent Single Nucleotide Polymorphisms (SNPs) have been associated with Alzheimer’s Disease (AD) or cognitive decline in genome-wide association studies. Methods: We aimed to evaluate the joint effect of genetic polymorphisms and environmental factors on the progression from Mild Cognitive Impairment (MCI) to AD (MCI-AD progression) in a Chinese community cohort. Conclusion: Demographic, DNA and incident AD diagnosis data were derived from the follow-up of 316 participants with MCI at baseline of the Shanghai Aging Study. The associations of 40 SNPs and environmental predictors with MCI-AD progression were assessed using the Kaplan-Meier method with the log-rank test and Cox regression model. Results: Rs4147929 at ATP-binding cassette family A member 7 (ABCA7) (AG/AA vs. GG, hazard ratio [HR] = 2.43, 95% confidence interval [CI] 1.24-4.76) and body mass index (BMI) (overweight vs. non-overweight, HR = 0.41, 95% CI 0.22-0.78) were independent predictors of MCI-AD progression. In the combined analyses, MCI participants with the copresence of non-overweight BMI and the ABCA7 rs4147929 (AG/AA) risk genotype had an approximately 6-fold higher risk of MCI-AD progression than those with an overweight BMI and a non-risk genotype (HR = 6.77, 95% CI 2.60-17.63). However, a nonsignificant result was found when participants carried only one of these two risk factors (nonoverweight BMI and AG/AA of ABCA7 rs4147929). Conclusion: ABCA7 rs4147929 and BMI jointly affect MCI-AD progression. MCI participants with the rs4147929 risk genotype may benefit from maintaining an overweight BMI level with regard to their risk for incident AD.

scholarly journals Physical activity, body mass index, and brain atrophy in Alzheimer's disease

2015 ◽  
Vol 36 ◽  
pp. S194-S202 ◽  
Author(s):  
Christina P. Boyle ◽  
Cyrus A. Raji ◽  
Kirk I. Erickson ◽  
Oscar L. Lopez ◽  
James T. Becker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Brain Atrophy

scholarly journals Body mass index is associated with smaller medial temporal lobe volume in those at risk for Alzheimer's disease

2020 ◽  
Vol 25 ◽  
pp. 102156
Author(s):  
Jasmeet P. Hayes ◽  
Jena N. Moody ◽  
Juan Guzmán Roca ◽  
Scott M. Hayes
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
At Risk ◽  
Body Mass ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

Determinants and Detection of Low Body Mass Index in Community-Dwelling Adults With Alzheimer's Disease

2000 ◽  
Vol 12 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Michel Bédard ◽  
D. William Molloy ◽  
Rhonda Bell ◽  
Judy A. Lever
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
At Risk ◽  
Body Mass ◽  
Community Dwelling ◽  
Assessment Protocol ◽  
Geriatric Clinic ◽  
Low Body Mass Index ◽  
Low Bmi

Objective: To determine the proportion of older adults with Alzheimer's disease presenting to a geriatric clinic with low body mass index (BMI), the proportion of these individuals recognized by clinicians as malnourished, and what patients' characteristics and caregivers' and clinicians' impressions are associated with low BMI. Design: Cross-sectional study. Setting: An outpatient geriatric clinic located in a university-affiliated teaching hospital. Participants: 340 patients with Alzheimer's disease, average age 75 years. Measurements: Individuals with a BMI below 21 were considered at risk of malnutrition. Physical examination and medical information were obtained from patients and caregivers by clinicians using a standardized assessment protocol. Clinicians' impression regarding evidence of malnutrition was obtained. Results: Forty-six patients (16%) had a BMI below 21. Clinicians reported evidence of potential malnutrition in 11 patients, 8 of whom had a BMI below 21. Using logistic regression, we found that women were five times more likely to have a BMI below 21 than men, and that individuals with low cognition were twice as likely to have a BMI below 21 than individuals with higher cognition. Conclusion: The proportion of patients with Alzheimer's disease with a BMI below 21 is similar to that encountered in the general population aged 65+. However, clinicians have difficulty identifying persons at risk of malnutrition according to BMI status. Women with low cognition were at increased risk of having a low BMI. Improvement in the detection of malnutrition is desirable. Further exploration of causal links between cognition and malnutrition is required.

scholarly journals Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses

2015 ◽  
Vol 11 (12) ◽  
pp. 1439-1451 ◽  
Author(s):  
Shubhabrata Mukherjee ◽  
Stefan Walter ◽  
John S.K. Kauwe ◽  
Andrew J. Saykin ◽  
David A. Bennett ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Large Samples

scholarly journals Change in Body Mass Index Before and After Alzheimer’s Disease Onset

2014 ◽  
Vol 11 (4) ◽  
pp. 349-356 ◽  
Author(s):  
Yian Gu ◽  
Nikolaos Scarmeas ◽  
Stephanie Cosentino ◽  
Jason Brandt ◽  
Marilyn Albert ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Disease Onset ◽  
Before And After
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