scholarly journals Increased Cerebrospinal Fluid Amyloid-β During Sleep Deprivation in Healthy Middle-Aged Adults Is Not Due to Stress or Circadian Disruption

2020 ◽  
Vol 75 (2) ◽  
pp. 471-482 ◽  
Author(s):  
Margaret S. Blattner ◽  
Sunil K. Panigrahi ◽  
Cristina D. Toedebusch ◽  
Terry J. Hicks ◽  
Jennifer S. McLeland ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Sleep Deprivation ◽  
Amyloid Β ◽  
Circadian Disruption ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition tests

2017 ◽  
Vol 56 (2) ◽  
pp. 763-774 ◽  
Author(s):  
Herman Borghys ◽  
Bianca Van Broeck ◽  
Deborah Dhuyvetter ◽  
Tom Jacobs ◽  
Katja de Waepenaert ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Middle Aged

O2-01-07: Baseline cerebrospinal fluid markers in healthy middle-aged adults predict brain health at three-year follow-up

2011 ◽  
Vol 7 ◽  
pp. e4-e4
Author(s):  
Barbara Bendlin ◽  
Aparna Sodhi ◽  
Auriel Willette ◽  
Sterling Johnson ◽  
Michele Ries ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Health ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition

2015 ◽  
Vol 21 (10) ◽  
pp. 841-850 ◽  
Author(s):  
Stephanie A. Schultz ◽  
Elizabeth A. Boots ◽  
Rodrigo P. Almeida ◽  
Jennifer M. Oh ◽  
Jean Einerson ◽  
...  
Keyword(s):  
At Risk ◽  
Cardiorespiratory Fitness ◽  
Exercise Test ◽  
Verbal Learning ◽  
Amyloid Β ◽  
Peak Oxygen Consumption ◽  
Middle Aged ◽  
Pittsburgh Compound B ◽  
Immediate Memory ◽  
Middle Aged Adults

AbstractThe aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements in cognition in a cohort of late-middle-aged adults at risk for Alzheimer’s disease (AD). Sixty-nine enrollees in the Wisconsin Registry for Alzheimer’s Prevention participated in this study. They completed a comprehensive neuropsychological exam, underwent 11C Pittsburgh Compound B (PiB)-PET imaging, and performed a graded treadmill exercise test to volitional exhaustion. Peak oxygen consumption (VO2peak) during the exercise test was used as the index of CRF. Forty-five participants also underwent lumbar puncture for collection of cerebrospinal fluid (CSF) samples, from which Aβ42 was immunoassayed. Covariate-adjusted regression analyses were used to test whether the association between Aβ and cognition was modified by CRF. There were significant VO2peak*PiB-PET interactions for Immediate Memory (p=.041) and Verbal Learning & Memory (p=.025). There were also significant VO2peak*CSF Aβ42 interactions for Immediate Memory (p<.001) and Verbal Learning & Memory (p<.001). Specifically, in the context of high Aβ burden, that is, increased PiB-PET binding or reduced CSF Aβ42, individuals with higher CRF exhibited significantly better cognition compared with individuals with lower CRF. In a late-middle-aged, at-risk cohort, higher CRF is associated with a diminution of Aβ-related effects on cognition. These findings suggest that exercise might play an important role in the prevention of AD. (JINS, 2015, 21, 841–850)

scholarly journals Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men

2014 ◽  
Vol 71 (8) ◽  
pp. 971 ◽  
Author(s):  
Sharon Ooms ◽  
Sebastiaan Overeem ◽  
Kees Besse ◽  
Marcel Olde Rikkert ◽  
Marcel Verbeek ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Sleep Deprivation ◽  
Middle Aged ◽  
Total Sleep Deprivation ◽  
Β Amyloid

Effects of Simvastatin on Cerebrospinal Fluid Biomarkers and Cognition in Middle-Aged Adults at Risk for Alzheimer's Disease

2008 ◽  
Vol 13 (2) ◽  
pp. 187-197 ◽  
Author(s):  
Cynthia M. Carlsson ◽  
Carey E. Gleason ◽  
Timothy M. Hess ◽  
Kimberly A. Moreland ◽  
Hanna M. Blazel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cerebrospinal Fluid ◽  
Middle Aged ◽  
Cerebrospinal Fluid Biomarkers ◽  
Middle Aged Adults

P3-034 Cerebrospinal fluid beta-amyloid-42 and tau levels in non-demented middle-aged adults at increased risk of developing Alzheimer's disease

2004 ◽  
Vol 25 ◽  
pp. S361
Author(s):  
Cynthia M. Carlsson ◽  
Carey E. Gleason ◽  
Kimberly Arnold ◽  
Tracy L. Ohrt ◽  
Angela Slattery ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Beta Amyloid ◽  
Middle Aged ◽  
Increased Risk ◽  
Middle Aged Adults
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