Functional Connectivity of Default Mode Network Subsystems in the Presymptomatic Stage of Autosomal Dominant Alzheimer’s Disease

2020 ◽  
Vol 73 (4) ◽  
pp. 1435-1444 ◽  
Author(s):  
Tan Zhao ◽  
Meina Quan ◽  
Jianping Jia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Autosomal Dominant ◽  
Default Mode ◽  
Autosomal Dominant Alzheimer’S Disease ◽  
Presymptomatic Stage

scholarly journals Cognitive Improvement is Correlated with Increased Dynamic Functional Connectivity of Default Mode Network by Personalized rTMS in Alzheimer's Disease

2021 ◽  
Author(s):  
Lili Wei ◽  
Jintao Wang ◽  
Yingchun Zhang ◽  
Luoyi Xu ◽  
Kehua Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Present Report ◽  
Verbal Learning ◽  
Dynamic Functional Connectivity ◽  
Default Mode ◽  
Cognitive Improvement ◽  
Promising Therapeutic Approach

Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is thought to be a promising therapeutic approach for Alzheimer's disease patients. Methods In the present report, a double-blind, randomized, sham-controlled rTMS trial was conducted in mild-to-moderate Alzheimer's disease patients. High-frequency rTMS was delivered to a subject-specific left lateral parietal region that demonstrated highest functional connectivity with the hippocampus using resting-state fMRI. The Mini Mental State Examination (MMSE) and Philadelphia Verbal Learning Test (PVLT) were used to evaluate patients’ cognitive functions. Results Patients receiving active rTMS treatment (n = 31) showed a significant increase in the MMSE, PVLT-Immediate recall, and PVLT-Short Delay recall scores after two weeks of rTMS treatment, whereas patients who received sham rTMS (n = 27) did not show significant changes in these measures. Dynamic functional connectivity (dFC) magnitude of the default mode network (DMN) in the active-rTMS group showed a significant increase after two weeks of rTMS treatment, and no significant changes were found in the sham-rTMS group. There was a significantly positive correlation between changes of the MMSE and changes of the dFC magnitude of DMN in the active-rTMS group, but not the sham-rTMS group. Conclusions Our findings are novel in demonstrating the feasibility and effectiveness of the fMRI-guided rTMS treatment in Alzheimer's disease patients, and DMN might play a vital role in therapeutic effectiveness of rTMS in Alzheimer’s disease. Trial registration: China National Medical Research Platform (http://114.255.48.20/login, No:MR-33-20-004217), retrospectively registered 2020-12-23.

scholarly journals Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants

2015 ◽  
Vol 36 (10) ◽  
pp. 2678-2686 ◽  
Author(s):  
Manja Lehmann ◽  
Cindee Madison ◽  
Pia M. Ghosh ◽  
Zachary A. Miller ◽  
Michael D. Greicius ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Early Onset ◽  
Default Mode ◽  
Early Onset Alzheimer’S Disease

IC-P-039: RACE MODIFIES FUNCTIONAL CONNECTIVITY OF THE DEFAULT MODE NETWORK IN AGING AND ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P40-P41
Author(s):  
Maria Misiura ◽  
William T. Hu ◽  
Jessica Turner ◽  
J Christina Howell
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Default Mode

P2-146: Temporo-parietal hypometabolism is associated with reduced functional connectivity of the default mode network in prodromal Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_11) ◽  
pp. P542-P542
Author(s):  
Lee Simon-Vermot ◽  
Yifei Zhang ◽  
Miguel Ángel Araque Caballero ◽  
Benno Gesierich ◽  
Lana Kambeitz-Ilankovic ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Default Mode ◽  
Prodromal Alzheimer’S Disease

P3-103: Relationship between anatomy and functional connectivity in default mode network in normal aging and mild Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P589-P590
Author(s):  
Thaís Hayata ◽  
Felipe Bergo ◽  
Brunno Campos ◽  
Alexandre Franco ◽  
Benito Damasceno ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Normal Aging ◽  
Default Mode
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