The Effect of Chronic Cerebral Hypoperfusion on Blood-Brain Barrier Permeability in a Transgenic Alzheimer’s Disease Mouse Model (PS1V97L)

2020 ◽  
Vol 74 (1) ◽  
pp. 261-275 ◽  
Author(s):  
Heyun Yang ◽  
Wei Wang ◽  
Longfei Jia ◽  
Wei Qin ◽  
Tingting Hou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Mouse Model ◽  
Blood Brain Barrier ◽  
Chronic Cerebral Hypoperfusion ◽  
Brain Barrier ◽  
Cerebral Hypoperfusion ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability

The Blood–Brain Barrier in Cognitive Decline and Alzheimer’s Disease

2020 ◽  
pp. 261-273
Author(s):  
Daniel A. Nation ◽  
Elissa McIntosh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Neurovascular Unit ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Brain Tissue Damage

The neurovascular unit is a multicellular organ that has attracted recent attention as a key microvascular regulator of cerebral blood flow and blood–brain barrier permeability that is implicated in homeostatic and pathological processes impacting cognitive function. Breakdown of the blood–brain barrier invariably causes brain tissue damage and dysfunction due to influx of toxic blood proteins, cells, ions and metals. Clinical studies employing markers of blood–brain barrier permeability suggest an important role in vascular and neurodegenerative dementias. The chapter discusses how the introduction of new neuroimaging and biomarker technologies has opened new pathways of investigation into the blood–brain function in Alzheimer’s disease.

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