Single-Nucleotide Polymorphisms Associated with the Senescence-Accelerated Phenotype of OXYS Rats: A Focus on Alzheimer’s Disease-Like and Age-Related-Macular-Degeneration-Like Pathologies

2020 ◽  
Vol 73 (3) ◽  
pp. 1167-1183 ◽  
Author(s):  
Vasiliy A. Devyatkin ◽  
Olga E. Redina ◽  
Nataliya G. Kolosova ◽  
Natalia A. Muraleva
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Nucleotide Polymorphisms ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Oxys Rats ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Age Related

scholarly journals Single Nucleotide Polymorphisms in MCP-1 and Its Receptor Are Associated with the Risk of Age Related Macular Degeneration

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49905 ◽  
Author(s):  
Akshay Anand ◽  
Neel Kamal Sharma ◽  
Amod Gupta ◽  
Sudesh Prabhakar ◽  
Suresh Kumar Sharma ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Age Related

scholarly journals Analysis of Single Nucleotide Polymorphisms in theNOS2AGene and Interaction with Smoking in Age-Related Macular Degeneration

2010 ◽  
Vol 74 (3) ◽  
pp. 195-201 ◽  
Author(s):  
Juan A. Ayala-Haedo ◽  
Paul J. Gallins ◽  
Patrice L. Whitehead ◽  
Stephen G. Schwartz ◽  
Jaclyn L. Kovach ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Age Related

scholarly journals Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen

2018 ◽  
Vol 136 (6) ◽  
pp. 682 ◽  
Author(s):  
Lisa Y. Lin ◽  
Qiang Zhou ◽  
Stephanie Hagstrom ◽  
Maureen G. Maguire ◽  
Ebenezer Daniel ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Age Related

miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)

2017 ◽  
Vol 55 (5) ◽  
Author(s):  
John Paul SanGiovanni ◽  
Peter M. SanGiovanni ◽  
Przemysław Sapieha ◽  
Vincent De Guire
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Macular Degeneration ◽  
Integrated Approach ◽  
Age Related Macular Degeneration ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Public Health Significance ◽  
Age Related ◽  
Micro Rnas ◽  
Health Significance

AbstractAdvanced age-related macular degeneration (AAMD) is a complex sight-threating disease of public health significance. Micro RNAs (miRNAs) have been proposed as biomarkers for AAMD. The presence of certain single nucleotide polymorphisms (SNPs) may influence the explanatory value of these biomarkers. Here we present findings from an integrated approach used to determine whether AAMD-associated SNPs have the capacity to influence miRNA-mRNA pairing and, if so, to what extent such pairing may be manifested in a discrete AAMD transcriptome. Using a panel of 8854 SNPs associated with AAMD at p-values ≤5.0E−7 from a cohort of >30,000 elderly people, we identified SNPs in miRNA target-encoding constituents of: (1) regulator of complement activation (RCA) genes (rs390679,

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