scholarly journals Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer’s Disease: A Preliminary Approach

2020 ◽  
Vol 73 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Philippos Koulousakis ◽  
Daniel van den Hove ◽  
Veerle Visser-Vandewalle ◽  
Thibaut Sesia
Keyword(s):  
Alzheimer’S Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rat Model ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Transgenic Rat ◽  
Transgenic Rat Model ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer's Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Wei Zhang ◽  
Wei Liu ◽  
Bhavana Patel ◽  
Yingchuan Chen ◽  
Kailiang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Brain Stimulation ◽  
Cognitive Function ◽  
Brain Stimulation ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Disease Assessment ◽  
Deep Brain ◽  
Stimulation Of

Patients with advanced Alzheimer's disease (AD) experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD (Clinical Dementia Rating scale: 3.0 points) underwent surgery for bilateral NBM-DBS electrode placement. After 10 weeks of stimulation, Mini-Mental State Examination (MMSE) assessment improved from a score of 5 to 9 points, and assessment using the Alzheimer's Disease Assessment Scale–Cognitive Subscale (ADAS-cog) showed a marked reduction in total score from 43 to 33 points, suggesting cognitive benefits from NBM-DBS. The patient's postoperative course was complicated by a subdural effusion that occurred several days after surgery, with complete recovery. Interestingly, the subject also displayed abnormal thermoregulation with stimulation initiation and stimulation parameter modifications. NBM-DBS may serve as a potential therapy for severe AD patients.Clinical Trial Registration: ChiCTR1900022324.

scholarly journals Cognitive Improvements after Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer’s disease; a Preliminary Approach

2019 ◽  
Author(s):  
Philippos Koulousakis ◽  
Daniel van den Hove ◽  
Veerle Visser-Vandewalle ◽  
Thibaut Sesia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Memory Task ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Transgenic Rat ◽  
Cognitive Benefits ◽  
Deep Brain

AbstractBackgroundDeep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has shown to have promising results in a pilot study with patients suffering from Alzheimer’s disease (AD). A recent study in aged monkeys shows a novel intermittent stimulation pattern to have superior cognitive benefits over continuous paradigms.Objective/HypothesisWe aimed at comparing the cognitive effects elicited by intermittent and continuous NBM stimulation paradigms in an animal model for AD (TgF344-AD rat line; TG), i.e. rats expressing mutant human amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9) genes, each independent causes of early-onset familial AD.MethodsIn this exploratory study, aged APP/PS1 rats were tested pre-, and post implantation with several stimulation parameters, i.e. unilateral- or bilateral-intermittent, and bilateral-continuous, while performing various behavioral tasks (open field, novel object recognition, and modified Barnes maze).Results and ConclusionBilateral-intermittent NBM DBS allowed aged TG rats to perform better and maintain their performance longer in a spatial memory task, as compared to other conditions. These data support the notion that NBM DBS could be further refined in the clinic, thereby improving patient care.

scholarly journals Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

2014 ◽  
Vol 20 (3) ◽  
pp. 353-360 ◽  
Author(s):  
J Kuhn ◽  
K Hardenacke ◽  
D Lenartz ◽  
T Gruendler ◽  
M Ullsperger ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Alzheimer’S Dementia ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Alzheimer's Dementia ◽  
Deep Brain ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document