Voluntary Wheel Running Reduces Amyloid-β42 and Rescues Behavior in Aged Tg2576 Mouse Model of Alzheimer’s Disease

2020 ◽  
Vol 73 (1) ◽  
pp. 359-374 ◽  
Author(s):  
Nikita Francis ◽  
Lisa S. Robison ◽  
Dominique L. Popescu ◽  
Michalis Michaelos ◽  
Joshua Hatfield ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Wheel Running ◽  
Tg2576 Mouse ◽  
Voluntary Wheel Running ◽  
Model Of Alzheimer’S Disease ◽  
Voluntary Wheel

scholarly journals Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Martina Svensson ◽  
Emelie Andersson ◽  
Oscar Manouchehrian ◽  
Yiyi Yang ◽  
Tomas Deierborg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Wheel Running ◽  
Synaptic Proteins ◽  
Voluntary Wheel Running ◽  
Voluntary Running ◽  
5Xfad Mouse ◽  
5Xfad Mice ◽  
Voluntary Wheel

AbstractPhysical exercise has been suggested to reduce the risk of developing Alzheimer’s disease (AD) as well as ameliorate the progression of the disease. However, we recently published results from two large epidemiological studies showing no such beneficial effects on the development of AD. In addition, long-term, voluntary running in the 5xFAD mouse model of AD did not affect levels of soluble amyloid beta (Aβ), synaptic proteins or cognitive function. In this follow-up study, we investigate whether running could impact other pathological aspects of the disease, such as insoluble Aβ levels, the neuroinflammatory response and non-cognitive behavioral impairments. We investigated the effects of 24 weeks of voluntary wheel running in female 5xFAD mice (n = 30) starting at 2–3 months of age, before substantial extracellular plaque formation. Running mice developed hindlimb clasping earlier (p = 0.009) compared to sedentary controls. Further, running exacerbated the exploratory behavior in Elevated plus maze (p = 0.001) and anxiety in Open field (p = 0.024) tests. Additionally, microglia, cytokines and insoluble Aβ levels were not affected. Taken together, our findings suggest that voluntary wheel running is not a beneficial intervention to halt disease progression in 5xFAD mice.

scholarly journals Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76497 ◽  
Author(s):  
Alice Krezymon ◽  
Kevin Richetin ◽  
Hélène Halley ◽  
Laurent Roybon ◽  
Jean-Michel Lassalle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Adult Neurogenesis ◽  
Tg2576 Mouse ◽  
Model Of Alzheimer’S Disease

scholarly journals Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease

2019 ◽  
Vol 13 ◽  
Author(s):  
Corinna Höfling ◽  
Emira Shehabi ◽  
Peer-Hendrik Kuhn ◽  
Stefan F. Lichtenthaler ◽  
Maike Hartlage-Rübsamen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgene Expression ◽  
Tg2576 Mouse ◽  
Cell Type ◽  
Model Of Alzheimer’S Disease ◽  
Cell Type Specific

Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease

2013 ◽  
Vol 1491 ◽  
pp. 117-126 ◽  
Author(s):  
Yasushi Kishimoto ◽  
Erina Higashihara ◽  
Akiko Fukuta ◽  
Akira Nagao ◽  
Yutaka Kirino
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Mouse Model ◽  
Tg2576 Mouse ◽  
Model Of Alzheimer’S Disease

scholarly journals Correction to: ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

2020 ◽  
Vol 140 (5) ◽  
pp. 791-791
Author(s):  
Charles E. Evans ◽  
James S. Miners ◽  
Giulia Piva ◽  
Christine L. Willis ◽  
David M. Heard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Decline ◽  
Tg2576 Mouse ◽  
Amyloid Pathology ◽  
Model Of Alzheimer’S Disease
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