scholarly journals A Comparative Study of Pathological Outcomes in The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age and Brains for Dementia Research Cohorts

2020 ◽  
Vol 73 (2) ◽  
pp. 619-632 ◽  
Author(s):  
Andrew C. Robinson ◽  
Stephen Chew-Graham ◽  
Yvonne S. Davidson ◽  
Michael A. Horan ◽  
Federico Roncaroli ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Comparative Study ◽  
Old Age ◽  
Dementia Research ◽  
The University ◽  
University Of Manchester

The University of Manchester longitudinal study of cognition in normal healthy old age, 1983 through 2003

2019 ◽  
pp. 220-268
Author(s):  
P.M.A. Rabbitt ◽  
L. McInnes ◽  
P. Diggle ◽  
F. Holland ◽  
N. Bent ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Old Age ◽  
The University ◽  
University Of Manchester

scholarly journals Pathological Correlates of Cognitive Impairment in The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age

2018 ◽  
Vol 64 (2) ◽  
pp. 483-496 ◽  
Author(s):  
Andrew C. Robinson ◽  
Yvonne S. Davidson ◽  
Michael A. Horan ◽  
Neil Pendleton ◽  
David M.A. Mann
Keyword(s):  
Cognitive Impairment ◽  
Longitudinal Study ◽  
Old Age ◽  
The University ◽  
University Of Manchester

The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age, 1983 through 2003

2004 ◽  
Vol 11 (2-3) ◽  
pp. 245-279 ◽  
Author(s):  
P.M.A. Rabbitt ◽  
L. McInnes ◽  
P. Diggle ◽  
F. Holland ◽  
N. Bent ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Old Age ◽  
The University ◽  
University Of Manchester

scholarly journals Influence of APOE genotype in primary age-related tauopathy

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Andrew C. Robinson ◽  
Yvonne S. Davidson ◽  
Federico Roncaroli ◽  
James Minshull ◽  
Phillip Tinkler ◽  
...  
Keyword(s):  
Apoe Genotype ◽  
Protein Isoforms ◽  
Elderly Subjects ◽  
Cognitively Impaired ◽  
Age Related ◽  
Dementia Research ◽  
Amyloid Aβ ◽  
The University ◽  
University Of Manchester ◽  
The Impact

AbstractThe term “Primary age-related tauopathy” (PART) was coined in 2014 to describe the common neuropathological observation of neurofibrillary tangles without associated beta-amyloid (Aβ) pathology. It is possible for PART pathology to be present in both cognitively normal and cognitively impaired individuals. Genetically, Apolipoprotein E (APOE) ε4 has been shown to occur less commonly in PART than in Alzheimer’s disease (AD). Here, we investigate the relationships between PART, AD and those pathologically normal for age, with an emphasis on APOE and cognition, using 152 selected participants from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age and the Manchester arm of the Brains for Dementia Research cohort. APOE genotype differed between PART and AD with APOE ε2 more common in the former and APOE ε4 more common in the latter. Individuals with definite PART were less likely to be cognitively impaired than those with AD and those with pathology considered pathologically normal for age. We postulate that the lack of Aβ in definite PART cases may be due either to an increased frequency of APOE ε2 or decreased frequency of APOE ε4 as their resulting protein isoforms have differing binding properties in relation to Aβ. Similarly, an increased frequency of APOE ε2 or decreased frequency of APOE ε4 may lead to decreased levels of cognitive impairment, which raises questions regarding the impact of Aβ pathology on overall cognition in elderly subjects. We suggest that it may be possible to use the increased frequency of APOE ε2 in definite PART to assist neuropathological diagnosis.

scholarly journals Sydney Cross Harland, 19 July 1891 - 8 November 1982

1984 ◽  
Vol 30 ◽  
pp. 297-316
Keyword(s):  
High School ◽  
Old Age ◽  
West Indies ◽  
The West ◽  
King's College ◽  
Village School ◽  
The University ◽  
University Of Manchester ◽  
The Village ◽  
Textile Institute

Sydney Cross Harland was born in Snainton, near Scarborough, Yorkshire, on 19 July 1891. He went to school, first in the village school and then at Scarborough High School. From there he was awarded a scholarship, and went to King’s College, London, and read geology. He graduated with honours in 1912. He grew up a short, stocky man. He was brisk and active in his movements, in spite of a limp which he had through out his life. He went overseas and worked in the West Indies, Brazil and Peru. Here turned to England to become Reader in Genetics and then Professor of Botany in the University of Manchester. In 1919, while working in the West Indies, he was awarded a D.Sc. in botany by King’s College, London. He was elected F. R. S. in 1943 and F.R.S.E. in 1951, and he was made an Honorary Fellow of the Textile Institute for his work on the technological characters of raw cotton. When he retired he lived for some time in Blackheath and then on a property he had acquired in Peru. In old age he returned to a house he had owned since 1932 in Snainton, and there he died on 8 November 1982, at the age of 91.

scholarly journals SOPTI Meeting Abstracts 2021

2021 ◽  
Vol 14 (2) ◽  
pp. 1-3
Author(s):  
Alberto Recchioni
Keyword(s):  
Old Age ◽  
Contact Lenses ◽  
Good Practice ◽  
National Conference ◽  
South Eastern ◽  
The University ◽  
University Of Manchester ◽  
Eastern Norway

After more than a year of blockade due to the Covid-19 pandemic, it was finally possible to return to the events in the presence. The 26th National Conference of the Italian Optometric Association (SOPTI) was held in Bologna on October 10–11, 2021. The theme of the conference was “Good practice in Optometry and Contact Lenses”, with the accent on two topics: the optometric management of the patient in old age and the progression of myopia. Four keynote speakers were invited during the conference: Prof. Rigmor C. Baraas from the University of South-Eastern Norway in Kongsberg, Prof. David B. Elliot from the University of Bradford, Dr. Fabrizio Zeri from the University of Milano Bicocca and the IACLE President, Prof. Phil Morgan, from the University of Manchester. The abstracts from accepted posters and free papers are presented here.

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