scholarly journals Geographical Variation in Opioid Use in Elderly Patients with Dementia: A Nationwide Study

2019 ◽  
Vol 70 (4) ◽  
pp. 1209-1216
Author(s):  
Christina Jensen-Dahm ◽  
Johanne Købstrup Zakarias ◽  
Christiane Gasse ◽  
Gunhild Waldemar
Keyword(s):  
Elderly Patients ◽  
Geographical Variation ◽  
Opioid Use ◽  
Nationwide Study

scholarly journals Geographical Variation in Antipsychotic Drug Use in Elderly Patients with Dementia: A Nationwide Study

2016 ◽  
Vol 54 (3) ◽  
pp. 1183-1192 ◽  
Author(s):  
Johanne Købstrup Zakarias ◽  
Christina Jensen-Dahm ◽  
Ane Nørgaard ◽  
Lea Stevnsborg ◽  
Christiane Gasse ◽  
...  
Keyword(s):  
Drug Use ◽  
Elderly Patients ◽  
Antipsychotic Drug ◽  
Geographical Variation ◽  
Nationwide Study

Trends in opioid use before critical illness among elderly patients in Ontario

2020 ◽  
Vol 55 ◽  
pp. 128-133
Author(s):  
Han Ting Wang ◽  
Andrea D. Hill ◽  
Tara Gomes ◽  
Ruxandra Pinto ◽  
Duminda N. Wijeysundera ◽  
...  
Keyword(s):  
Critical Illness ◽  
Elderly Patients ◽  
Opioid Use

Geographical variation in use of intensive care: a nationwide study

2015 ◽  
Vol 41 (11) ◽  
pp. 1895-1902 ◽  
Author(s):  
Anne Høy Seemann Vestergaard ◽  
Christian Fynbo Christiansen ◽  
Henrik Nielsen ◽  
Steffen Christensen ◽  
Søren Paaske Johnsen
Keyword(s):  
Intensive Care ◽  
Geographical Variation ◽  
Nationwide Study

scholarly journals HTX-011 effectively reduces postoperative pain intensity and opioid use in the elderly

2021 ◽  
Author(s):  
Tina Yip ◽  
Jia Hu ◽  
Pamela S Hawn ◽  
Amy Yamamoto ◽  
Gary Oderda
Keyword(s):  
Clinical Trial ◽  
Postoperative Pain ◽  
Elderly Patients ◽  
Pain Intensity ◽  
Local Anesthetic ◽  
Extended Release ◽  
The Elderly ◽  
Opioid Consumption ◽  
Opioid Use ◽  
Clinical Trial Registration

Aim: HTX-011 (ZYNRELEF™) is an extended-release, dual-acting local anesthetic containing bupivacaine and meloxicam. In bunionectomy and herniorrhaphy studies, HTX-011 resulted in less postoperative pain and less opioid consumption versus bupivacaine HCl. Here we evaluate HTX-011 in patients aged ≥65 years. Materials & methods: Patients received placebo, bupivacaine HCl or HTX-011 following surgery. End points included pain intensity, total opioid consumption, opioid-free patients and safety. Results: HTX-011-treated patients reported lower postoperative pain through 72 h versus bupivacaine HCl and placebo. Elderly patients administered HTX-011 used fewer opioids versus bupivacaine HCl, and a greater proportion remained opioid-free through 72 h. HTX-011 was well tolerated with a safety profile similar to bupivacaine HCl and placebo. Conclusion: HTX-011 maintained effectiveness and was well tolerated in elderly patients. Clinical Trial Registration: NCT03295721 and NCT03237481

Prescription opioid use among drivers in British Columbia, 1997–2016

2021 ◽  
pp. injuryprev-2020-043989
Author(s):  
John A Staples ◽  
Shannon Erdelyi ◽  
Jessica Moe ◽  
Mayesha Khan ◽  
Herbert Chan ◽  
...  
Keyword(s):  
British Columbia ◽  
Geographical Variation ◽  
Temporal Trends ◽  
Population Based ◽  
Opioid Consumption ◽  
Prescription Opioid ◽  
Prescription Data ◽  
Opioid Use ◽  
Opioid Prescription ◽  
Prescription Opioid Use

BackgroundOpioids increase the risk of traffic crash by limiting coordination, slowing reflexes, impairing concentration and producing drowsiness. The epidemiology of prescription opioid use among drivers remains uncertain. We aimed to examine population-based trends and geographical variation in drivers’ prescription opioid consumption.MethodsWe linked 20 years of province-wide driving records to comprehensive population-based prescription data for all drivers in British Columbia (Canada). We calculated age- and sex-standardised rates of prescription opioid consumption. We assessed temporal trends using segmented linear regression and examined regional variation in prescription opioid use using maps and graphical techniques.ResultsA total of 46 million opioid prescriptions were filled by 3.0 million licensed drivers between 1997 and 2016. In 2016 alone, 14.7% of all drivers filled at least one opioid prescription. Prescription opioid use increased from 238 morphine milligram equivalents per driver year (MMEs/DY) in 1997 to a peak of 834 MMEs/DY in 2011. Increases in MMEs/DY were greatest for higher potency and long-acting prescription opioids. The interquartile range of prescription opioid dispensation by geographical region increased from 97 (Q1=220, Q3=317) to 416 (Q1=591, Q3=1007) MMEs/DY over the study interval.ImplicationsPatterns of prescription opioid consumption among drivers demonstrate substantial temporal and geographical variation, suggesting they may be modified by clinical and policy interventions. Interventions to curtail use of potentially impairing prescription medications might prevent impaired driving.

scholarly journals Resection rate and operability of elderly patients with non-small cell lung cancer: Nationwide study from 1991 to 2014

2017 ◽  
Vol 24 (5) ◽  
pp. 733-739 ◽  
Author(s):  
Kristjan Baldvinsson ◽  
Gudrun Nina Oskarsdottir ◽  
Andri Wilberg Orrason ◽  
Hannes Halldorsson ◽  
Hunbogi Thorsteinsson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Resection Rate ◽  
Nationwide Study

scholarly journals Geographical Variation in Use of Intensive Care in Denmark: A Nationwide Study

2015 ◽  
Vol 3 (S1) ◽  
Author(s):  
AHS Vestergaard ◽  
CF Christiansen ◽  
H Nielsen ◽  
S Christensen ◽  
SP Johnsen
Keyword(s):  
Intensive Care ◽  
Geographical Variation ◽  
Nationwide Study
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