scholarly journals Altered Redox State in Whole Blood Cells from Patients with Mild Cognitive Impairment and Alzheimer’s Disease

2019 ◽  
Vol 71 (1) ◽  
pp. 153-163 ◽  
Author(s):  
Irene Martínez de Toda ◽  
Lara Miguélez ◽  
Carmen Vida ◽  
Eva Carro ◽  
Mónica De la Fuente
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Whole Blood ◽  
Blood Cells ◽  
Redox State ◽  
Whole Blood Cells

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

Biomarkers ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 196-201 ◽  
Author(s):  
Patricia Regina Manzine ◽  
Elena Marcello ◽  
Barbara Borroni ◽  
Willem Kamphuis ◽  
Elly Hol ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Blood Cells

scholarly journals Mitochondrial Alterations in Peripheral Mononuclear Blood Cells from Alzheimer’s Disease and Mild Cognitive Impairment Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
A. Delbarba ◽  
G. Abate ◽  
C. Prandelli ◽  
M. Marziano ◽  
L. Buizza ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mitochondrial Dna ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cytochrome C ◽  
Blood Cells ◽  
Healthy Subjects ◽  
Mononuclear Cells ◽  
Mitochondrial Dna Copy Number

It is well recognized that mitochondrial dysfunction contributes to neurodegeneration occurring in Alzheimer’s disease (AD). However, evidences of mitochondrial defects in AD peripheral cells are still inconclusive. Here, some mitochondrial-encoded and nuclear-encoded proteins, involved in maintaining the correct mitochondria machine, were investigated in terms of protein expression and enzymatic activity in peripheral blood mononuclear cells (PBMCs) isolated from AD and Mild Cognitive Impairment (MCI) patients and healthy subjects. In addition mitochondrial DNA copy number was measured by real time PCR. We found some differences and some similarities between AD and MCI patients when compared with healthy subjects. For example, cytochrome C and cytochrome B were decreased in AD, while MCI showed only a statistical reduction of cytochrome C. On the other hand, both AD and MCI blood cells exhibited highly nitrated MnSOD, index of a prooxidant environment inside the mitochondria. TFAM, a regulator of mitochondrial genome replication and transcription, was decreased in both AD and MCI patients’ blood cells. Moreover also the mitochondrial DNA amount was reduced in PBMCs from both patient groups. In conclusion these data confirmed peripheral mitochondria impairment in AD and demonstrated that TFAM and mtDNA amount reduction could be two features of early events occurring in AD pathogenesis.

Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer’s disease

Cytokine ◽  
2013 ◽  
Vol 61 (2) ◽  
pp. 360-363 ◽  
Author(s):  
Francesca Salani ◽  
Antonio Ciaramella ◽  
Federica Bizzoni ◽  
Francesca Assogna ◽  
Carlo Caltagirone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Blood Cells ◽  
Interleukin 18
Sign in / Sign up

Export Citation Format

Share Document