scholarly journals Degeneration of the Suprachiasmatic Nucleus in an Alzheimer’s Disease Mouse Model Monitored by in vivo Magnetic Resonance Relaxation Measurements and Immunohistochemistry

2019 ◽  
Vol 69 (2) ◽  
pp. 363-375 ◽  
Author(s):  
Upasana Roy ◽  
Mónica T. Heredia-Muñoz ◽  
Lara Stute ◽  
Corinna Höfling ◽  
Jörg Matysik ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Suprachiasmatic Nucleus ◽  
Relaxation Measurements ◽  
Resonance Relaxation

[18F]-florbetaben PET/CT Imaging in the Alzheimer’s Disease Mouse Model APPswe/PS1dE9

2018 ◽  
Vol 16 (1) ◽  
pp. 49-55 ◽  
Author(s):  
J. Stenzel ◽  
C. Rühlmann ◽  
T. Lindner ◽  
S. Polei ◽  
S. Teipel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
New Drugs ◽  
Imaging Data ◽  
Wild Type ◽  
Preclinical Research ◽  
Standardized Uptake Values ◽  
Pet Ct

Background: Positron-emission-tomography (PET) using 18F labeled florbetaben allows noninvasive in vivo-assessment of amyloid-beta (Aβ), a pathological hallmark of Alzheimer’s disease (AD). In preclinical research, [<sup>18</sup>F]-florbetaben-PET has already been used to test the amyloid-lowering potential of new drugs, both in humans and in transgenic models of cerebral amyloidosis. The aim of this study was to characterize the spatial pattern of cerebral uptake of [<sup>18</sup>F]-florbetaben in the APPswe/ PS1dE9 mouse model of AD in comparison to histologically determined number and size of cerebral Aβ plaques. Methods: Both, APPswe/PS1dE9 and wild type mice at an age of 12 months were investigated by smallanimal PET/CT after intravenous injection of [<sup>18</sup>F]-florbetaben. High-resolution magnetic resonance imaging data were used for quantification of the PET data by volume of interest analysis. The standardized uptake values (SUVs) of [<sup>18</sup>F]-florbetaben in vivo as well as post mortem cerebral Aβ plaque load in cortex, hippocampus and cerebellum were analyzed. Results: Visual inspection and SUVs revealed an increased cerebral uptake of [<sup>18</sup>F]-florbetaben in APPswe/ PS1dE9 mice compared with wild type mice especially in the cortex, the hippocampus and the cerebellum. However, SUV ratios (SUVRs) relative to cerebellum revealed only significant differences in the hippocampus between the APPswe/PS1dE9 and wild type mice but not in cortex; this differential effect may reflect the lower plaque area in the cortex than in the hippocampus as found in the histological analysis. Conclusion: The findings suggest that histopathological characteristics of Aβ plaque size and spatial distribution can be depicted in vivo using [<sup>18</sup>F]-florbetaben in the APPswe/PS1dE9 mouse model.

P3-251: Magnetic resonance biomarkers of neurodegeneration in a transgenic mouse model of Alzheimer's disease

2010 ◽  
Vol 6 ◽  
pp. S525-S525
Author(s):  
Malgorzata Marjanska ◽  
R. Chamberlain ◽  
G. Preboske ◽  
A. Polk ◽  
L. Kotilinek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Model Of Alzheimer’S Disease

In Vivo Magnetic Resonance of Amyloid Plaques in Alzheimer’s Disease Model Mice

2004 ◽  
pp. 47-59 ◽  
Author(s):  
Einar M. Sigurdsson ◽  
Youssef Zaim Wadghiri ◽  
Marcin Sadowski ◽  
James I. Elliott ◽  
Yongsheng Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Disease Model ◽  
Amyloid Plaques

In Vivo Perturbation of Lysosomal Function Promotes Neurodegeneration in the PS1M146V/APPK670N,M671L Mouse Model of Alzheimer's Disease Pathology

2003 ◽  
pp. 687-695 ◽  
Author(s):  
Ralph A. Nixon ◽  
Paul M. Mathews ◽  
Anne M. Cataldo ◽  
Panaiyur S. Mohan ◽  
Stephen D. Schmidt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Lysosomal Function ◽  
Model Of Alzheimer’S Disease

scholarly journals Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease

2012 ◽  
Vol 31 (s3) ◽  
pp. S87-S99 ◽  
Author(s):  
Vladimír Mlynárik ◽  
Matthias Cacquevel ◽  
Lili Sun-Reimer ◽  
Sharon Janssens ◽  
Cristina Cudalbu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mouse Model ◽  
Resonance Spectroscopy ◽  
Phosphorus Magnetic Resonance Spectroscopy ◽  
Model Of Alzheimer’S Disease
Sign in / Sign up

Export Citation Format

Share Document