scholarly journals Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling

2019 ◽  
Vol 67 (3) ◽  
pp. 1089-1106 ◽  
Author(s):  
Ci-Di Chen ◽  
Ella Zeldich ◽  
Christina Khodr ◽  
Kaddy Camara ◽  
Tze Yu Tung ◽  
...  
Keyword(s):  
Small Molecule ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Β Protein ◽  
Protein Precursor ◽  
Precursor Processing ◽  
Β Protein

scholarly journals A High-Throughput Screen to Identify Inhibitors of Amyloid β-Protein Precursor Processing

2005 ◽  
Vol 10 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Pancham Bakshi ◽  
Yung-Feng Liao ◽  
Jun Gao ◽  
Jake Ni ◽  
Ross Stein ◽  
...  
Keyword(s):  
High Throughput ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Β Protein ◽  
High Throughput Screen ◽  
Transcription Activator ◽  
Protein Precursor ◽  
App Processing ◽  
Chemical Structures ◽  
Β Protein

Cerebral accumulation of the amyloid β-peptide (Aβ) is believed to play a key role in the pathogenesis of Alzheimer’s disease (AD). Because Aβ is produced from the proteolysis of amyloid β-protein precursor (APP) by β-and γ-secretases, these enzymes are considered important drug targets for AD. The authors have developed a luciferase-based reporter system that can identify new molecules that inhibit APP processing in a high-throughput manner. Such molecules can help in understanding the biology of APP and APP processing and in developing new drug prototypes for AD. In this system, APP is fused on its C-terminus with Gal4-VP16, a chimeric yeast-viral transcription activator, and luciferase is under control of the yeast Gal4 promoter. Compounds that modulate the luciferase signal may affect the secretases directly, interact with modifiers of these proteases, or interact with APP directly. The authors successfully interfaced this assay with a high-throughput screen, testing ~60,000 compounds with diverse chemical structures. In principle, this sensitive, specific, and quantitative assay may be useful for identifying both inhibitors and stimulators of APP processing.( Journal of Biomolecular Screening 2005:1-12)

Transcranial Laser Therapy Attenuates Amyloid-β Peptide Neuropathology in Amyloid-β Protein Precursor Transgenic Mice

2011 ◽  
Vol 23 (3) ◽  
pp. 521-535 ◽  
Author(s):  
Luis De Taboada ◽  
Jin Yu ◽  
Salim El-Amouri ◽  
Sebastiano Gattoni-Celli ◽  
Steve Richieri ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Laser Therapy ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Β Protein ◽  
Protein Precursor ◽  
Β Protein

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the production of amyloid β peptide by BACE1 in vitro and in cells

2005 ◽  
Vol 7 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Xiao-Ping Shi ◽  
Katherine Tugusheva ◽  
James E. Bruce ◽  
Adam Lucka ◽  
Elizabeth Chen-Dodson ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Β Protein ◽  
Novel Mutations ◽  
Protein Precursor ◽  
Β Protein ◽  
In Cells

scholarly journals Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1

2009 ◽  
Vol 21 (4) ◽  
pp. 567-576 ◽  
Author(s):  
Michael A. Myre ◽  
Kevin Washicosky ◽  
Robert D. Moir ◽  
Giuseppina Tesco ◽  
Rudolph E. Tanzi ◽  
...  
Keyword(s):  
Small Molecule ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Precursor ◽  
Amyloidogenic Processing ◽  
Β Protein

Nicotine lowers the secretion of the Alzheimer's amyloid β-protein precursor that contains amyloid β-peptide in rat

2002 ◽  
Vol 4 (5) ◽  
pp. 405-415 ◽  
Author(s):  
Tadanobu Utsuki ◽  
Mohammed Shoaib ◽  
Harold W. Holloway ◽  
Donald K. Ingram ◽  
William C. Wallace ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Β Protein ◽  
Protein Precursor ◽  
Β Protein
Sign in / Sign up

Export Citation Format

Share Document