Pathological Changes in Alzheimer’s Disease Analyzed Using Induced Pluripotent Stem Cell-Derived Human Microglia-Like Cells

2019 ◽  
Vol 67 (1) ◽  
pp. 357-368 ◽  
Author(s):  
Mei Xu ◽  
Lin Zhang ◽  
Gang Liu ◽  
Ning Jiang ◽  
Wenxia Zhou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Pathological Changes ◽  
Human Microglia ◽  
Induced Pluripotent

scholarly journals NEUBOrg: artificially induced pluripotent stem cell-derived brain organoid to model and study genetics of Alzheimer’s disease progression.

2020 ◽  
Author(s):  
Sally Esmail ◽  
Wayne Danter
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Disease Progression ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Whole Brain ◽  
Learning Platform ◽  
Brain Organoid ◽  
Induced Pluripotent

Abstract Alzheimer's disease (AD) is the most common type of neurodegenerative diseases. There are over 44 million people living with the disease worldwide. While there are currently no effective treatments for AD, induced pluripotent stem cell-derived brain organoids have the potential to provide a better understanding of Alzheimer’s pathogenesis. Nevertheless, developing brain organoid models is expensive, time consuming and often does not reflect disease progression. Using accurate and inexpensive computer simulations of human brain organoids can overcome the current limitations. Induced whole brain organoids (aiWBO) will greatly expand our ability to model AD and can guide wet lab research. In this study, we have successfully developed and validated artificially induced a whole brain organoid platform (NEUBOrg) using our previously validated machine learning platform, DeepNEU (v6.1). Using NEUBorg platform, we have generated aiWBO simulations of AD and provided a novel approach to test genetic risk factors associated with AD progression and pathogenesis.

scholarly journals Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease

2016 ◽  
Vol 17 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Anna Ochalek ◽  
Csilla Nemes ◽  
Eszter Varga ◽  
Zsuzsanna Táncos ◽  
Julianna Kobolák ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Ipsc Line ◽  
Sporadic Alzheimer’S Disease ◽  
Induced Pluripotent
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