scholarly journals Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer’s Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity

2019 ◽  
Vol 69 (1) ◽  
pp. 15-35 ◽  
Author(s):  
Jorge Jovicich ◽  
Claudio Babiloni ◽  
Clarissa Ferrari ◽  
Moira Marizzoni ◽  
Davide V. Moretti ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Amnestic Mild Cognitive Impairment ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Prodromal Alzheimer’S Disease ◽  
Electroencephalographic Activity

scholarly journals Event-Related Functional Magnetic Resonance Imaging Changes during Relational Retrieval in Normal Aging and Amnestic Mild Cognitive Impairment

2012 ◽  
Vol 18 (5) ◽  
pp. 886-897 ◽  
Author(s):  
Kelly S. Giovanello ◽  
Felipe De Brigard ◽  
Jaclyn Hennessey Ford ◽  
Daniel I. Kaufer ◽  
James R. Burke ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Amnestic Mild Cognitive Impairment ◽  
Relational Memory ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Amci Group

AbstractThe earliest cognitive deficits observed in amnestic mild cognitive impairment (aMCI) appear to center on memory tasks that require relational memory (RM), the ability to link or integrate unrelated pieces of information. RM impairments in aMCI likely reflect neural changes in the medial temporal lobe (MTL) and posterior parietal cortex (PPC). We tested the hypothesis that individuals with aMCI, as compared to cognitively normal (CN) controls, would recruit neural regions outside of the MTL and PPC to support relational memory. To this end, we directly compared the neural underpinnings of successful relational retrieval in aMCI and CN groups, using event-related functional magnetic resonance imaging (fMRI), holding constant the stimuli and encoding task. The fMRI data showed that the CN, compared to the aMCI, group activated left precuneus, left angular gyrus, right posterior cingulate, and right parahippocampal cortex during relational retrieval, while the aMCI group, relative to the CN group, activated superior temporal gyrus and supramarginal gyrus for this comparison. Such findings indicate an early shift in the functional neural architecture of relational retrieval in aMCI, and may prove useful in future studies aimed at capitalizing on functionally intact neural regions as targets for treatment and slowing of the disease course. (JINS, 2012, 18, 1–12)

scholarly journals Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks

2009 ◽  
Vol 15 (3) ◽  
pp. 372-382 ◽  
Author(s):  
MARY M. MACHULDA ◽  
MATTHEW L. SENJEM ◽  
STEPHEN D. WEIGAND ◽  
GLENN E. SMITH ◽  
ROBERT J. IVNIK ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Temporal Cortex ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Complex Scene ◽  
Amnestic Mci

AbstractFunctional magnetic resonance imaging (fMRI) shows changes in multiple regions in amnestic mild cognitive impairment (aMCI). The concept of MCI recently evolved to include nonamnestic syndromes, so little is known about fMRI changes in these individuals. This study investigated activation during visual complex scene encoding and recognition in 29 cognitively normal (CN) elderly, 19 individuals with aMCI, and 12 individuals with nonamnestic MCI (naMCI). During encoding, CN activated an extensive network that included bilateral occipital–parietal–temporal cortex; precuneus; posterior cingulate; thalamus; insula; and medial, anterior, and lateral frontal regions. Amnestic MCI activated an anatomic subset of these regions. Non-amnestic MCI activated an even smaller anatomic subset. During recognition, CN activated the same regions observed during encoding except the precuneus. Both MCI groups again activated a subset of the regions activated by CN. During encoding, CN had greater activation than aMCI and naMCI in bilateral temporoparietal and frontal regions. During recognition, CN had greater activation than aMCI in predominantly temporoparietal regions bilaterally, while CN had greater activation than naMCI in larger areas involving bilateral temporoparietal and frontal regions. The diminished parietal and frontal activation in naMCI may reflect compromised ability to perform nonmemory (i.e., attention/executive, visuospatial function) components of the task. (JINS, 2009, 15, 372–382.)

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