scholarly journals Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia

2018 ◽  
Vol 66 (3) ◽  
pp. 1015-1025 ◽  
Author(s):  
Tyler E. Owens ◽  
Mary M. Machulda ◽  
Joseph R. Duffy ◽  
Edythe A. Strand ◽  
Heather M. Clark ◽  
...  
Keyword(s):  
Volume Changes ◽  
Neuropsychological Dysfunction ◽  
Cortical Volume ◽  
Logopenic Aphasia

An Exploratory Study on the Spatial Relationship Between Regional Cortical Volume Changes and White Matter Integrity in Multiple Sclerosis

2013 ◽  
Vol 3 (3) ◽  
pp. 255-264 ◽  
Author(s):  
Margit Jehna ◽  
Christian Langkammer ◽  
Michael Khalil ◽  
Siegrid Fuchs ◽  
Gernot Reishofer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Exploratory Study ◽  
Spatial Relationship ◽  
White Matter Integrity ◽  
Volume Changes ◽  
Cortical Volume

Brain volume changes over the first year of treatment in schizophrenia: relationships to antipsychotic treatment

2017 ◽  
Vol 47 (12) ◽  
pp. 2187-2196 ◽  
Author(s):  
R. Emsley ◽  
L. Asmal ◽  
S. du Plessis ◽  
B. Chiliza ◽  
L. Phahladira ◽  
...  
Keyword(s):  
White Matter ◽  
Effective Dose ◽  
Treatment Response ◽  
Volume Change ◽  
Brain Volume ◽  
Extrapyramidal Symptoms ◽  
Antipsychotic Treatment ◽  
Volume Changes ◽  
Cortical Volume ◽  
Therapeutic Benefits

BackgroundProgressive brain volume reductions have been described in schizophrenia, and an association with antipsychotic exposure has been reported.MethodsWe compared percentage changes in grey and white matter volume from baseline to month 12 in 23 previously antipsychotic-naïve patients with a first episode of schizophrenia or schizophreniform disorder who were treated with the lowest effective dose of flupenthixol decanoate depot formulation, with 53 matched healthy individuals. Total antipsychotic dose was precisely calculated and its relationship with brain volume changes investigated. Relationships between volumetric changes and treatment were further investigated in terms of treatment response (changes in psychopathology and functionality) and treatment-related adverse-events (extrapyramidal symptoms and weight gain).ResultsExcessive cortical volume reductions were observed in patients [−4.6 (6.6)%] v. controls [−1.12 (4.0)%] (p = 0.009), with no significant group differences for changes in subcortical grey matter and white matter volumes. In a multiple regression model, the only significant predictor of cortical volume change was total antipsychotic dose received (p = 0.04). Cortical volume change was not significantly associated with the changes in psychopathology, functionality, extrapyramidal symptoms and body mass index or age, gender and duration of untreated psychosis.ConclusionsBrain volume reductions associated with antipsychotic treatment are not restricted to poor outcome patients and occur even with the lowest effective dose of antipsychotic. The lack of an association with poor treatment response or treatment-related adverse effects counts against cortical volume reductions reflecting neurotoxicity, at least in the short term. On the other hand, the volume reductions were not linked to the therapeutic benefits of antipsychotics.

Relationship between white matter T2 hyperintensity and cortical volume changes on magnetic resonance imaging in healthy elders

2010 ◽  
Vol 26 (9) ◽  
pp. 886-892 ◽  
Author(s):  
Miho Ota ◽  
Kiyotaka Nemoto ◽  
Noriko Sato ◽  
Katsutoshi Mizukami ◽  
Fumio Yamashita ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Volume Changes ◽  
Cortical Volume ◽  
T2 Hyperintensity

Volume changes in HgTe upon melting and heating

1997 ◽  
Vol 94 ◽  
pp. 1816-1826 ◽  
Author(s):  
M Glazov ◽  
LM Pavlova ◽  
SV Stankus
Keyword(s):  
Volume Changes

Hippocampal and amygdala volume changes in patients with major depression and healthy controls during a three year follow-up

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
TS Frodl ◽  
T Zetzsche ◽  
G Schmitt ◽  
T Schlossbauer ◽  
MW Jäger ◽  
...  
Keyword(s):  
Major Depression ◽  
Healthy Controls ◽  
Volume Changes ◽  
Amygdala Volume
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