HSV-1-Specific IgG Subclasses Distribution and Serum Neutralizing Activity in Alzheimer’s Disease and in Mild Cognitive Impairment

2018 ◽  
Vol 63 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Simone Agostini ◽  
Roberta Mancuso ◽  
Ambra Hernis ◽  
Andrea Saul Costa ◽  
Raffaello Nemni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Igg Subclasses ◽  
Neutralizing Activity ◽  
Specific Igg ◽  
Hsv 1

P4-105: HSV-1 Specific IGG Subclasses in Individuals with Alzheimer’s Disease

2016 ◽  
Vol 12 ◽  
pp. P1052-P1053 ◽  
Author(s):  
Roberta Mancuso ◽  
Simone Agostini ◽  
Elena Calabrese ◽  
Ambra Hernis ◽  
Raffaello Nemni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Igg Subclasses ◽  
Specific Igg ◽  
Hsv 1

P4-104: HSV-1 Avidity Index: A Possible Biomarker for Monitoring the Evolution of Mild Cognitive Impairment to Alzheimer’s Disease

2016 ◽  
Vol 12 ◽  
pp. P1052-P1052
Author(s):  
Simone Agostini ◽  
Roberta Mancuso ◽  
Elena Calabrese ◽  
Ambra Hernis ◽  
Raffaello Nemni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Avidity Index ◽  
Hsv 1

scholarly journals HSV-1-Specific IgG3 Titers Correlate with Brain Cortical Thinning in Individuals with Mild Cognitive Impairment and Alzheimer’s Disease

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 255 ◽  
Author(s):  
Roberta Mancuso ◽  
Monia Cabinio ◽  
Simone Agostini ◽  
Francesca Baglio ◽  
Mario Clerici
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune Response ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Viral Reactivation ◽  
Immune Recognition ◽  
Humoral Immune ◽  
Simplex Virus ◽  
Hsv 1

Repeated reactivations of latent herpes simplex virus type-1 (HSV-1) in the central nervous system (CNS) may contribute to neurodegeneration in Alzheimer’s disease (AD) patients. Immune response is a key element for the control of viral reactivation. HSV-1 uses a number of strategies to evade immune recognition, Immunoglobulin G 3 (IgG3) alone counteracts humoral immunoevasion, as it is the only IgG subclass that is not blocked by the HSV-1 Fc receptor, a protein that protects virion and infected cells from antibody-mediated effector mechanisms. We examined HSV-1-specific IgG3 titers in serum of AD (n = 70) and mild cognitive impairment (MCI) (n = 61) subjects comparing the results to those of 67 age- and sex-matched healthy controls (HC); associations between MRI-determined brain cortical health and HSV-1-specific IgG3 were analyzed in a subgroup of AD and MCI subjects. HSV-1-specific IgG3 were more frequently detected in MCI compared to AD and HC subjects. Significant inverse correlations were found between IgG3 titers and brain cortical thickness in areas typically involved in dementia and HSV-1 encephalitis in AD patients; interestingly, this negative correlation was much less important in MCI subjects. All together these results suggest that in AD an inefficient IgG3 humoral immune response, failing to block viral replication, contributes to progressive neurodegeneration.

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