scholarly journals Added Diagnostic Value of Cerebrospinal Fluid Biomarkers for Differential Dementia Diagnosis in an Autopsy-Confirmed Cohort

2018 ◽  
Vol 63 (1) ◽  
pp. 373-381 ◽  
Author(s):  
Ellis Niemantsverdriet ◽  
Bart F.E. Feyen ◽  
Nathalie Le Bastard ◽  
Jean-Jacques Martin ◽  
Johan Goeman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Diagnostic Value ◽  
Dementia Diagnosis ◽  
Cerebrospinal Fluid Biomarkers

scholarly journals Cerebrospinal fluid biomarkers and apolipoprotein E genotype in cerebral amyloid angiopathy. A narrative review

2021 ◽  
Vol 2 ◽  
pp. 100010
Author(s):  
Aikaterini Theodorou ◽  
Ioanna Tsantzali ◽  
Elisabeth Kapaki ◽  
Vasilios C. Constantinides ◽  
Konstantinos Voumvourakis ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Apolipoprotein E ◽  
Cerebral Amyloid Angiopathy ◽  
Narrative Review ◽  
Amyloid Angiopathy ◽  
Cerebrospinal Fluid Biomarkers ◽  
Cerebral Amyloid ◽  
Apolipoprotein E Genotype

scholarly journals Unique Sleep and Circadian Rhythm Dysfunction Neuroinflammatory and Immune Profiles in Alzheimer’s Disease with Mild Cognitive Impairment

2021 ◽  
pp. 1-6
Author(s):  
Jagan A. Pillai ◽  
James Bena ◽  
Lynn M. Bekris ◽  
Nancy Foldvary-Schaefer ◽  
Catherine Heinzinger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Circadian Rhythm ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Cerebrospinal Fluid Biomarkers ◽  
Circulating Markers

Sleep dysfunction has been identified in the pathophysiology of Alzheimer’s disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood. In a well-characterized cohort of patients with AD at the mild cognitive impairment stage (MCI-AD), we identify that circadian rhythm irregularities were accompanied by altered humoral immune responses detected in both the cerebrospinal fluid and plasma as well as alterations of cerebrospinal fluid biomarkers of neurodegeneration. On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.

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