Mesenchymal Stem Cell-Derived Extracellular Vesicles Suppresses iNOS Expression and Ameliorates Neural Impairment in Alzheimer’s Disease Mice

2018 ◽  
Vol 61 (3) ◽  
pp. 1005-1013 ◽  
Author(s):  
Shan-Shan Wang ◽  
Jianjun Jia ◽  
Zhenfu Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Inos Expression ◽  
Neural Impairment

scholarly journals Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

Theranostics ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 8129-8142
Author(s):  
Allaura S. Cone ◽  
Xuegang Yuan ◽  
Li Sun ◽  
Leanne C. Duke ◽  
Michael P. Vreones ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Mouse Model ◽  
Extracellular Vesicles

scholarly journals Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer’s disease

2017 ◽  
Vol 29 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Lee Chuen Liew ◽  
Takeshi Katsuda ◽  
Luc Gailhouste ◽  
Hitoshi Nakagama ◽  
Takahiro Ochiya
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles

scholarly journals Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease

2019 ◽  
Vol 14 (9) ◽  
pp. 1626 ◽  
Author(s):  
AlejandroA Canales-Aguirre ◽  
EdwinE Reza-Zaldivar ◽  
MercedesA Hernández-Sapiéns ◽  
YanetK Gutiérrez-Mercado ◽  
Sergio Sandoval-Ávila ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cognitive Function ◽  
Mesenchymal Stem Cell ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Function Recovery

scholarly journals Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mengtian Guo ◽  
Zhenyu Yin ◽  
Fanglian Chen ◽  
Ping Lei
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Tumor Formation ◽  
Promising Alternative ◽  
Derived Properties ◽  
Delivery Vehicles ◽  
Primary Focus ◽  
Global Aging

AbstractAlzheimer’s disease (AD) has been a devastating public health with the development of global aging. Approaches for reducing the current AD epidemic are becoming a primary focus of human healthcare due to the lack of achieved lasting and complete remission strategies to treat AD with the characteristics of heterogeneity and complexity. Exosomes, which is the new emerging approach to intercellular communication, provide novel perspective on identified therapeutic strategies of AD. Mesenchymal stem cell-derived exosomes (MSC-exos) are emerging to be an appealing therapeutic tool for AD, with the donor-derived properties and the characteristics of minimal immunogenicity, effortless storage, nature delivery vehicles, and low risks of tumor formation based on the previous researches. In this review, we elaborate the mechanism of MSC-exos in the treatment of AD and discuss limitations in the clinical application.

scholarly journals Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 594
Author(s):  
Yi-An Chen ◽  
Cheng-Hsiu Lu ◽  
Chien-Chih Ke ◽  
Sain-Jhih Chiu ◽  
Fong-Shya Jeng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Synaptic Plasticity ◽  
Mesenchymal Stem Cell ◽  
Cell Model ◽  
Neuronal Loss ◽  
18F Fdg ◽  
The Brain

The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to Alzheimer’s disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal therapies should tackle the core AD pathophysiology and prevent the decline in memory and cognitive functions. This study aimed to evaluate the therapeutic performance of mesenchymal stem cell-derived exosomes (MSC-exosomes), which are secreted membranous elements encapsulating a variety of MSC factors, on AD. A human neural cell culture model with familial AD (FAD) mutations was established and co-cultured with purified MSC-exosomes. 2-[18F]Fluoro-2-deoxy-d-glucose ([18F]FDG) and novel object recognition (NOR) testing were performed before/after treatment to evaluate the therapeutic effect in vivo. The AD-related pathology and the expression of neuronal memory/synaptic plasticity-related genes were also evaluated. The results showed that MSC-exosomes reduced Aβ expression and restored the expression of neuronal memory/synaptic plasticity-related genes in the cell model. [18F]FDG-PET imaging and cognitive assessment revealed a significant improvement in brain glucose metabolism and cognitive function in AD transgenic mice. The phase of neurons and astrocytes in the brain of AD mice were also found to be regulated after treatment with MSC-exosomes. Our study demonstrates the therapeutic mechanism of MSC-exosomes and provides an alternative therapeutic strategy based on cell-free MSC-exosomes for the treatment of AD.

scholarly journals Mitigation of Alzheimer’s Disease Neuropathologies by Human Neural Stem Cell-derived Extracellular Vesicles

2020 ◽  
Author(s):  
Lauren A Apodaca ◽  
Al Anoud D Baddour ◽  
Camilo Garcia ◽  
Leila Alikhani ◽  
Erich Giedzinski ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Extracellular Vesicles ◽  
Age Groups ◽  
Synaptic Function ◽  
Neuroprotective Effects ◽  
Partial Restoration ◽  
Human Neural Stem Cell

Abstract Background: Regenerative therapies to mitigate Alzheimer’s disease (AD) neuropathology have shown very limited success. In the recent era, extracellular vesicles (EV) derived from multipotent and pluripotent stem cells have shown considerable promise for the treatment of dementia and many neurodegenerative conditions. Methods: Using the 5xFAD accelerated transgenic mouse model of AD, we now show the regenerative potential of human neural stem cell (hNSC)-derived EV on the neurocognitive and neuropathologic outcomes in the AD brain. Two or six-month-old 5xFAD mice received single or two intra-venous (retro-orbital vein, RO) injections of hNSC-derived EV, respectively.Results: RO treatment using hNSC-derived EV restored fear extinction memory consolidation and reduced anxiety-related behaviors 4-6 weeks post-injection. EV treatment also significantly reduced dense core amyloid-beta plaque accumulation and microglial activation in both age groups. These results correlated with partial restoration of homeostatic levels of circulating pro-inflammatory cytokines in the AD mice. Importantly, EV treatment protected against synaptic loss in the AD brain that paralleled improved cognition. MiRNA analysis of the EV cargo revealed promising candidates targeting neuroinflammation and synaptic function. Conclusions: Collectively, these data demonstrate the neuroprotective effects of systemic administration of stem cell-derived EV for remediation of behavioral and molecular AD neuropathologies.

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