Effects of Physical Exercise on Alzheimer’s Disease Biomarkers: A Systematic Review of Intervention Studies

2017 ◽  
Vol 61 (1) ◽  
pp. 359-372 ◽  
Author(s):  
Kristian Steen Frederiksen ◽  
Le Gjerum ◽  
Gunhild Waldemar ◽  
Steen Gregers Hasselbalch
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Exercise ◽  
Intervention Studies ◽  
Disease Biomarkers

scholarly journals A Systematic Review of Longitudinal Studies Which Measure Alzheimer’s Disease Biomarkers

2017 ◽  
Vol 59 (4) ◽  
pp. 1359-1379 ◽  
Author(s):  
Emma Lawrence ◽  
Carolin Vegvari ◽  
Alison Ower ◽  
Christoforos Hadjichrysanthou ◽  
Frank De Wolf ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Studies ◽  
Disease Biomarkers

Proteomics as a reliable approach for discovery of blood-based Alzheimer’s disease biomarkers: A systematic review and meta-analysis

2020 ◽  
Vol 60 ◽  
pp. 101066 ◽  
Author(s):  
Siti Hajar Rehiman ◽  
Siong Meng Lim ◽  
Chin Fen Neoh ◽  
Abu Bakar Abdul Majeed ◽  
Ai-Vyrn Chin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Disease Biomarkers

scholarly journals Physical exercise is effective for neuropsychiatric symptoms in Alzheimer's disease: a systematic review

2021 ◽  
Vol 79 (5) ◽  
pp. 447-456
Author(s):  
Dayanne Christine Borges Mendonça ◽  
Denise Rodrigues Fernandes ◽  
Salma Soleman Hernandez ◽  
Fernando Diákson Gontijo Soares ◽  
Karina de Figueiredo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Exercise ◽  
Elderly People ◽  
Longitudinal Research ◽  
Neuropsychiatric Symptoms ◽  
Functional Decline ◽  
Eligibility Criteria ◽  
Positive Effect

ABSTRACT Background: Neuropsychiatric symptoms are disorders frequently seen in Alzheimer's disease. These symptoms contribute to reduction of brain reserve capacity and, in addition, they present unfavorable implications, such as: poor prognosis for the disease, increased functional decline, increased burden on the caregiver and institutionalization. This scenario makes neuropsychiatric symptoms one of the biggest problems in Alzheimer's disease, and gives rise to a need for treatments focused on improving these symptoms. Sow progress in drug trials has led to interest in exploring non-pharmacological measures for improving the neuropsychiatric symptoms of Alzheimer's disease, such as physical exercise. Objective: To ascertain the effect of exercise on the neuropsychiatric symptoms of Alzheimer's disease and its implications. Methods: This was a systematic review of effective longitudinal research, conducted by searching for articles in the PubMed, Web of Science, CINAHL and Scopus electronic databases, from 2009 to 2019. Studies in which the sample consisted of elderly people aged 65 years old or over with a diagnosis of Alzheimer's disease were included. Initially 334 articles were identified. After exclusions, 21 articles remained to be read in full. From these, five articles fitted the eligibility criteria, and a further two articles were added through manual searches in the references of the articles found. Results: Out of the seven articles analyzed in this review, five studies revealed that physical exercise had a positive effect on the neuropsychiatric symptoms of Alzheimer's disease. Conclusion: This systematic review indicated that physical exercise is a favorable non-pharmacological means for attenuating the neuropsychiatric symptoms of elderly people with Alzheimer's disease, with special attention to aerobic exercises.

Physical exercise protocols in animal models of Alzheimer’s disease: a systematic review

2020 ◽  
Vol 36 (1) ◽  
pp. 85-95 ◽  
Author(s):  
Ricardo Augusto Leoni De Sousa ◽  
Cíntia Maria Rodrigues ◽  
Bruno Ferreira Mendes ◽  
Alex Cleber Improta-Caria ◽  
Marco Fabrício Dias Peixoto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Physical Exercise

scholarly journals Impact of physical exercise on quality of life of older adults with depression or Alzheimer's disease: a systematic review

2014 ◽  
Vol 36 (3) ◽  
pp. 134-139 ◽  
Author(s):  
Bianca Boscarino Tavares ◽  
Helena Moraes ◽  
Andrea Camaz Deslandes ◽  
Jerson Laks
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Exercise ◽  
The Elderly ◽  
Pharmacological Intervention ◽  
Older Individuals ◽  
Control Groups

INTRODUCTION: Physical exercise has been associated with improvement of quality of live (QoL), but its effect among the elderly with depression and Alzheimer's disease (AD) is still unclear. This systematic review evaluated randomized and controlled studies about the effect of physical exercise on QoL of older individuals with a clinical diagnosis of depression and AD.METHODS:We searched PubMed, ISI, SciELO and Scopus from December 2011 to June 2013 using the following keywords: physical exercise, quality of life, elderly, depression, Alzheimer's disease. Only six studies met inclusion criteria: two examined patients with AD and four, patients with depression.RESULTS: The studies used different methods to prescribe exercise and evaluate QoL, but all had high quality methods. Findings of most studies with individuals with depression suggested that exercise training improved QoL, but studies with patients with AD had divergent results.CONCLUSIONS: Although different methods were used, results suggested that physical exercise is an effective non-pharmacological intervention to improve the QoL of elderly individuals with depression and AD. Future studies should investigate the effect of other factors, such as the use of specific scales for the elderly, controlled exercise prescriptions and type of control groups.

Neuroprotective mechanisms of chronic physical exercise via reduction of β-amyloid protein in experimental models of Alzheimer's disease: A systematic review

Life Sciences ◽  
2021 ◽  
Vol 275 ◽  
pp. 119372
Author(s):  
Francisco Sérgio Lopes Vasconcelos-Filho ◽  
Lucas Christyan da Rocha Oliveira ◽  
Tereza Brenda Clementino de Freitas ◽  
Pedro Alberto Diógenes Saldanha de Pontes ◽  
Roberta Cristina da Rocha-e-Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Exercise ◽  
Experimental Models ◽  
Amyloid Protein ◽  
Β Amyloid

Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: Systematic review and meta-analysis

2021 ◽  
pp. 111502
Author(s):  
Francisco Sérgio Lopes Vasconcelos-Filho ◽  
Lucas Christyan da Rocha Oliveira ◽  
Tereza Brenda Clementino de Freitas ◽  
Pedro Alberto Diógenes Saldanha de Pontes ◽  
Roberta Cristina da Rocha-e-Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Exercise ◽  
Meta Analysis ◽  
Beta Amyloid ◽  
Experimental Models ◽  
Amyloid Protein ◽  
Beta Amyloid Protein
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