Serotonin Selective Reuptake Inhibitor Treatment Improves Cognition and Grey Matter Atrophy but not Amyloid Burden During Two-Year Follow-Up in Mild Cognitive Impairment and Alzheimer’s Disease Patients with Depressive Symptoms

2018 ◽  
Vol 65 (3) ◽  
pp. 793-806 ◽  
Author(s):  
Matthias Brendel ◽  
Julia Sauerbeck ◽  
Sonja Greven ◽  
Sebastian Kotz ◽  
Franziska Scheiwein ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Mild Cognitive Impairment ◽  
Reuptake Inhibitor ◽  
Grey Matter ◽  
Amyloid Burden ◽  
Grey Matter Atrophy ◽  
Serotonin Selective Reuptake Inhibitor ◽  
Inhibitor Treatment

Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment

2018 ◽  
Vol 66 (2) ◽  
pp. 533-549 ◽  
Author(s):  
Ashwati Vipin ◽  
Heidi Jing Ling Foo ◽  
Joseph Kai Wei Lim ◽  
Russell Jude Chander ◽  
Ting Ting Yong ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Grey Matter ◽  
White Matter Hyperintensity ◽  
Grey Matter Atrophy

Relation between subcortical grey matter atrophy and conversion from mild cognitive impairment to Alzheimer's disease

2015 ◽  
Vol 87 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Hyon-Ah Yi ◽  
Christiane Möller ◽  
Nikki Dieleman ◽  
Femke H Bouwman ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Grey Matter ◽  
Grey Matter Atrophy

Grey Matter Atrophy Associated With Delusional Onset In Mild Cognitive Impairment Patients

2014 ◽  
Vol 22 (3) ◽  
pp. S132-S133
Author(s):  
Corinne E. Fischer ◽  
Windsor K. Ting ◽  
Colleen Millikin ◽  
Zahinoor Ismail ◽  
Tom Schweizer
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Grey Matter ◽  
Grey Matter Atrophy

Grey matter atrophy of basal forebrain and hippocampus in mild cognitive impairment

2010 ◽  
Vol 82 (5) ◽  
pp. 487-493 ◽  
Author(s):  
H. Zhang ◽  
J. N. Trollor ◽  
W. Wen ◽  
W. Zhu ◽  
J. D. Crawford ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Basal Forebrain ◽  
Grey Matter ◽  
Grey Matter Atrophy

scholarly journals P3-301: MILD COGNITIVE IMPAIRMENT STAGING YIELDS BIOMARKER DIFFERENCES, LONGITUDINAL COGNITIVE DECLINE, AND GREY MATTER ATROPHY

2019 ◽  
Vol 15 ◽  
pp. P1052-P1052
Author(s):  
Elizabeth E. Moore ◽  
Dandan Liu ◽  
Kimberly R. Pechman ◽  
Lealani Mae Y. Acosta ◽  
Susan P. Bell ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Grey Matter ◽  
Grey Matter Atrophy

scholarly journals Are depressive symptoms in mild cognitive impairment predictive of conversion to dementia?

2016 ◽  
Vol 28 (6) ◽  
pp. 921-928 ◽  
Author(s):  
Ellen De Roeck ◽  
Ingrid Ponjaert-Kristoffersen ◽  
Marc Bosmans ◽  
Peter Paul De Deyn ◽  
Sebastiaan Engelborghs ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Mild Cognitive Impairment ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Cued Recall ◽  
Cognitive Testing ◽  
Cognitive Measures ◽  
Significant Difference

ABSTRACTBackground:Depressive symptoms are common in amnestic mild cognitive impairment (aMCI). The association between depressive symptoms and conversion to dementia is not yet clear. This longitudinal study was conducted to ascertain whether depressive symptoms in aMCI patients are predictive of conversion to dementia.Methods:35 aMCI patients participated in this study. All participants underwent cognitive testing and were administered the geriatric depression scale (GDS) to determine the presence of depressive symptoms. A score equaling or higher than 11 on the GDS was taken as the cut-off point for presence of significant depressive symptoms. Conversion to dementia was assessed at follow-up visits after 1.5, 4, and 10 years.Results:31.4% of the patients reported depressive symptoms at baseline. None of the cognitive measures revealed a significant difference at baseline between patients with and without depressive symptoms. After 1.5, 4, and 10 years respectively 6, 14, and 23 patients had converted to dementia. Although the GDS scores at baseline did not predict conversion to dementia, the cognitive measures and more specifically a verbal cued recall task (the memory impairment scale-plus) was a good predictor for conversion.Conclusions:Based on this dataset, the presence of depressive symptoms in aMCI patients is not predictive of conversion to dementia.

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