scholarly journals Identification of Successful Cognitive Aging in the Alzheimer’s Disease Neuroimaging Initiative Study

2017 ◽  
Vol 59 (1) ◽  
pp. 101-111 ◽  
Author(s):  
Feng V. Lin ◽  
Xixi Wang ◽  
Rachel Wu ◽  
George W. Rebok ◽  
Benjamin P. Chapman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Aging

ARMADA: Assessing reliable measurement in Alzheimer’s disease and cognitive aging project methods

2021 ◽  
Author(s):  
Sandra Weintraub ◽  
Tatiana Karpouzian‐Rogers ◽  
John Devin Peipert ◽  
Cindy Nowinski ◽  
Jerry Slotkin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Aging ◽  
Reliable Measurement

Structural MRI in Alzheimer’s Disease

2020 ◽  
pp. 208-240
Author(s):  
Briana S. Last ◽  
Batool Rizvi ◽  
Adam M. Brickman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrovascular Disease ◽  
Cognitive Aging ◽  
Structural Mri ◽  
The Other ◽  
Aging Brain ◽  
Medial Temporal Lobes ◽  
Temporal Lobes ◽  
Magnetic Resonance Imaging Mri

Structural magnetic resonance imaging (MRI) is a powerful tool to visualize and quantitate morphological and pathological features of the aging brain. Most work that has used structural MRI to study Alzheimer’s disease (AD) focused on the spatial distribution of atrophic changes associated with disease. These studies consistently show focal atrophy beginning in medial temporal lobes in early and presymptomatic stages of AD before spreading globally throughout the cortical mantle. Normal cognitive aging—aging in the absence of major neurodegenerative disease—on the other hand follows and anterior-to-posterior gradient of atrophic change. In addition to atrophic changes, conventional structural MRI can be used to appreciate markers of small and large vessel cerebrovascular disease, including white matter hyperintensities (WMHs), cerebral microbleeds, and infarction. Studies that have examined cerebrovascular changes associated with AD also show a consistent relationship with risk and severity of clinical AD, particularly with regard to lobar microbleeds and posterior WMH. It is unclear whether cerebrovascular changes play an independent role in the clinical expression of AD or whether it is more mechanistically related, reflecting a core feature of the disease. This chapter reviews recent work on regional atrophy in AD and normal aging, as well as work on small and large cerebrovascular disease in AD.

Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys

2020 ◽  
pp. 303-334
Author(s):  
Johanna L. Crimins ◽  
Yuko Hara ◽  
John H. Morrison
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Aging ◽  
Rhesus Monkeys ◽  
Memory Systems ◽  
Brain Regions ◽  
Clinical Literature ◽  
Menopausal Women ◽  
Dorsolateral Prefrontal ◽  
Estrogenic Regulation

A compelling case can be made for estrogen’s role in maintaining synaptic health in the context of cognitive aging. This chapter first reviews clinical literature pertinent to estrogenic actions on cognition in menopausal women. Next, the authors provide a comprehensive summary of recent investigations in aging rhesus monkeys, which have emerged as a particularly powerful model for the study of synaptic and cognitive effects of both natural and surgical menopause. In particular, we focus on hippocampal and dorsolateral prefrontal cortex neurons and circuits that degenerate in normal aging and Alzheimer’s disease. The responsiveness of these brain regions to estrogen and implications for their related memory systems are discussed. Finally, the chapter highlights work that needs to be done to more fully understand the molecular basis for the complex interplay between menopause, aging, and vulnerability to Alzheimer’s disease in higher cognitive function and synaptic health.

scholarly journals APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease

2020 ◽  
Vol 87 ◽  
pp. 18-25 ◽  
Author(s):  
Annah M. Moore ◽  
Emily Mahoney ◽  
Logan Dumitrescu ◽  
Philip L. De Jager ◽  
Mary Ellen I. Koran ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Family ◽  
Cognitive Aging ◽  
Vegf Gene ◽  
Apoe Ε4

scholarly journals Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

2014 ◽  
Vol 39 (3) ◽  
pp. 565-574 ◽  
Author(s):  
Sarah E. Harris ◽  
Gail Davies ◽  
Michelle Luciano ◽  
Antony Payton ◽  
Helen C. Fox ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Older People ◽  
Cognitive Ability ◽  
Cognitive Aging ◽  
Polygenic Risk
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