A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study

2017 ◽  
Vol 56 (4) ◽  
pp. 1459-1468 ◽  
Author(s):  
Christian-Alexandre Castellano ◽  
Nancy Paquet ◽  
Isabelle J. Dionne ◽  
Hélène Imbeault ◽  
Francis Langlois ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
Training Program ◽  
Aerobic Training ◽  
Brain Energy Metabolism ◽  
Preliminary Results ◽  
Neuroimaging Study ◽  
Brain Energy

scholarly journals Bibliometric Analysis Study on the Mechanisms of Brain Energy Metabolism Disorders in Alzheimer's Disease From 2000 to 2020

2021 ◽  
Vol 12 ◽  
Author(s):  
Yi-Hong Du ◽  
Ruo-Yu Yang ◽  
Qi Wang ◽  
Li-Yan Wang ◽  
Lei-Chao Liang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
The Elderly ◽  
Brain Energy Metabolism ◽  
Metabolism Disorder ◽  
Pathogenic Factors ◽  
Aβ Amyloid ◽  
Research Frontiers ◽  
Brain Energy

Alzheimer's disease (AD) is currently one of the main diseases afflicting the elderly in the world. In recent years, more and more studies have shown that brain energy metabolism disorders are the key pathogenic factors and main early pathological features of AD. Many risk factors such as insulin resistance, mitochondrial dysfunction, oxidative stress, Aβ-amyloid plaques, neurofibrillary tangles of hyperphosphorylated tau, aging, and neuroinflammation are involved in brain energy metabolism disorders. In this study, 1,379 Web of Science publications on the mechanisms of brain energy metabolism disorders in AD, all published from 2000 to 2020, were analyzed. Some network maps were drawn using CiteSpace and VOSviewer software which can be used to clarify research focus, forecast research frontiers and development trends, and provide different perspectives and characteristics in AD brain energy metabolism disorder mechanisms.

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease

2018 ◽  
Vol 64 (2) ◽  
pp. 551-561 ◽  
Author(s):  
Etienne Croteau ◽  
Christian-Alexandre Castellano ◽  
Marie Anne Richard ◽  
Mélanie Fortier ◽  
Scott Nugent ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Brain Energy

scholarly journals Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging

2016 ◽  
Vol 37 (8) ◽  
pp. 2870-2882 ◽  
Author(s):  
Jatta S Takkinen ◽  
Francisco R López-Picón ◽  
Rana Al Majidi ◽  
Olli Eskola ◽  
Anna Krzyczmonik ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
Pet Imaging ◽  
Ex Vivo ◽  
Underlying Disease ◽  
Brain Energy Metabolism ◽  
Model Of Alzheimer’S Disease ◽  
Brain Energy

Preclinical animal model studies of brain energy metabolism and neuroinflammation in Alzheimer’s disease have produced conflicting results, hampering both the elucidation of the underlying disease mechanism and the development of effective Alzheimer’s disease therapies. Here, we aimed to quantify the relationship between brain energy metabolism and neuroinflammation in the APP/PS1-21 transgenic mouse model of Alzheimer’s disease using longitudinal in vivo18F-FDG and 18F-DPA-714) PET imaging and ex vivo brain autoradiography. APP/PS1-21 (TG, n = 9) and wild type control mice (WT, n = 9) were studied longitudinally every third month from age 6 to 15 months with 18F-FDG and 18F-DPA-714 with a one-week interval between the scans. Additional TG (n = 52) and WT (n = 29) mice were used for ex vivo studies. In vivo, the 18F-FDG SUVs were lower and the 18F-DPA-714 binding ratios relative to the cerebellum were higher in the TG mouse cortex and hippocampus than in WT mice at age 12 to 15 months ( p < 0.05). The ex vivo cerebellum binding ratios supported the results of the in vivo18F-DPA-714 studies but not the 18F-FDG studies. This longitudinal PET study demonstrated decreased energy metabolism and increased inflammation in the brains of APP/PS1-21 mice compared to WT mice.

Modelling of calcium dynamics in brain energy metabolism and Alzheimer's disease

2005 ◽  
Vol 29 (2) ◽  
pp. 151-162 ◽  
Author(s):  
S. Tiveci ◽  
A. Akın ◽  
T. Çakır ◽  
H. Saybaşılı ◽  
K. Ülgen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Calcium Dynamics ◽  
Brain Energy
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