What is the Relationship of Traumatic Brain Injury to Dementia?

2017 ◽  
Vol 57 (3) ◽  
pp. 667-681 ◽  
Author(s):  
Mario F. Mendez
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Relationship Of ◽  
The Relationship

scholarly journals The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury

2018 ◽  
Vol 20 (5) ◽  
pp. 566-576 ◽  
Author(s):  
Karin Reuter-Rice ◽  
Michael Regier ◽  
Ellen Bennett ◽  
Daniel Laskowitz
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerebral Vasospasm ◽  
Functional Outcomes ◽  
Injury Severity ◽  
Apoe Genotype ◽  
Apoe Gene ◽  
Nucleotide Polymorphisms ◽  
Relationship Of ◽  
The Relationship

Background: Pediatric traumatic brain injury (TBI) is a leading cause of death and disability. Polymorphisms in the apolipoprotein E ( APOE) gene have been linked to cerebral vasospasm (CV) and poor outcomes in adults with TBI, yet these associations remain poorly defined in children. Objective: We examined the effect of the relationship between APOE polymorphisms and CV on functional outcomes in children with a TBI. Method: This prospective, descriptive study examined 60 children (aged 10 days to 15 years) with a TBI. Data included demographic information, genetic sampling for the APOE gene and single-nucleotide polymorphisms (SNPs; rs405509, rs429358, rs7412), and daily transcranial Doppler ultrasounds to evaluate for CV. We examined Glasgow Outcome Scale–Extended Pediatrics (GOS-E Peds) scores at the time of discharge and 4–6 weeks after discharge. Results: More than half (56.7%) of the 60 children ( Mage = 5.9 years) were male. Twenty-six participants (43.3%) experienced an occurrence of CV. There were significant differences in injury mechanism (unadjusted p = .048) and age (unadjusted p = .02) between those with and without CV. Also, the noncoding promoter SNP rs405509 T/T, when considered with injury severity, appeared to modify the relationship of APOE genotype to CV. The relationship between APOE and CV had no significant effect on GOS-E Peds scores. Conclusion: Injury severity and the APOE noncoding promoter SNP rs405509 may modify the relationship between APOE and CV in children with TBI. More studies are needed to understand the role of APOE polymorphisms in outcomes in children with TBI.

scholarly journals The relationship of parental warm responsiveness and negativity to emerging behavior problems following traumatic brain injury in young children.

2011 ◽  
Vol 47 (1) ◽  
pp. 119-133 ◽  
Author(s):  
Shari L. Wade ◽  
Amy Cassedy ◽  
Nicolay C. Walz ◽  
H. Gerry Taylor ◽  
Terry Stancin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Children ◽  
Behavior Problems ◽  
Relationship Of ◽  
The Relationship

The relationship of neuropsychological status and productive outcomes following traumatic brain injury

Brain Injury ◽  
1996 ◽  
Vol 10 (9) ◽  
pp. 663-676 ◽  
Author(s):  
D. GIRARD ◽  
J. BROWN ◽  
M. BURNETT-STOLNACK ◽  
N. HASHIMOTO ◽  
S. HIER-WELLMER ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neuropsychological Status ◽  
Relationship Of ◽  
The Relationship

scholarly journals Traumatic brain injury may not increase the risk of Alzheimer disease

Neurology ◽  
2017 ◽  
Vol 89 (18) ◽  
pp. 1923-1925 ◽  
Author(s):  
Michael W. Weiner ◽  
Paul K. Crane ◽  
Thomas J. Montine ◽  
David A. Bennett ◽  
Dallas P. Veitch
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Alzheimer Disease ◽  
Epidemiologic Studies ◽  
Increased Risk ◽  
Military Populations ◽  
Long Term Consequences ◽  
Relationship Of ◽  
The Relationship

Traumatic brain injury (TBI) commonly occurs in civilian and military populations. Some epidemiologic studies previously have associated TBI with an increased risk of Alzheimer disease (AD). Recent clinicopathologic and biomarker studies have failed to confirm the relationship of TBI to the development of AD dementia or pathologic changes, and suggest that other neurodegenerative processes might be linked to TBI. Additional studies are required to determine the long-term consequences of TBI.

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