Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer’s Disease

2016 ◽  
Vol 55 (4) ◽  
pp. 1595-1603 ◽  
Author(s):  
Andrea Slachevsky ◽  
Leonardo Guzmán-Martínez ◽  
Carolina Delgado ◽  
Pablo Reyes ◽  
Gonzalo A. Farías ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Regional Brain ◽  
Regional Brain Atrophy

P3-112: Patterns of regional brain atrophy and amyloid deposition in Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P593-P593
Author(s):  
Ranjan Duara ◽  
Warren Barker ◽  
David Loewenstein ◽  
Qian Shen ◽  
Maria Greig-Custo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Amyloid Deposition ◽  
Regional Brain ◽  
Regional Brain Atrophy

Regional Brain Atrophy in Patients With Mild Alzheimer's Disease and Delusions

2002 ◽  
Vol 14 (4) ◽  
pp. 365-378 ◽  
Author(s):  
Cristina Geroldi ◽  
Lorena Bresciani ◽  
Orazio Zanetti ◽  
Giovanni B. Frisoni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Repeated Measures ◽  
Specific Pattern ◽  
Temporal Asymmetry ◽  
Model Interaction ◽  
Regional Brain ◽  
Frontal Horn ◽  
Regional Brain Atrophy

Background and Objective: The pathophysiology and the neurobiology of the behavioral disturbances in Alzheimer's disease (AD) are far from understood. The aim of the study was to assess whether delusional AD patients have a specific pattern of regional brain atrophy. Methods: The setting of the study was the outpatients facility of a memory clinic. Subjects were 41 AD patients with mild dementia severity (Mini-Mental State Exam score of 22 ± 3, range 18 to 27). Delusions were assessed with the pertinent subscale of the UCLA Neuropsychiatric Inventory (NPI). Nondelusional (n = 22) AD and delusional (n = 19) AD were defined on the basis of absence (NPI delusions subscale = 0) or presence (NPI delusions subscale = 1 or higher) of delusions. Thirteen (68%) of the delusional patients had isolated theft delusions, and 6 (32%) had theft associated with another paranoid delusion (of jealousy or persecution). None of the patients had misidentifications or other delusions of nonparanoid content. Temporal lobe and frontal lobe atrophy were assessed with linear measures (radial width of the temporal horn, rWTH, and frontal index, FI) taken from computed tomographic films. Temporal and frontal asymmetries were computed as right/left ratio of the rWTH and FI. Results: AD patients without delusions had symmetrical enlargement of both temporal (8.1 ± 3.9 vs. 8.5 ± 4.5) and frontal horns (35.8 ± 4.8 vs. 35.9 ± 4.6). On the contrary, AD with delusions showed temporal horns larger to the right (9.1 ± 3.3 vs. 7.7 ± 3.1, p = .06) and the frontal horn to the left (35.7 ± 4.3 vs. 37.5 ± 4.2, p = .02). This different pattern was confirmed with a gender-adjusted repeated measures analysis of variance model (interaction term between asymmetry and group: F1,38 = 5.5, p = .03). Discussion: AD patients with delusions are characterized by a specific pattern of frontal and temporal asymmetry of brain atrophy, whereas nondelusional patients are symmetric. Because the asymmetry pattern of the delusional patients is similar to the physiological pattern of asymmetry of individuals without dementia, the data indicate that the absence of theft delusions in the mild stage of AD rather than their presence is associated with an abnormal asymmetry pattern.

Differences in regional brain atrophy in genetic forms of Alzheimer's disease

2006 ◽  
Vol 27 (3) ◽  
pp. 387-393 ◽  
Author(s):  
Gillian C. Gregory ◽  
Virginia Macdonald ◽  
Peter R. Schofield ◽  
Jillian J. Kril ◽  
Glenda M. Halliday
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Regional Brain ◽  
Regional Brain Atrophy

scholarly journals Regional brain atrophy predicts time to conversion to Alzheimer's disease, dependent on baseline volume

2019 ◽  
Vol 83 ◽  
pp. 86-94 ◽  
Author(s):  
Hossein Tabatabaei-Jafari ◽  
Marnie E. Shaw ◽  
Erin Walsh ◽  
Nicolas Cherbuin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Regional Brain ◽  
Regional Brain Atrophy

scholarly journals IC-P-162: RELATIONSHIPS BETWEEN FLORTAUCIPIR TAU BINDING AND REGIONAL BRAIN ATROPHY IN AMYLOID POSITIVE SUBJECTS ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

2019 ◽  
Vol 15 ◽  
pp. P129-P130
Author(s):  
Arnaud Charil ◽  
Adam J. Schwarz ◽  
Sudeepti Southekal ◽  
Vikas Kotari ◽  
Michael Navitsky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Disease Spectrum ◽  
Regional Brain ◽  
Regional Brain Atrophy

Apolipoprotein E  4 and the pattern of regional brain atrophy in Alzheimer's disease

Neurology ◽  
2001 ◽  
Vol 57 (8) ◽  
pp. 1461-1466 ◽  
Author(s):  
M. Hashimoto ◽  
M. Yasuda ◽  
S. Tanimukai ◽  
M. Matsui ◽  
N. Hirono ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Brain Atrophy ◽  
Regional Brain ◽  
Regional Brain Atrophy

scholarly journals A Biomarker for Alzheimer’s Disease Based on Patterns of Regional Brain Atrophy

2020 ◽  
Vol 10 ◽  
Author(s):  
Stefan Frenzel ◽  
Katharina Wittfeld ◽  
Mohamad Habes ◽  
Johanna Klinger-König ◽  
Robin Bülow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Regional Brain ◽  
Regional Brain Atrophy
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