Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis

2016 ◽  
Vol 54 (4) ◽  
pp. 1291-1295 ◽  
Author(s):  
Dimitri Renard ◽  
Audrey Gabelle ◽  
Christophe Hirtz ◽  
Christophe Demattei ◽  
Eric Thouvenot ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Superficial Siderosis ◽  
Disease Biomarkers ◽  
Cortical Superficial Siderosis

scholarly journals Development of a robust and stable mass based spectrometry method for analysis of Alzheimer’s disease biomarkers in human cerebrospinal fluid

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Shannon N. Leslie ◽  
Rashaun Wilson ◽  
Bianca A. Trombetta ◽  
Pia Kivisäkk ◽  
Steven E. Arnold ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Spectrometry Method ◽  
Disease Biomarkers ◽  
Human Cerebrospinal Fluid

scholarly journals Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms

2020 ◽  
Vol 73 (1) ◽  
pp. 135-145
Author(s):  
Mirjana Babić Leko ◽  
Matea Nikolac Perković ◽  
Nataša Klepac ◽  
Dubravka Švob Štrac ◽  
Fran Borovečki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Disease Biomarkers

scholarly journals Recurrent Lobar Hemorrhages and Multiple Cortical Superficial Siderosis in a Patient of Alzheimer's Disease With Homozygous APOE ε2 Allele Presenting Hypobetalipoproteinemia and Pathological Findings of 18F-THK5351 Positron Emission Tomography: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Masaki Ikeda ◽  
Koichi Okamoto ◽  
Keiji Suzuki ◽  
Eriko Takai ◽  
Hiroo Kasahara ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intracerebral Hemorrhage ◽  
Pyramidal Tract ◽  
Emission Tomography ◽  
Superficial Siderosis ◽  
Mao B ◽  
Positron Emission ◽  
The Right ◽  
Cortical Superficial Siderosis

In Alzheimer's disease, the apolipoprotein E gene (APOE) ε2 allele is a protective genetic factor, whereas the APOE ε4 allele is a genetic risk factor. However, both the APOE ε2 and the APOE ε4 alleles are genetic risk factors for lobar intracerebral hemorrhage. The reasons for the high prevalence of lobar intracerebral hemorrhage and the low prevalence of Alzheimer's disease with the APOE ε2 allele remains unknown. Here, we describe the case of a 79-year-old Japanese female with Alzheimer's disease, homozygous for the APOE ε2 allele. This patient presented with recurrent lobar hemorrhages and multiple cortical superficial siderosis. The findings on the 11C-labeled Pittsburgh Compound B-positron emission tomography (PET) were characteristic of Alzheimer's disease. 18F-THK5351 PET revealed that the accumulation of 18F-THK 5351 in the right pyramidal tract at the pontine level, the cerebral peduncle of the midbrain, and the internal capsule, reflecting the lesions of the previous lobar intracerebral hemorrhage in the right frontal lobe. Moreover, 18F-THK5351 accumulated in the bilateral globus pallidum, amygdala, caudate nuclei, and the substantia nigra of the midbrain, which were probably off-target reaction, by binding to monoamine oxidase B (MAO-B). 18F-THK5351 were also detected in the periphery of prior lobar hemorrhages and a cortical subarachnoid hemorrhage, as well as in some, but not all, areas affected by cortical siderosis. Besides, 18F-THK5351 retentions were observed in the bilateral medial temporal cortices and several cortical areas without cerebral amyloid angiopathy or prior hemorrhages, possibly where tau might accumulate. This is the first report of a patient with Alzheimer's disease, carrying homozygous APOE ε2 allele and presenting with recurrent lobar hemorrhages, multiple cortical superficial siderosis, and immunohistochemically vascular amyloid β. The 18F-THK5351 PET findings suggested MAO-B concentrated regions, astroglial activation, Waller degeneration of the pyramidal tract, neuroinflammation due to CAA related hemorrhages, and possible tau accumulation.

Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid

2006 ◽  
Vol 10 (4) ◽  
pp. 399-406 ◽  
Author(s):  
Robert G. Riekse ◽  
Ge Li ◽  
Eric C. Petrie ◽  
James B. Leverenz ◽  
Darcy Vavrek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Disease Biomarkers

scholarly journals Identifying Alzheimer's Disease Biomarkers by Analyzing Fatty Acids in Cerebrospinal Fluid and Urine

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Michael Kwong ◽  
Hannah Chew ◽  
Katherine Castor ◽  
Matthew Cipolla ◽  
Michael Harrington ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Cerebrospinal Fluid ◽  
Disease Biomarkers

scholarly journals The Correlation Study between Plasma Aβ Proteins and Cerebrospinal Fluid Alzheimer's Disease Biomarkers

2016 ◽  
Vol 15 (4) ◽  
pp. 122 ◽  
Author(s):  
Ho Sik Shin ◽  
Seung-Keun Lee ◽  
Saeromi Kim ◽  
Hyung-Jun Kim ◽  
Won Seok Chae ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Correlation Study ◽  
Disease Biomarkers

scholarly journals P4-181: CONNECTING ALZHEIMER'S DISEASE BIOMARKERS IN URINE WITH CEREBROSPINAL FLUID CHEMISTRY AND HIPPOCAMPAL VOLUME

2019 ◽  
Vol 15 ◽  
pp. P1345-P1345
Author(s):  
Katherine Castor ◽  
Kevin King ◽  
Thao Tran ◽  
Helena C. Chui ◽  
Michael G. Harrington ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Hippocampal Volume ◽  
Disease Biomarkers ◽  
Fluid Chemistry
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