Early Cognitive Deficits in Type 2 Diabetes: A Population-Based Study

Objective: To investigate the prevalence and risks factors associated with the presence of significant liver fibrosis in subjects with nonalcoholic fatty liver disease (NAFLD) with and without type 2 diabetes mellitus (T2D). Design and methods: This study was part of a population-based study conducted in the Barcelona metropolitan area among subjects aged 18-75 years old. Secondary causes of steatosis were excluded. Moderate-to-advanced liver fibrosis was defined as a liver stiffness measurement (LSM) ≥ 8.0 kPa assessed by transient elastography. Results: Among 930 subjects with NAFLD, the prevalence of moderate-to-advanced liver fibrosis was higher in subjects with T2D compared those without (30.8% vs. 8.7%). By multivariable analysis, one of the main factors independently associated with increased LSM in subjects with NAFLD was atherogenic dyslipidemia, but only in those with T2D. The percentage of subjects with LSM ≥ 8.0 kPa was higher in subjects with T2D and atherogenic dyslipidemia than in those with T2D without atherogenic dyslipidemia, both for the cut-off point of LSM ≥8.0 kPa (45% vs 24%, p=0.002) and 13 kPa (13% vs 4%, p=0.020). No differences were observed in the prevalence of LSM ≥8.0 kPa regarding glycemic control among NAFLD-diabetic subjects. Conclusions: Factors associated with moderate-to-advanced liver fibrosis in NAFLD are different in subjects with and without T2D. Atherogenic dyslipidemia was associated with the presence of moderate-to-advanced liver fibrosis in T2D with NAFLD but not in non-diabetic subjects. These findings highlight the need for an active search for liver fibrosis in subjects with T2D, NAFLD and atherogenic dyslipidemia.

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Associations between sleep duration and type 2 diabetes in Taiwanese adults: A population-based study

Journal of the Formosan Medical Association ◽

10.1016/j.jfma.2016.01.013 ◽

2016 ◽

Vol 115 (9) ◽

pp. 779-785 ◽

Cited By ~ 8

Author(s):

Chia-Ling Lin ◽

Yu-Hsia Tsai ◽

Mei Chang Yeh

Keyword(s):

Type 2 Diabetes ◽

Sleep Duration ◽

Population Based ◽

Population Based Study

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APPLYING DECISION TREE FOR DETECTION OF A RISK FACTORS FOR TYPE 2 DIABETES: A POPULATION BASED STUDY

Acta healthmedica ◽

10.19082/ah138 ◽

2017 ◽

Vol 2 (1) ◽

pp. 138-138

Author(s):

Maryam Tayefi ◽

Habibollah Esmaeily ◽

Majid Ghayour-Mobarhan ◽

Ali Reza Amirabadi zadeh

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Decision Tree ◽

Population Based ◽

Population Based Study

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Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study

Diabetes Care ◽

10.2337/dc20-2607 ◽

2021 ◽

pp. dc202607

Author(s):

You-jung Choi ◽

Kyung-Do Han ◽

Eue-Keun Choi ◽

Jin-Hyeung Jung ◽

So-Ryoung Lee ◽

...

Keyword(s):

Diabetes Mellitus ◽

Atrial Fibrillation ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Population Based ◽

Newly Diagnosed ◽

Population Based Study ◽

Alcohol Abstinence

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Abstract P057: Clusters of Cardiovascular Risk Factors Predict Incidence of Type 2 Diabetes in Men and Women: A Swedish Population-based Study

Circulation ◽

10.1161/circ.133.suppl_1.p057 ◽

2016 ◽

Vol 133 (suppl_1) ◽

Author(s):

Charlotte A Larsson ◽

Bledar Daka ◽

Margareta I Hellgren ◽

Maria C Eriksson ◽

Lennart Råstam ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Population Based ◽

Population Based Study ◽

Men And Women ◽

Self Rated Health

Introduction: Clusters of metabolic variables and their effects on incidence of type 2 diabetes have been studied previously; however, little is known about the effects on diabetes from risk factor clusters including lifestyle and self-rated health. Hypothesis: We assessed the hypothesis that clusters of common cardiovascular risk factors, including lifestyle and self-rated health, can predict development of type 2 diabetes in men and women, respectively. Methods: In 2002-2005, 2816 men and women, 30-74 years, were randomly selected from two municipalities in southwestern Sweden and assessed with regard to cardiovascular/metabolic risk factors within the Skaraborg Project (76% participation). Participants performed an OGTT, had blood samples drawn, had anthropometric measurements and blood pressure taken, and answered validated questionnaires about e.g. leisure-time physical activity (with four answer alternatives from intensive to sedentary) and self-rated health (with five alternatives from excellent to very poor). Using the same protocol, 1332 participants from the baseline survey where re-examined in 2011-2014. After excluding those with diabetes at baseline, 1268 participants were included in this prospective population-based study. Results: Factor analysis (using varimax rotation) identified significant loadings (≥0.40) on the following three identical factors in men and women: the metabolic factor , comprising HOMA-ir, WHR, systolic blood pressure, and apolipoprotein B-to-A1 ratio; the vitality factor , comprising physical activity and self-rated health; and the addiction factor , comprising smoking and alcohol consumption. After a mean follow-up of 9.7±1.4 years, 76 cases of diabetes were identified; 46 in men and 30 in women. In a logistic regression analysis adjusted for all principal components, age, and educational level, the metabolic factor significantly predicted type 2 diabetes in both men (OR: 3.3, CI: 2.3-5.0) and women (OR: 3.5, CI: 2.2-5.6). Furthermore, a predictive effect of the vitality factor was also seen in women (OR: 1.8, CI: 1.2-2.9), but not in men (OR: 1.1, CI: 0.8-1.6), whereas the addiction factor had no effect in either men or women. Conclusions: This is to our knowledge the first time principle components of cardiovascular risk factors, including both metabolic and lifestyle variables, have been used to predict incidence of type 2 diabetes. The gender difference observed with regard to the combined impact of self-rated health and physical activity are novel and indicates a mechanism beside the metabolic syndrome that warrants further gender-specific exploration in future studies.

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