scholarly journals Cerebrospinal Fluid Markers of Alzheimer’s Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer’s Disease

2016 ◽  
Vol 50 (3) ◽  
pp. 873-886 ◽  
Author(s):  
Kelsey E. Melah ◽  
Sharon Yuan-Fu Lu ◽  
Siobhan M. Hoscheidt ◽  
Andrew L. Alexander ◽  
Nagesh Adluru ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
Microglial Activation ◽  
White Matter Microstructure

scholarly journals CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e37720 ◽  
Author(s):  
Barbara B. Bendlin ◽  
Cynthia M. Carlsson ◽  
Sterling C. Johnson ◽  
Henrik Zetterberg ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
White Matter ◽  
Healthy Adults ◽  
White Matter Microstructure ◽  
T Tau

scholarly journals Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer’s disease

2020 ◽  
Author(s):  
Alexa Pichet Binette ◽  
Guillaume Theaud ◽  
François Rheault ◽  
Maggie Roy ◽  
D. Louis Collins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
White Matter ◽  
Free Water ◽  
Brain Regions ◽  
Tau Proteins ◽  
Uncinate Fasciculus ◽  
Preclinical Ad ◽  
White Matter Microstructure

AbstractBeta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer’s disease (AD), are believed to spread through connected regions. Combining diffusion imaging and positron emission tomography, we investigated associations between Aβ, tau and white matter microstructure specifically in bundles connecting brain regions in which AD pathology accumulates. In 126 cognitively normal elderly at risk of AD, we focussed on free-water corrected diffusion measures in the cingulum, posterior cingulum, fornix and uncinate fasciculus. We found higher tissue fractional anisotropy and lower mean and radial diffusivity related to increased Aβ at the cortical endpoints of the cingulum and fornix. We observed similar but stronger associations in the uncinate fasciculus, but with increased Aβ and tau at the endpoints of this bundle. This consistent pattern of associations, with opposite directionality to the usual degeneration pattern in symptomatic individuals, suggests more restricted diffusion in bundles vulnerable to preclinical AD pathology.

scholarly journals White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults

2014 ◽  
Vol 35 (10) ◽  
pp. 2263-2271 ◽  
Author(s):  
Brian T. Gold ◽  
Zude Zhu ◽  
Christopher A. Brown ◽  
Anders H. Andersen ◽  
Mary Jo LaDu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
White Matter Integrity ◽  
Normal Adults

Cerebrospinal fluid β-amyloid1–42 and tau in control subjects at risk for Alzheimer’s disease: The effect of APOE ε4 allele

2004 ◽  
Vol 56 (9) ◽  
pp. 670-676 ◽  
Author(s):  
Trey Sunderland ◽  
Nadeem Mirza ◽  
Karen T. Putnam ◽  
Gary Linker ◽  
Deepa Bhupali ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cerebrospinal Fluid ◽  
Control Subjects ◽  
Apoe Ε4 ◽  
Ε4 Allele

P2-087: PATTERNS OF [C-11]PIB AMYLOID BURDEN THAT ARE ASSOCIATED WITH CEREBROSPINAL FLUID AD BIOMARKERS IN PEOPLE AT RISK FOR ALZHEIMER'S DISEASE: FINDINGS FROM THE WRAP STUDY

2014 ◽  
Vol 10 ◽  
pp. P502-P503
Author(s):  
Annie Marie Racine ◽  
Bradley T. Christian ◽  
Cynthia M. Carlsson ◽  
Henrik Zetterberg ◽  
Ozioma Okonkwo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cerebrospinal Fluid ◽  
Amyloid Burden

IC-P-007: PATTERNS OF [C-11]PIB AMYLOID BURDEN THAT ARE ASSOCIATED WITH CEREBROSPINAL FLUID AD BIOMARKERS IN PEOPLE AT RISK FOR ALZHEIMER'S DISEASE: FINDINGS FROM THE WRAP STUDY

2014 ◽  
Vol 10 ◽  
pp. P10-P10
Author(s):  
Annie Marie Racine ◽  
Brad T. Christian ◽  
Cynthia M. Carlsson ◽  
Henrik Zetterberg ◽  
Ozioma Okonkwo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cerebrospinal Fluid ◽  
Amyloid Burden

scholarly journals Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults

2011 ◽  
Vol 31 (18) ◽  
pp. 6764-6770 ◽  
Author(s):  
M. N. Braskie ◽  
N. Jahanshad ◽  
J. L. Stein ◽  
M. Barysheva ◽  
K. L. McMahon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Young Adults ◽  
White Matter ◽  
Disease Risk ◽  
Risk Variant ◽  
White Matter Microstructure
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