Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer’s Disease-Like Pathologies in AβPPswe/PS1ΔE9 Mice

2016 ◽  
Vol 50 (3) ◽  
pp. 669-685 ◽  
Author(s):  
Hongyan Qiu ◽  
Rujia Zhong ◽  
Hui Liu ◽  
Feng Zhang ◽  
Song Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sleep Deprivation ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep

829 Chronic sleep deprivation in a 75-year-old female leading to micro-sleeps with atonia causing increased falls

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A323-A323
Author(s):  
Neeley Remmers ◽  
Michael Anderson ◽  
John Nelson
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Sleep Onset ◽  
Exercise Intolerance ◽  
Unique Case ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
History Of ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep

Abstract Introduction Each year, 3 million older people are treated in emergency departments for fall-related injuries. These falls can lead to serious injuries and expensive health care costs. Some have looked into the relationship between chronic sleep disturbances and falls linking chronic sleep deprivation or excessive sleep to falling. Here, we present a unique case of chronic sleep deprivation causing sleep attacks or micro-sleeps with atonia causing falls. Report of case(s) We present a 75-year-old F with a history of increased daily falls up to 4x per day that began 3 years ago. She denies any triggering events, auras, frequent tripping, loss of balance or weakness. Reportedly, she will be walking along then suddenly falls. She is aware that she is falling yet feels as though she cannot prevent/stop the fall or break her fall. No one has witnessed her fall, but is frequently found lying on the floor. She has never sustained a serious injury as a result of her falls. She has an 8 year history of restless legs syndrome treated with ropinirole and a 10 year history of obstructive sleep apnea (OSA) treated with CPAP. Her general bedtime is 2200 and wake-time is 0400 with an average 3–4 hrs of quality sleep per night for many years. She endorses severe daytime hypersomnolence and chronic hypoxemia on 3L home oxygen. We hypothesized her falls were secondary to sleep attacks or micro-sleeps where she enters REM sleep and develops atonia. Nocturnal sleep study followed by MSLT showed severe OSA with severe, persistent daytime sleeping with REM sleep and atonia. She had a mean sleep latency of 2 minutes with 1 sleep-onset REM period. We started NIPPV with supplemental oxygen treatment, and within 4 months her daytime hypersomnolence resolved, exercise intolerance improved, saturations improved to 89–90% on room air, and has <1 fall per day. Conclusion Here, we presented a unique case of a 75 yo F with recurrent falls secondary to chronic sleep deprivation causing micro-sleeps involving REM sleep and atonia. She was treated with NIPPV which improved her oxygenation and reduced her number of falls to <1 per day. Support (if any):

scholarly journals Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor—Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization

2019 ◽  
Vol 20 (13) ◽  
pp. 3273 ◽  
Author(s):  
Zdenka Kristofikova ◽  
Jana Sirova ◽  
Jan Klaschka ◽  
Saak V. Ovsepian
Keyword(s):  
Nitric Oxide ◽  
Nmda Receptor ◽  
Sleep Deprivation ◽  
Nmda Receptor Subunits ◽  
Aspartate Receptor ◽  
Age Dependent ◽  
Chronic Sleep Deprivation ◽  
Nos Isoforms ◽  
The Impact ◽  
Chronic Sleep

Aging and chronic sleep deprivation (SD) are well-recognized risk factors for Alzheimer’s disease (AD), with N-methyl-D-aspartate receptor (NMDA) and downstream nitric oxide (NO) signalling implicated in the process. Herein, we investigate the impact of the age- and acute or chronic SD-dependent changes on the expression of NMDA receptor subunits (NR1, NR2A, and NR2B) and on the activities of NO synthase (NOS) isoforms in the cortex of Wistar rats, with reference to cerebral lateralization. In young adult controls, somewhat lateralized seasonal variations in neuronal and endothelial NOS have been observed. In aged rats, overall decreases in NR1, NR2A, and NR2B expression and reduction in neuronal and endothelial NOS activities were found. The age-dependent changes in NR1 and NR2B significantly correlated with neuronal NOS in both hemispheres. Changes evoked by chronic SD (dysfunction of endothelial NOS and the increasing role of NR2A) differed from those evoked by acute SD (increase in inducible NOS in the right side). Collectively, these results demonstrate age-dependent regulation of the level of NMDA receptor subunits and downstream NOS isoforms throughout the rat brain, which could be partly mimicked by SD. As described herein, age and SD alterations in the prevalence of NMDA receptors and NOS could contribute towards cognitive decline in the elderly, as well as in the pathobiology of AD and the neurodegenerative process.

The neuroprotective effect of osthole against chronic sleep deprivation (CSD)-induced memory impairment in rats

Life Sciences ◽  
2020 ◽  
Vol 263 ◽  
pp. 118524
Author(s):  
Hanqing Tang ◽  
Keming Li ◽  
Xibin Dou ◽  
Yufeng Zhao ◽  
Chunchuan Huang ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Memory Impairment ◽  
Neuroprotective Effect ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep

Effects of acute and chronic sleep deprivation on eating behaviour

2020 ◽  
Vol 24 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Caterina Lombardo ◽  
Andrea Ballesio ◽  
Giordana Gasparrini ◽  
Silvia Cerolini
Keyword(s):  
Sleep Deprivation ◽  
Eating Behaviour ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep

scholarly journals Daily Acclimation Handling Does Not Affect Hippocampal Long-Term Potentiation or Cause Chronic Sleep Deprivation in Mice

SLEEP ◽  
2013 ◽  
Vol 36 (4) ◽  
pp. 601-607 ◽  
Author(s):  
Christopher G. Vecsey ◽  
Mathieu E. J. Wimmer ◽  
Robbert Havekes ◽  
Alan J. Park ◽  
Isaac J. Perron ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep

scholarly journals Pumilio Regulates Sleep Homeostasis in Response to Chronic Sleep Deprivation in Drosophila melanogaster

2020 ◽  
Vol 14 ◽  
Author(s):  
Luis A. De Jesús-Olmo ◽  
Norma Rodríguez ◽  
Marcelo Francia ◽  
Jonathan Alemán-Rios ◽  
Carlos J. Pacheco-Agosto ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Sleep Deprivation ◽  
Sleep Homeostasis ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep
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