scholarly journals Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer’s Disease

2016 ◽  
Vol 53 (3) ◽  
pp. 921-932 ◽  
Author(s):  
Vincent Chouraki ◽  
Christiane Reitz ◽  
Fleur Maury ◽  
Joshua C. Bis ◽  
Celine Bellenguez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Prediction ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

scholarly journals P4-574: FUNCTIONAL CONNECTIVITY HYPOSYNCHRONIZATION IN A GROUP OF COGNITIVELY INTACT OLDER FEMALES: THE USE OF A GENETIC RISK SCORE FOR ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1539-P1540
Author(s):  
Inmaculada Concepción Rodríguez Rojo ◽  
Pablo Cuesta ◽  
Ernesto Pereda ◽  
Ricardo Bruña Fernández ◽  
Ana Barabash ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Cognitively Intact

scholarly journals An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults

eNeuro ◽  
2016 ◽  
Vol 3 (3) ◽  
pp. ENEURO.0098-16.2016 ◽  
Author(s):  
Theresa M. Harrison ◽  
Zanjbeel Mahmood ◽  
Edward P. Lau ◽  
Alexandra M. Karacozoff ◽  
Alison C. Burggren ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Healthy Older Adults ◽  
Hippocampal Complex

scholarly journals Using a genetic risk score to estimate the earliest age of Alzheimer’s disease-related physiologic change in Body Mass Index

2019 ◽  
Author(s):  
Willa D. Brenowitz ◽  
Scott C. Zimmerman ◽  
Teresa J. Filshtein ◽  
Kristine Yaffe ◽  
Stefan Walter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Weight Loss ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Genetic Ancestry ◽  
Uk Biobank

AbstractObjectivesWeight loss is common in the years before an Alzheimer’s disease (AD) diagnosis, likely due to changes in appetite and diet. The age at which this change in body mass index (BMI) emerges is unclear but may point to the earliest manifestations of AD, timing that may be important for identifying windows of intervention or risk reduction. We examined the association between AD genetic risk and cross-sectional BMI across adults in mid-to late-life as an innovative approach to determine the age at which BMI changes and may indicate preclinical AD.DesignObservational studySettingUK BiobankParticipants407,386 UK Biobank non-demented participants aged 39-70 with Caucasian genetic ancestry enrolled 2007-2010.Main Outcome MeasuresBMI (kg/m2) was constructed from height and weight measured during the initial visit. A genetic risk score for AD (AD-GRS) was calculated as a weighted sum of 23 genetic variants previously confirmed to be genome-wide significant predictors of AD (Z-scored). We evaluated whether the association of AD-GRS with BMI differed by age using linear regression with adjustment for sex and genetic ancestry, stratified by age grouping (40-60, 61+). We calculated the earliest age at which high AD-GRS predicted divergence in BMI compared to normal age-related BMI trends with linear and quadratic terms for age and interactions with AD-GRS.ResultsIn 39-49 year olds, AD-GRS was not significantly associated with lower BMI (0.00 kg/m2 per SD in AD-GRS; 95%CI: -0.03,0.03). In 50-59 year olds AD-GRS was associated with lower BMI (-0.03 kg/m2 per 1 SD in AD-GRS; 95%CI:-0.06,-0.01) and this association was stronger in 60-70 year olds (-0.09 kg/m2 per 1 SD in AD-GRS; 95%CI:-0.12,-0.07). Model-based BMI age-curves for people with high versus low AD-GRS scores began to diverge after age 47.InterpretationGenetic factors that increase AD risk begin to predict lower BMI in adults by age 50, with greater effect later in older ages. Weight loss may manifest as an early pathophysiologic change associated with AD.

[P1-139]: PATHWAY-SPECIFIC GENETIC RISK SCORE ASSOCIATED WITH ALZHEIMER's DISEASE AND WHITE MATTER LESIONS IN COGNITIVELY NORMAL SUBJECTS

2017 ◽  
Vol 13 (7S_Part_6) ◽  
pp. P295-P296
Author(s):  
Shahzad Ahmad ◽  
Christian Bannister ◽  
Sven J. van der Lee ◽  
Dina Vojinovic ◽  
Hieab H.H. Adams ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
White Matter Lesions ◽  
Normal Subjects ◽  
Cognitively Normal ◽  
Cognitively Normal Subjects
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